View: session overviewtalk overview
| 10:30 | Cardiac dynamics and arrhythmic risk in aged and failing hearts: insights from experimental and computational research SPEAKER: Esther Pueyo |
| 11:00 | Combining tissue heterogeneity and anisotropy in a fractional model of cardiac electrophysiology SPEAKER: Nicole Cusimano |
| 11:15 | A patient-specific fluid-structure interaction analysis of TAVI procedure SPEAKER: Giulia Luraghi |
| 11:30 | Effect of fibrosis on BSPM of patients with focal atrial tachycardia SPEAKER: Ignacio García-Fernández |
| 11:45 | Validation of a reduced order model for prediction of FFR, using in vivo data, 3D INS and UQ & SA SPEAKER: Fredrik Eikeland Fossan |
| 12:00 | Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability under sympathetic provocation SPEAKER: David Adolfo Sampedro-Puente |
| 12:15 | Computational pre-surgical planning of cardiovascular patch reconstruction – pre-operative structural and hemodynamic performance in selected clinical cases SPEAKER: Kerem Pekkan |
| 10:30 | Towards functional pre-planning in orthopaedic surgery SPEAKER: Nico Verdonschot |
| 11:00 | Stability of anterograde intramedullary nails in distal femoral fractures SPEAKER: Sergio Puértolas |
| 11:15 | Apex Vertebra Transpositions in the 3D Optical Diagnosis of 372 Patients with Adolescent Idiopathic Scoliosis SPEAKER: Sasa Cukovic |
| 11:30 | A phantom-less calibration technique for use in femur strength prediction SPEAKER: Carla Winsor |
| 11:45 | Design of an electro-stimulating system for a defective minipig mandible SPEAKER: Hendrikje Raben |
| 12:00 | Integration of Cortical Thickness data in a Statistical Shape Model of the Scapula SPEAKER: Jonathan Pitocchi |
| 12:15 | Development of a physiologically relevant structural model of the pelvic construct to simulate fracture SPEAKER: Andrew Phillips |
| 10:30 | FE modelling of alveolar mechanics based on the Weaire-Phelan unit cell SPEAKER: Gabriel Beltrán Lostal |
| 10:45 | Modelling the cerebral diffusive spread of pathology in Parkinson’s disease SPEAKER: Ronan Mt Fleming |
| 11:00 | An Averaged Geometry of the Human Nasal Cavity SPEAKER: Jan Bruening |
| 11:15 | o2S2PARC – The Simulation Core of the NIH SPARC Initiative SPEAKER: Esra Neufeld |
| 11:30 | How Ionic Imbalances Alter Axonal Conduction. A Computational Study. SPEAKER: Alberto Montolío Marco |
| 11:45 | An in silico HBV model predicts viral response to the oral non-steroidal carboxylic acid FXR agonist EYP001a SPEAKER: Evgueni Jacob |
| 12:00 | A preliminary in silico model of the thrombectomy procedure SPEAKER: Jose Felix Rodriguez Matas |
| 12:15 | Customized design of colonic stents based on a parametric model SPEAKER: Sergio Puértolas |
| 10:30 | A microstructurally-based material model for the description of skeletal muscle tissue SPEAKER: Christian Bleiler |
| 10:45 | Simulating Electromyography (EMG) Signals by Using a Generalized Bidomain Approach SPEAKER: Thomas Klotz |
| 11:00 | Semantics-based model discovery for renal transport SPEAKER: David Nickerson |
| 11:15 | Whole Brain Simulations in Mouse Elucidate Mechanisms of Local Cerebral Blood Flow Control SPEAKER: Andreas Linninger |
| 11:30 | Intracranial Aneurysms: A Patient-Specific Fluid-Solid-Growth (FSG) Framework with Modelling of Endothelial Response SPEAKER: Yuqian Mei |
| 11:45 | BioGears: An In-Silico Whole-Body Framework to Simulate Kinetics and Dynamics of Pharmaceuticals and Associated Reversal Agents SPEAKER: Austin Baird |
| 12:00 | Multiscale model of transport and uncoiling of ultralarge proteins in cellular blood flows SPEAKER: Alfons Hoekstra |
| 10:30 | Organs Hybrid Twin: towards a new paradigm in computational surgery SPEAKER: Elias Cueto |
| 11:00 | On the evaluation of hip fracture risk using advanced machine learning techniques SPEAKER: Enrique Nadal |
| 11:15 | Deformable Augmented Reality via Model Order Reduction Methods SPEAKER: Alberto Badias |
| 11:30 | A Model Execution Environment for Valvular Heart Condition Simulations SPEAKER: Piotr Nowakowski |
| 11:45 | Modelling and control of an adaptive biohybrid device for modulation of inflammation SPEAKER: Judy Day |
10:30 – 10:40: “Welcome and Introduction to ANSYS”; Thierry Marchal, Global Industry Director Healthcare, ANSYS
10:40 – 11:05: “Computational-based MRI Thermal Injury Risk Assessment for Patients implanted with Passive Spinal Devices”; Payman Afshari, Sr. Principal Engineer at DePuy Synthes Spine, Johnson and Johnson
11:05 – 11:30: “Getting to Know Your Digital Twin”; Marc Horner, Technical Lead Healthcare North America, ANSYS
11:30 – 11:55: "Why In Silico Healthcare is important for Medtronic?"; Mark Palmer, Senior Principal Scientist, Science Technology & New Therapies, Medtronic
11:55 – 12:20: “An on-line platform to facilitate in silico clinical trials while complying to FDA guidances”; Luca Emil, CEO In Silico Trials Technologies
12:20 – 12:30: Wrap up & Discussion, Thierry Marchal
| 14:00 | InSilc: In Silico Trials for drug-eluting bioabsorbable vascular scaffold (BVS) development and evaluation SPEAKER: Ted Vaughan |
| 14:15 | A platform for patient-specific vascular medicine: a case study of a chronic type-B aortic dissection SPEAKER: Mirko Bonfanti |
| 14:30 | In silico stent deployment in the coronary artery with plaque progression SPEAKER: Velibor Isailovic |
| 14:45 | Embedded Computational Fluid Dynamics to study cardiovascular pathologies: Aortic Dissection. SPEAKER: Rubén Zorrilla |
| 15:00 | An anatomical surrogate of wall compliance in the child heart SPEAKER: Maciej Marciniak |
| 15:15 | A rule based method for assigning fiber information to heart complex structures SPEAKER: Ruben Doste |
| 15:30 | A 4D Flow MRI-based modelling approach to assess left ventricular function during rest and stress conditions SPEAKER: Belen Casas |
| 15:45 | Automatic segmentation of the atrial region using a competitive deformable model approach SPEAKER: João Manuel R. S. Tavares |
| 14:00 | Effect of high-impact exercise on trabecular bone adaptation in postmenopausal women SPEAKER: Juan Du |
| 14:15 | Patient-Specific Principal Component Analysis Stratifies Multiple Organ Dysfunction Outcomes based on Type 17 Immune Responses in Blunt Trauma Patients in the First 24 Hours Following Injury SPEAKER: Lukas Schimunek |
| 14:30 | Thoracic Deformation in Nearside Oblique Sled Impacts SPEAKER: Ana I Lorente |
| 14:45 | Development and Evaluation of a Subject-Specific Brain Injury Model SPEAKER: J. Sebastian Giudice |
| 15:00 | Effect of Bone Micromorphology on Multiple Crack Propagation: Finite-element Analysis SPEAKER: Vadim Silberschmidt |
| 15:15 | DXA-based 3D patient-specific femur model simulations for hip fracture prediction SPEAKER: Carlos Ruiz Wills |
| 15:30 | Influence of the head size in the injury metrics for oblique impacts SPEAKER: Ana Piqueras |
| 15:45 | Using digital image correlation to validate meniscus tear patterns predicted by continuum damage models SPEAKER: Trevor Lujan |
| 14:00 | Image-based in vitro analysis and computational modelling to characterise the mechanical environment of bone cells during osteoporosis SPEAKER: Laoise Mcnamara |
| 14:30 | A model for endothelial cell migration under flow conditions SPEAKER: Pavel Zun |
| 14:45 | Calibrating a stochastic model of cell migration using image-based in vitro analysis and Bayesian optimization. SPEAKER: Francisco Merino-Casallo |
| 15:00 | Cerebral aneurysm tissue investigation: experiment and simulations SPEAKER: Daniil Parshin |
| 15:15 | IMAGO: an online platform for microscopy image analysis in in-vitro experiments SPEAKER: Carlos Borau |
| 15:30 | On the context of use of directly validated spinal functional units FE models SPEAKER: Marlene Mengoni |
| 15:45 | A novel 3D printed bioinspired cardiac pneumatic pump: from design to numerical and experimental study SPEAKER: Emanuele Vignali |
| 14:00 | In silico characterisation of the spatiotemporal evolution of stem cell niches during neotissue growth in 3D scaffolds during perfusion bioreactor culture SPEAKER: Liesbet Geris |
| 14:30 | Finite element analysis of individual cell migration under conditions of mechanical confinement SPEAKER: Silvia Hervás |
| 14:45 | Influence of the mechanical properties of cell nucleus on overall deformation of the cell: a computational study SPEAKER: Francisco Serrano Alcalde |
| 15:00 | Cell resolved simulations of saccular aneurysms: effects of pulsatility and aspect ratio SPEAKER: Benjmain Czaja |
| 15:15 | A multiphysic simulation of mechanotransduction effect through stretch operated channels in the uterine muscle. SPEAKER: Catherine Marque |
| 15:30 | Modelling high shear-rate platelet aggregation on cellular level SPEAKER: Britt van Rooij |
| 15:45 | NEUROMAN: Implementing Neuro-Functionalized Computational Human Body Models SPEAKER: Bryn Lloyd |
| 14:00 | Development of Computational Patient Avatars by Manifold Learning SPEAKER: Elías Cueto |
| 14:15 | The use of neuronal networks to help in pathologies diagnosis SPEAKER: Alejandro Martín Gallego |
| 14:30 | Full-blown 3D blood flow simulation in approach of effective compressibility as a model of vessel elasticity SPEAKER: Andrey Svitenkov |
| 14:45 | Reduced order modelling of electroporation in biological tissues for pulse delivery optimization SPEAKER: Nathan Lauzeral |
| 15:00 | Instabilities in Time Series from Intensive Care Units: A Sepsis Case Study SPEAKER: Satya Swarup Samal |
Technology transfer and access: challenges and opportunities
In the last decades, universities and research centers have been applying modeling and simulation (M&S) to problems involving health and medicine, coining the new expression in silico clinical trials, but its use is still limited to a restricted pool of expert adopters.
Making M&S available to a broad spectrum of potential users (medical device and pharmaceutical companies, hospitals, healthcare institutions) would require an easy and controlled access to models and computational resources in a secure and compliant environment while protecting the intellectual property of the models’ creators.
Meanwhile, the European and USA regulatory agencies are starting to recognize the use of M&S in the research and technological development and to provide evidence in the approval process for new medical products. A joint effort from academia, industry and regulatory bodies is then required to reach a rapid adoption of a harmonized approach.
In this session, we will talk about potentials, limitations, challenges, and opportunities that the community has to deal with to leverage the significant value of M&S solutions which are being developed but are not fully exploited, in order to reach a broad adoption and democratization of simulations in healthcare.
Session topics:
- 14:00 – 14:15 Is there a "Valley of Death" for in silico medicine technologies? - Marco Viceconti, Executive Director at Insigneo Institute for in silico Medicine
- 14:15 – 14:30 In silico modelling: From lab to the end-users - Javier Saiz, Professor at Universidad Politécnica de Valencia
- 14:30 – 14:45 Learning from other industries: exploiting world class research to accelerate industrial innovations - Thierry Marchal, ANSYS Global Industry director
- 14:45 – 15:00 One model for all and all efforts as one! - Nico Verdonschot, Scientific Director of Technical Medical Center at University of Twente
- 15:00 – 15:15 Commercializing Computational Models of Inflammation: Past, Present, and Future - Yoram Vodovotz, Director at Center for Inflammation and Regenerative Modeling, University of Pittsburgh
- 15:15 – 15:30 Technology transfer and technology access. How InSilicoTrials is working with researchers and industry – Luca Emili, CEO at InSilicoTrials Technologies
- 15:30 – 16:00 Round Table, moderator: Luca Emili, CEO at InSilicoTrials Technologies
Target: Industry specialists (product developers, regulatory affair, clinical trialists, etc.)
Tentative programme
16:30 – 16:45 The emerging regulatory landscape for in silico methods – Tina Morrison, FDA
16:45 – 17:30 Tools and services for in silico clinical trials: Moderator: Thierry Marchal, Avicenna Alliance.
Ansys – Representative.
Materialise – Sjoerd Kolk.
InsilicoTrials – Luca Emili.
Quibim – Angel Alberich-Bayarri.
17:30 – 17:45 In silico Clinical Trials: A vision of the future: Marco Viceconti, Insigneo Institute
17:45 – 18:00 Examples of early applications: Mark Palmer, Medtronic
18:00 – 18:10 Scalability of Computational Medicine applications: Peter Coveney, CompBioMed CoE
18:10 – 18:45 Round table. Moderator: Thierry Marchal, Avicenna Alliance