In 2025, the Hub of Bioinformatics and Biostatistics of the Institut Pasteur (the Hub) celebrates its 10th anniversary. Created to centralize bioinformaticians and biostatisticians scattered across campus, the Hub aims to pool resources and promote collaboration. It has become a key group supporting computational biology research through expert guidance, training, tool development, and building a community of specialists. Over the last decade, the Hub has collaborated with 200 research units on over 800 projects, combining its diverse expertise. This work resulted in more than 500 peer-reviewed publications, nearly 50 computational tools, and 30 deployed websites and portals. Additionally, the Hub established a dedicated PhD program and provided over 3,000 trainings. It tailored courses and mentoring programs for the Pasteur network and became integrated into the French bioinformatics landscape, co-organising events like the IFB Bioinformatics School and workshops on single-cell data analysis. The hub adopts a hub-and-spoke model with over 40 core members divides into five groups. Another 30 engineers are assigned to research units and transmissible disease surveillance labs for five-years renewable detachments, contributing 20% of their time to the Hub activities. Systems like weekly open-desks, project management tools, and steering committees ensure effective collaboration and address diverse scientific needs. The Hub has fulfilled its initial goals, supporting research and enabling knowledge exchange among computational biologists. It reduces isolated workloads and offers flexible career opportunities for research engineers. Its first decade highlights valuable lessons in governance, operational models, methodology development and outreach. The Hub looks forward for addressing challenges like innovation, career growth and time management as computational biology continues to evolve rapidly, while preparing for impactful next ten years.