The study of symmetric structures based on quasigroups is relatively new and certain gaps can be found in the literature. In this paper, we want to fill one of these gaps. More precisely, in this work we study substitution permutation networks based on quasigroups that make use of permutation layers that are non-linear relative to the quasigroup operation. We prove that for quasigroups isotopic with a group $\mathbb{G}$, the complexity of mounting a differential attack against this type of substitution permutation network is the same as attacking another symmetric structure based on $\mathbb{G}$. The resulting structure is interesting and new, and we hope that it will form the basis for future secure block ciphers.