This paper presents a work in progress on the application of Blueprint Personas as a foundational tool for advancing the digital transformation of health and care services in an aging society. The paper present how artificial intelligence (AI) and intelligent agents can support patients, caregivers, and healthcare professionals through customized, patient-centered care. By synthesizing detailed patient profiles, including medical, social, and personal factors, the aim is to enhance the interaction between healthcare technologies and users. Additionally,the work introduces the use of ontologies to structure knowledge in e-health systems, with a particular emphasis on integrating a Reference Ontology of Trust to ensure the reliability and transparency of AI-driven care solutions.This ongoing research aims to contribute to a more empathetic and effective digital health ecosystem.hor mayuse in the preparation of the documentation of their work.