The ankle-brachial index (ABI) is a crucial non- invasive diagnostic parameter in the diagnosis of peripheral arterial disease (PAD). The classic techniques used to obtain this index have several limitations, such as the need to use Doppler equipment, patient discomfort, and the time required to perform the test. In recent years, several studies have been conducted with the aim of mitigating these restrictions, including obtaining this index based on pulse wave velocity with biomedical signals such as the combination of ECG and PPG. These systems have been developed for clinical environments and use wired connections. This paper proposes an improved version of this previous methodology, incorporating real-time wireless data transmission to a mobile device and subsequent storage in a remote database, from which ABI values are estimated, with the aim of increasing the portability of the system and improving its applicability in domestic environments. The importance of home monitoring is justified by continuous tracking and data collection for the future development of predictive models. The new system was evaluated through a comparative study between the traditional method, the previous wired approach, and the new wireless solution in a clinical setting with 25 diabetic patients susceptible to PAD complications. The results show good accuracy, confirming its usefulness as a home-based alternative for measuring ABI, although further optimization is required.