Occupational hazards are important for health, safety and quality of life among elderly workers, especially, informal sector. Objectives: This study aimed to survey occupational hazards among the elderly informal workers in Nakhon Nayok province, Thailand. Methods: A cross-sectional survey using questionnaire was completed among 380 elderly workers. A detailed questionnaire was used to collect information on occupational hazards the occurrence of occupation-related illnesses. Data analysis was performed and presented using descriptive statistics. Results: The results revealed that 60.3% were women with the average age of 70.9 years (SD=7.3); 66.3 % had completed an elementary education. The majority of informal occupation was employee with 65.8%, followed by agricultural sector (32.6%). The most significant occupational health hazard was dust exposure (82.6%). Physical hazards were heat exposure (43.4 %), and lighting intensity (40.0%). Biological hazards were poisonous exposure (31.8%) while ergonomic hazards including repetitive work (43.6%), manual material handling more than 10 kilogram per day (31.8%), prolonged sitting (35.7%) and standing (35.2%). The highest prevalence rates of work-related illnesses were back pain (63.7%) follow by upper extremities pain (50.5%), and heat exhaustion (33.4%). Conclusion: These findings provide a significant data for relevant authorities to develop occupational health and safety program. This is particularly engaging health and safety awareness in the workplace, leading to promote the quality of work life among elderly informal workers.