Drug Resistance Mechanisms and Countermeasures

EasyChair Preprint 15040

Abstract

The rise of drug resistance poses a significant challenge to global healthcare, limiting the efficacy of treatments for infections, cancers, and other diseases. Drug resistance mechanisms in microorganisms, cancer cells, and other pathogens can arise from genetic mutations, efflux pumps, biofilm formation, and enzymatic degradation, leading to the failure of standard therapeutic approaches. This review explores the molecular pathways that contribute to resistance, such as alterations in drug targets, overexpression of drug efflux systems, and horizontal gene transfer. In response, several countermeasures have been developed, including novel drug formulations, combination therapies, and precision medicine approaches. Emerging technologies like CRISPR-Cas9 gene editing and nanoparticle-based drug delivery also offer promising avenues for overcoming resistance. A comprehensive understanding of these resistance mechanisms, coupled with innovative therapeutic strategies, is critical to combatting the growing threat of drug-resistant diseases.

Keyphrases: BET, Bromodomain, Epigenetics, cancer, computer-aided drug design, dual inhibitor, inhibitor, kinase

@booklet{EasyChair:15040,
  author    = {Favour Olaoye and Kaledio Potter and Axel Egon},
  title     = {Drug Resistance Mechanisms and Countermeasures},
  howpublished = {EasyChair Preprint 15040},
  year      = {EasyChair, 2024}}