The COVID-19 pandemic has caused millions of infections and deaths worldwide, being critical to analyze derived mortality to guide the required control measures. Objective: To review the factors related to mortality from covid-19 with evidence in the scientific literature, with an emphasis on demographic variables and related comorbidities. Methodology: review of scientific literature by scoping review. Databases included: Scielo, Eumed, Dialnet, Medigraphic, Redalyc, Elsevier, Science Direct, Lilacs, Medline / Pubmed and academic google. 36 articles were identified with the inclusion criteria, 16 of which were of greater relevance. Results: In relation to demographic variables, mortality from COVID increases exponentially with age, the probability of dying is higher in men, and non-white ethnicity predicted a greater risk of critical admission, with the indigenous and Afro-descendant population significantly related to the increase. of cases and deaths. The most important risk factors for comorbidities for death from COVID-19 were: hypertension, diabetes, kidney disease, obesity, cirrhosis, active cancer and COPD. Conclusions: A challenge in public and community health is the identification and monitoring of populations with comorbidities that must be treated with quality, relevance and continuity, as a control measure aimed at reducing the probability of deaths from Covid-19. Other relevant subgroups to consider to avoid inequitable differences are indigenous and Afro-descendant groups.