Areas of Effectiveness of Defibrillating Pulse in the Energy/Phase Diagram for the Fibrillation Cycle on the Cardiomyocyte Model

EasyChair Preprint no. 61

Abstract

In the BeatBox simulation environment on the human heart ventricle myocyte model ten Tusscher-Panfilov 2006 the efficiency areas of the depolarizing defibrillation pulse in the energy/phase diagram for the fibrillation cycle are investigated. At any energy levels, the depolarizing pulse does not provide a long-term extension of refractoriness of all heart cardiomyocytes in different phases of the excitation wave cycle, but at a certain energy level, refractoriness is long-term extended in 90% of the cardiomyocytes in different phases of the fibrillation wave cycle. At high energy levels, the action of the depolarizing pulse leads to a one-time extension of the refractory period of cardiomyocytes to values exceeding the duration of the fibrillation wave period. Presumably long-term extension of refractoriness of cardiomiocites at low energy of depolarising pulse and one-time extension of refractoriness of all cardiomiocites at high energy of depolarising pulse are the mechanisms of defibrillation.

Keyphrases: BeatBox simulation environment, defibrillation, depolarizing pulse, extension of refractoriness, fibrillation wave cycle, human heart ventricle myocyte model, Refractory period, transmembrane potential

@Booklet{EasyChair:61,
  author = {Boris Gorbunov and Vyacheslav Vostrikov and Igor Nesterenko and Dmitry Telyshev},
  title = {Areas of Effectiveness of Defibrillating Pulse in the Energy/Phase Diagram for the Fibrillation Cycle on the Cardiomyocyte Model},
  howpublished = {EasyChair Preprint no. 61},
  doi = {10.29007/n83c},
  year = {EasyChair, 2018}}