Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction.

Title:Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction.

Authors:Toni Mancini, Federico Mari, Annalisa Massini, Igor Melatti, Ivano Salvo, Stefano Sinisi, Enrico Tronci, Rainald Ehrig, Susanna Röblitz and Brigitte Leeners

Conference:RCRA-18

Tags:assisted reproduction, downregulation treatment, drug administration, human patient, hybrid system simulators, menstrual cycle, multi arm isct, non linear differential equation, optimal personalised treatment, personalised treatment, pharmacological treatment, precision medicine, search, silico clinical trial, virtual phenotype and virtual physiological human

Abstract:

In Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine.

In this paper we present a case study aiming at quantifying, by means of a multi-arm ISCT supervised by intelligent search, the potential impact of precision medicine approaches on a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction.