The study presents a risk analysis to assist in choosing purified water design by osmosis reverse installations in health and biological research establishments. The process of producing and distributing purified water is sensitive in terms of contamination by microorganisms and electrical conductivity when considering the flow regime and the risk of standing water in the pipeline. Several risks are present in the design of installations for the production and distribution of purified water. Those responsible for a correct choice of the purified water production system should be taken in response to risks. As a methodological approach, research in standards and regulations was conducted, risk analysis was performed in the treated water purification process and distribution projects, AHP was used to prioritize the risks, and GTST was used to define the actions as responses to risks. Identifying the technologies available from different suppliers are factor considered necessary in the process. The results show the enormous source of uncertainty in the normal processes of production and distribution of purified water, with different regulations, which can compromise the integrity of the project, the sustainability, and the assertiveness of the delivery of the work. A risk analysis conducted as a global enterprise strategy to complement the risk analyzes of isolated disciplines can mitigate substantial risks and identify intangible risks. It increases the enterprise's certainty, legitimacy, and adequate application of public resources. The research points out that the production and distribution of purified water for laboratories are susceptible to contamination. It can make the enterprise unfeasible. The study contributes in two ways. First, it provides elements for identifying a safe production and distribution technology. Second, it contributes to developing a risk analysis based on decision trees that can be used in future projects for other purposes.