Environmental, Health & Safety integrated management systems are widespread in manufacturing industries, despite limitations regarding the system efficiency and performance, especially concerning technical and behavioral factors. The Functional Safety tool can collaborate with better results in the implementation of an integrated management system. This study aims to identify attributes, and barriers in the studies of integrating functional safety and Environmental, Health, & Safety with sustainability and management systems. A systematic literature review was carried out in three phases: i) selection of studies on the topic, ii) bibliometric analysis, and iii) content analysis. This review, done through 702 searched documents from the Scopus, Science Direct, and Web of Science databases, resulted in 84 documents after exclusion criteria and the inclusion of 16 documents via the Snowball method. As the main deliverables, this study listed 30 attributes for the implementation of an integrated management system. Moreover, 25 raised barriers to implementing a system that integrates environmental, health & safety, and functional safety can be used to support practitioners in the implementation of manufactures. Finally, as the main contribution, there is a survey of managerial implications on how to implement this integrated management system in manufacturing industries.