The Epoch of Reionization and Cosmic Dawn mark the emergence of the first luminous structures and remain among the least constrained phases of cosmic history. This talk explores the prospects for reconstructing the evolution of the early Universe through the joint interpretation of complementary observational probes. We will emphasize the synergy between cosmic microwave background measurements, quasar absorption spectra, the rapidly expanding census of high-redshift galaxies from JWST, and forthcoming observations of the redshifted 21 cm signal. A central theme is the requirement for self-consistent modelling of galaxy formation and the intergalactic medium in order to robustly connect theory with these diverse datasets. We will further discuss the role of advanced statistical and inference frameworks, including machine-learning–based approaches, in mitigating parameter degeneracies and maximizing the information content of multi-probe analyses. Finally, we will highlight how this combined observational program enables stringent constraints on reionization-era astrophysics while providing novel tests of the concordance cosmological model and potential signatures of new physics at high redshift.