Characterization and Release Profile of Mangosteen Extract from Chitosan-Alginate Microparticles in Tablet

EasyChair Preprint no. 3657

Abstract

Mangosteen pericarp extract has been reported to contain high amount of xanthones, which are secondary plant metabolites, which have high antioxidant activity and pharmacologic properties. In this research, xanthones that have poor oral bioavailability were encapsulated into chitosan alginate microparticles using ionic gelation method. The purpose of this study was to obtain a chitosan-alginate microparticle formulation with mangosteen peel extract containing mangostin which was used as an antioxidant supplement preparation and to obtain observations of the dissolution test and its hardness and hardness test. Mangosteen peel extract is obtained by maceration extraction method with ethanol solvent. The α- mangostin content in the extract was 90.04%. Mangosteen peel extract made microparticles using chitosan-alginate to protect α-mangostin which is sensitive to the environment. The α- mangostin microparticles obtained had an encapsulation efficiency of 99.925% and loading of 6.234%. The supplement formulation in tablet form by adding excipients such as diluent (mannitol and lactose), binder (Na CMC) and lubricant (magnesium stearate and talc) with two different variations. Dissolution test results show the release of mangostin occurs by burst release in synthetic digestive solutions

Keyphrases: Antioxidant supplements, Dissolution test, mangostin, micro-particles, α-mangostin

@Booklet{EasyChair:3657,
  author = {David Lazuardi and Kianti Kasya Kiresya and Kamarza Mulia and Elsa Krisanti},
  title = {Characterization and Release Profile of Mangosteen Extract from Chitosan-Alginate Microparticles in Tablet},
  howpublished = {EasyChair Preprint no. 3657},

  year = {EasyChair, 2020}}