Thermal resistance is the main informative characteristic when monitoring the quality of insulating materials and the thermal stability of enclosing structures. In particular, the actual values of thermal resistance as a key indicator are important in the assessment of the energy efficiency of the building. This work describes the information-measuring system for monitoring the ther-mal resistance of the building enclosure constructions. A scheme for modular construction of the system using various data transmission technologies has been proposed. For the registration of monitoring parameters, specially-designed sen-sors of heat flux and temperature have been applied. Provided solutions gives possibilities for measuring thermal resistance in 2 ... 40 zones simultaneously and monitoring of enclosing building constructions of complex shape. An experimental prototype of the system was created and a software module for registration and processing of measurement information was developed. The combined method for the experimental determination of the buildings enclo-sure constructions thermal resistance is proposed, and the procedures for carrying out measurements necessary for the qualitative and quantitative analysis of the thermal protection of the building enclosure according to ISO 6781: 2015 and ISO 9869: 2014 are described. The results of thermal resistance measurements for various types of building con-structions are presented. The reliability of the obtained results is confirmed by tests carried out in the la-boratory whose quality control system is certified according to ISO 17025