The need for sustainable development of Ukrainian regions is due to the global threat of environmental degradation, the unstable situation in the world economy, low socio-economic indicators of the country, and weak innovation activity. An important factor that influences the economic development of regions is the ecological state of the environment. It plays one of the most important roles in the conducting of economic activities that require the use of natural resources. According to the results of the investigation, four clusters were formed. Cluster analysis made it possible to conduct a general assessment of the state of the regions of Ukraine, to form groups by similarity, and to draw sound conclusions about the existence of similarities in the economy. The formation of clusters and the development of sustainable development policies for individual clusters, which should have significant differences, taking into account their specifics, will contribute to the more effective achievement of sustainable development goals.