The integrated course "Science" is being introduced into school curricula in Ukraine for the first time. The article analyzes the experience of implementing an integrated course "Science" in schools of Ukraine. The advantages and disadvantages of various curriculum projects of the integrated course "Science" are discussed. The analysis of the content of the project №2 of the curriculum of the integrated course "Science" is made. Based on the results of two years of work on the implementation of the experimental integrated course "Science" in the profile school, the analysis of the main problems that arose during the implementation of this course and discusses possible ways to solve them.