This paper presents a low cost, versatile, organ perfusion machine designed for use in research. The modular and adaptable nature of the system allows for additional sensing equipment to be added or adapted for specific use. A proportional-integral-derivative (PID) controller was implemented and tested on a porcine liver to maintain input pressure of the perfusate into the hepatic artery (HA). The results confirmed the effectiveness of the controller for maintaining input through the HA in a timely manner.