Histological Evaluation of Different Processing Methods for Bovine-Derived Xenografts

EasyChair Preprint no. 12675

Abstract

This study aimed to compare the histological characteristics of bovine-derived xenografts processed using different methods for potential use in bone regeneration procedures. Bovine bone xenografts were subjected to various processing techniques, including freeze-drying, deantigenation, demineralization, and decellularization. Histological evaluation was performed to assess bone architecture, cellularity, vascularization, and the presence of residual material.

Results revealed distinct histological features associated with each processing method. Freeze-drying resulted in well-preserved bone architecture and minimal disruption of the extracellular matrix. Deantigenation techniques demonstrated reduced immunogenicity with minimal residual antigens. Demineralization methods effectively removed mineral content, promoting enhanced osteoconductivity. Decellularization processes exhibited decreased cellular content, reducing the risk

 of immune rejection.

Overall, histological evaluation provided valuable insights into the effects of different processing methods on bovine-derived xenografts. These findings contribute to our understanding of the optimal processing techniques for xenograft materials in bone regeneration applications. Further research is warranted to correlate histological findings with clinical outcomes and establish guidelines for the selection of processing methods based on specific therapeutic objectives.

Keyphrases: Cellular Mechanisms, osteoinduction, Xenograft Materials

@Booklet{EasyChair:12675,
  author = {Emmanuel Idowu and Axel Egon and Lucas Doris},
  title = {Histological Evaluation of Different Processing Methods for Bovine-Derived Xenografts},
  howpublished = {EasyChair Preprint no. 12675},

  year = {EasyChair, 2024}}