The environmental situation in the Khmelnytskyi oblast has been analyzed, models and forecasts of indicators have been developed by methods of extrapolation, regression analysis and trend models, and the quality of forecasting has been estimated. Namely, the models of influence of selected factors on the environmental situation in the Khmelnytskyi oblast have been developed. One- and multifactorial regression models have been constructed, conclusions about the degree of influence of factors have been made. Trend models of indicators of the ecological situation in the region have been constructed. Estimates of pollutant emissions, indicators of the creation and disposal of hazardous waste have been developed using different forecasting methods. These calculations can be used to carry out activities aimed at protecting the environment.