VPH2018: VIRTUAL PHYSIOLOGICAL HUMAN 2018
PROGRAM FOR WEDNESDAY, SEPTEMBER 5TH
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08:30-09:00 Session 1: Opening Ceremony

The confirmed chairs for these sessions are:

-José Antonio Mayoral, Dean of the University of Zaragoza.

-Liesbet Geris, Director of VPH Institute.

-José Ángel Castellanos, Director of the EINA.

-Ignacio Garcés, Director of I3A.

-Pilar Alegría, Goverment of Aragón

09:00-10:00 Session 2: Plenary speaker I
09:00
Numerical models for the heart function

ABSTRACT. Mathematical models based on first principles allow the description of the blood motion in the human circulatory system, as well as the interaction between electrical, mechanical and fluid-dynamical processes occurring in the heart. This is a classical environment where multi-physics processes have to be addressed. Appropriate numerical strategies can be devised to allow for an effective description of the fluid in large and medium size arteries, the analysis of physiological and pathological conditions, and the simulation, control and shape optimization of assisted devices or surgical prostheses. This presentation will address some of these issues and a few representative applications of clinical interest.

10:00-10:30Coffee Break
10:30-12:30 Session 3A: Cardiovascular modeling: from simulation to clinical outcome organised by E-cardiology I
10:30
Phase maps based on the electrograms from basket catheters might generate false rotors
10:45
Tx, a new biomarker for in-silico early assessment of drug-induced proarrhythmic risk
SPEAKER: Jordi Cano
11:00
Left Atrium Patient-Specific Modelling from Electroanatomical Maps
11:15
Clinical MRI-based multiscale computational models of heart and torso to investigate the role of anatomy on ECG
SPEAKER: Ana Minchole
11:30
A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability
11:45
Automatic Atrial Fibrillation Initiation for the Evaluation of Proarrhythmic Risk at Tissue In-Silico Models
12:00
Arrhythmogenic mechanisms in silent acute myocardial ischemia
12:15
Neural networks to classify ischemic ECG signals: a computational study
10:30-12:30 Session 3B: Surgical Decision Support
Location: Room 0.01
10:30
Surgical Decision Support in Knee Surgery
11:00
Mathematical model of fluid status after intravenous fluid infusion
11:15
Automation and validation of a musculoskeletal model setup for predicting TKA functional outcome
11:30
Towards Real-Time Transaortic Pressure Gradient Computation
11:45
Computerized Clinical Decision Support System for Childbirth Management: Preliminary Considerations
12:00
Surgical planning in relation to atrioventricular valve regurgitation in single-ventricle physiology: the dilemma of valve repair
SPEAKER: Sanjay Pant
10:30-12:30 Session 3C: Clinical Applications and Personalized Medicine: Models in Oncology
Location: Room 0.02
10:30
In Silico Oncology: Building and validating hypermodels and Oncosimulators as clinical decision support systems in the framework of the EU-US CHIC project
11:00
Assessing Radiotherapy Effectiveness in Prostate Cancer: model validation on the EUREKA2 cohorts
SPEAKER: Ilaria Stura
11:15
In Silico Oncology: A vascular tumour growth based Oncosimulator for reproducing the clinical time-course of breast cancer patients undergoing bevacizumab mono-therapy
11:30
Bridging the gap between basic science and clinical oncology by IT infrastructures for models to support clinical decision support
SPEAKER: Norbert Graf
11:45
Tackling acquired resistance mechanisms in malignant melanoma.
SPEAKER: Jens Rauch
12:00
In Silico Evaluation of Inhibitory Potential with Rapid and Reliable Binding Affinity Predictions
SPEAKER: Peter Coveney
12:15
Progress in cell-based, quasi-lattice-free simulations of vascularized solid tumours
10:30-12:30 Session 3D: Multiscale modeling I
Location: Room 0.03
10:30
Multiscale VPH models: better predictive accuracy or increased explanatory power? Reflection on the hip fractures problem
11:00
Physiome: encouraging reproducibly FAIR computational modelling
11:15
The Role of Multiscale Time in Multiscale Systems Biology
SPEAKER: Azam Khan
11:30
Efficacy of hip fracture risk reduction using multifactorial interventions combining environmental hazard management and balance training
11:45
Forward simulations of three-dimensional, continuum-mechanical musculoskeletal system models
12:00
In-Silico Modelling of Oesophageal Tissue for Treatment of Long Gap Oesophageal Atresia
SPEAKER: Hamna Afaq
12:15
Multiphysic Approach for Bicomponent Tissue Engineered Bone Grafts
10:30-12:30 Session 3E: Inverse problems for model personalization I
Location: Room 0.04
10:30
The Effect of Kinematic and Dynamic Redundancy on the Assessment of Joint Reaction Loads
10:45
Personalization of one-dimensional blood flow models via a reduced-order unscented Kalman filter in the frequency domain
11:00
Overcoming aliasing in velocity-encoded MRI for blood flow computations
11:15
Modelling of impulsive source in a prestressed soft tissue
11:30
Clinical Personalization of Models of Left Ventricular Electromechanics
11:45
Modeling and inverse problems in tumor growth
SPEAKER: Olivier Saut
12:00
Combined Machine Learning and Textural Image Analysis of endometrial Ultrasound images for prediction of egg implantation rate and ongoing pregnancy in infertile patients
SPEAKER: Belén Fos
12:15
Mathematical modelling acute myocardial infarction using in vivo magnetic resonance imaging
SPEAKER: Hao Gao
12:30-14:00Lunch Break
14:00-15:30 Session 5A: Cardiovascular modeling: from simulation to clinical outcome organised by E-cardiology II
14:00
Image-derived, population specific analysis of the mitral valve apparatus: towards a realistic setting for device in-silico testing
14:15
Uncertainty in Non-Invasive, Numerical Assessment of Pressure Drop across a Coarctation of the Aorta
14:30
Inaccuracies of clinical pressure gradient measurements: Quantification of pressure recovery in aortic valve conditions
14:45
Predictive Modeling of Isolated Aortic Valve Replacement
15:00
A Clinical Pathway for Patient-Specific Simulation of Left Ventricle Hemodynamics Based on Echocardiography
SPEAKER: Johan Hoffman
14:00-15:30 Session 5B: Orthopaedics and craneofacial I
Location: Room 0.01
14:00
Surrogate-based optimization of acetabular implant design through minimization of stress shielding
14:15
Twente Spine Model: A Study of the Intervertebral Disc Forces in Flexion
14:30
Patient-specific musculoskeletal models to characterise the response to disease activity in patients with Juvenile Idiopathic Arthritis
14:45
Estimation of Subject-specific Knee Ligament Properties
15:00
A Collaborative Strategy to Establish Reproducibility in Simulation-Based Prediction of Natural Knee Mechanics
15:15
Investigating bone health in trans-femoral amputees
14:00-15:30 Session 5C: Agent-based models
Location: Room 0.02
14:00
Multiscale Biophysical Modeling of Receptor Activation, Signaling and Trafficking in Cancer
14:15
Lattice-gas cellular automaton models for collective cell migration
14:30
Insights of avascular tumour growth by means of a biphasic porous elastic model
14:45
Statistical Shape Analysis of the Right Ventricular Outflow Tract in Patients with Tetralogy of Fallot
15:00
3D Agent Based Modelling of Intervertebral Disc Nucleus Pulposus cells to simulate the effects of disc tissue property alterations
14:00-15:30 Session 5D: Multiscale modeling II
Location: Room 0.03
14:00
Computational modelling of the effect of growth factors on human mesenchymal stem cell proliferation in 3D porous scaffolds
14:15
Insights into mechanisms of resistance to renal denervation using topological analysis of simulation
14:30
Computational Modelling of the Role of GLUT2 in Glucose Uptake by Intestinal Epithelial Cells
SPEAKER: Nima Afshar
14:45
OpenCOR: a modelling environment for reproducible science
SPEAKER: Alan Garny
15:00
Computational Model of Wound Healing Angiogenesis: a Preliminary Study
SPEAKER: Ana Guerra
14:00-15:30 Session 5E: Inverse problems for model personalization II
Location: Room 0.04
14:00
Effective estimation for biomedical models
14:30
Numerical design of composite biomarkers
14:45
Validation of a sequential data assimilation method applied to cardiac electrophysiology
15:00
Reduced Order Modeling for Uncertainty Quantification of the cardiac function
15:30-16:00 Session 6A: Flash Presentation I
15:30
Patient Profiles and Clinical Event Simulations in a Left Heart Simulator
15:34
Steps, energy expenditure and heart rate agreement of five activity trackers
15:38
Soft Tissue Growth and Remodelling Framework: Application in Myocardial Infarction
15:42
Evaluation of SPH method for cardiac flow simulations
15:46
In vivo evaluation of noradrenaline effects using a heart model
15:50
Non-invasive cardiac stress tests: a 0D modelling approach
SPEAKER: Kay Brosien
15:54
Modular open-source workflow for in silico studies of atrial electrophysiology
15:30-16:00 Session 6B: Flash Presentation II
Location: Room 0.01
15:30
Simulation approach for the prediction of hemodynamic after virtual mitral valve repair interventions
15:34
Patient specific 0D model of the systemic circulation to simulate the effects of valve stenosis and regurgitation
15:38
Fluid parametric model of the blood flow in the ascending aorta
SPEAKER: Myriam Cilla
15:42
Numerical study of thrombus formation processes in branched vascular networks
15:46
The impact of genomics in the development of a diagnostic model for stable coronary artery disease.
15:50
On modelling patient-specific carotid atherosclerotic plaque formation
15:54
An integrated image-based framework for the mechanical characterization of patient-specific blood vessels
15:30-16:00 Session 6C: Flash Presentation III
Location: Room 0.02
15:30
Atrial Flutter Re-entrant Circuit Identification based on Body Surface Phase Mapping
15:34
Development of a Finite Element Model to assess tumour tissue evolution
SPEAKER: Elena Ibarz
15:38
Outlet resistance estimation for 1D pulse wave propagation modelling in the cerebral arteries
SPEAKER: Juliana Franz
15:42
Agent-based modelling of contraction of burns
SPEAKER: Qiyao Peng
15:46
The Back-UP Project: Towards predictive diagnosis and personalised medicine for NLBP underpinned by the VPH technologies and vision
15:50
Security Tools for Modern Computational Medicine
SPEAKER: Jan Meizner
15:54
A Rubric for Evaluating the Credible Practice of Computational Modeling and Simulation in Healthcare
15:30-16:00 Session 6D: Flash Presentation IV
Location: Room 0.03
15:30
Application of a genetic algorithm to check the variation of the biomechanical properties of asymptomatic and incontinent women
15:34
Morphing detailed human body models to represent weight change
SPEAKER: Yoann Lafon
15:38
Electromagnetic stimulation chambers for chondrocytes
15:42
Coupling of finite element and electro-chemical models of the uterine muscle
15:46
Numerical simulation of intraocular lens implantation in the lens capsule during the cataract surgery procedure
15:50
Global sensitivity analysis of HD-sEMG amplitude descriptors from a cylindrical multilayered muscle model
15:54
Three-dimensional (3D) Multiscale Model of the Contracting Ventricle
SPEAKER: A. Amar
15:30-16:00 Session 6E: Flash Presentation V
Location: Room 0.04
15:30
Virtual Assessment of the Primary Stability of Hip Prostheses
SPEAKER: Jeff Bischoff
15:34
Augmentation and Screw Assisted Internal Fixation (SAIF) in osteoporotic vertebrae: a finite element analysis of a new technique
15:38
Model-based design of 3D-printed calcium-phosphate based biomaterials for dental applications
15:42
An Agent-Based Model of the Bone Remodelling Process and its Disruption by Multiple Myeloma
15:46
Patient-specific frequency analysis for the preoperative evaluation of implant stability
15:50
Biomechanical Behaviour Of The Joint Sub/Astragalin, Skills with Supported Bodies, with a View to Designing a Prosthetic Replacement Prototype for Talus.
15:54
Optimizing material and design specifications of bioresorbable CMF plates using an in-silico model of a 4-point bending test
SPEAKER: Maria Hilvert
16:00-16:30Coffee Break
16:30-18:00 Session 7A: In silico Medicine in FP9

Liesbet Geris – VPHi Executive Director: “The VPH Institute: promoting in silico medicine research” and “the VPHi FP9 Position Paper”

Violeta Isabel Pérez Nueno - European Commission Officer: “Future priorities of in-silico medicine”

Tina Morrison (FDA): "FDA research priorities for in silico medicine"

 Q&A

16:30-18:00 Session 7B: ERC & MSCA session

ATTRACTIVE OPPORTUNITIES FOR YOUNG RESEARCHERS IN EUROPEAN PROJECTS (H2020)

This talk will show an overview of different opportunities for young researchers in the frame of European Projects (H2020).

In order to cover all the aspects involved in a proposal preparation, both the formal issues of the calls as well as success cases will be presented.

Fundamental elements regarding preparation of the proposal will be reviewed, with particular emphasis on the definition of the problem that wants to be solved, its significance and the selection of an innovative methodology to tackle it.

Based on previous experiences of H2020 applicants, tips will be provided on: the importance of identifying the best moment to present the proposal; the time you should reserve to not only write but more crucially to think about your idea; or the benefit of seeking for advice from colleagues with expertise in different disciplines, not necessarily close to yours.

Finally, the talk will go over the way you report your CV and your past achievements and how this can influence how others may or may not see you as the best possible researcher to carry out the project you are presenting.

16:30-17:15 Elena Portero – UNIZAR European Project Office & Francisco Gaspar – MSCA granted researcher: “MSC Actions Individual Fellowships: Formal Issues, Success case experience and Q&A”
17:15-18:00 Elena Portero – UNIZAR European Project Office & Esther Pueyo – ERC granted researcher: “ERC Starting Grants: Formal Issues, Success case experience and Q&A”

Location: Room 0.01
18:00-20:30 Session 8: VPH networking event (only registration for VPH members)

18:05 – 18:15: Lies Geris – VPHi Executive Director: “Introduction on the scope of the session”

18:15 – 18:25: Martina Contin – VPHi Manager ”VPHi as a project partner: community engagement and outreach”

18:25– 19:00: Juan Riese – Spanish NCP: “Presentation of the VPH related calls in last work program of H2020”

19:00: – 19:30: Q&A session on H2020 calls

19:30 – 20:30: Networking session – Drinks and small buffet

 

Location: Room 0.01
21:00-22:30Student's social night