Program for Monday, July 19th: Talk View

PROGRAM FOR MONDAY, JULY 19TH: TALK VIEW

Days:

next day

all days

View: with abstracts session overview

13:00

13:30

14:00

14:30

15:00

15:30

16:00

16:30

17:00

17:30

18:00

18:30

19:00

13:00-14:00

THE JOY OF PSEUDO-VALUES

Per Kragh Andersen

14:00-14:30

An early-phase clinical trial design in oncology with generalization ability

Shinjo Yada, Ryuji Uozumi

A flipped classroom approach for teaching medical statistics and statistical software training

Andreas Allgöwer, Rainer Muche, Ulrike Braisch, Marianne Meule, Benjamin Mayer

A comparison of dual biomarker threshold identification procedures within a confirmatory clinical

Ben Lanza, Chris Harbron, Nigel Stallard, Deepak Parashar

Multifactor intervention efficacy on MACE and mortality in diabetic kidney disease: a cluster-randomized controlled

Pafundi, Simeon, Chiodini, De Nicola, Galiero, Minutolo, Sasso

Challenges in Factorial Design Randomized Control Trials

Marian, Dutton, Virdee, Mansouri, Peckham, Hopewell, Chester-Jones

Non-inferiority trials with indirect evidence of assay sensitivity using network meta-analysis

Eisuke Hida, Toshiro Tango

Biomarker-based Bayesian randomized clinical trial for population finding with efficient reduction of sample

Akiyoshi Nakakura, Satoshi Morita, Yasuo Sugitani, Hideharu Yamamoto

A methodological review of phase I designs with late-onset toxicities and incomplete follow-up

Zhulin Yin, Christina Yap, Adrian Mander

Patient-specific dose finding in seamless phase I/II clinical trials

M. Iftakhar Alam, Shantonu Islam

The true power of clinical trials in pediatric cancers and other rare diseases

Audrey Mauguen

Outcomes reported in randomized clinical trials of depression in geriatric patients: a methodological

M. Rodrigues, A. D’elia, S. Sanger, S. Parpia, L. Thabane, Z. Samaan

One small clinical trial design to provide additional evidence of treatment effects than single-arm

Akimitsu Miyake, Tomoharu Sato, Tomomi Yamada, Eisuke Hida

SteppedPower - an R Package for Power Calculation in Stepped Wedge Cluster Randomised Designs

Philipp Mildenberger, Jochem König

Investigating the operating characteristics of clinical trials with borrowing from external data

Annette Kopp-Schneider, Silvia Calderazzo, Manuel Wiesenfarth

Introducing GINGER - a General simulation-INterpolation tool for designing multiGroup ExpeRiments

Lena Jiricka, Georg Heinze

Substitution of study control group by historic controls: Effect on study results using the example pain therapy for

Marius Sieverding, Christoph Gerlinger, Christian Seitz

Design optimization and intermediate safety reporting for a randomized controlled biomarker trial

Andrej Schwabe, Jan Wiemer

Using routinely collected data to conduct a pragmatic randomized controlled trial: an example addressing antibiotic prescription and resistance monitoring in Swiss primary

Florian Halbeisen, Heiner Bucher, Soheila Aghlmandi

Statistical considerations in using a novel consensus building technique to estimate action thresholds in clinical decision

Isabel Brosius, Alfred Kipyegon Keter, Lutgarde Lynen, Bart K.M. Jacobs

Flexible software framework to compare Bayesian hierarchical models across basket trial designs

Stephan Wojciekowski

Assessment of Clinical Trial Missing Data During a Pandemic: A Tipping Point Analysis Case Study

Nicole Close

14:00-14:30

A comparison of multiple imputation strategies for handling missing data in repeatedly measured multi-item

Rheanna Mainzer, Jemishabye Apajee, Cattram Nguyen, John Carlin, Katherine Lee

A Hidden Markov model segmentation to identify trajectories in sleep apnoea patients

A. Midelet, S. Bailly, J.-L. Pépin, R. Le Hy, M.-C. Schaeffer

A comparison of statistical methods to compensate for missing data in longitudinal cluster-randomised

Courtney McDermott, Ricardo Segurado, Mary Codd

Effect of impaired vision on physical activity from childhood to adolescence

L.A. Horvat-Gitsels, M. Cortina-Borja, A.O. Solebo, J.S. Rahi

Predictors of Multidrug Resistance in Nosocomial Pneumonia among Intensive Care Units’ Patients of a Tertiary Hospital,

Mina Yakoub, Fayek Elkhwsky, Iman El Sayed, Ayman El Tayar

Modelling of longitudinal data to predict cardiovascular disease risk: a methodological review

D. Stevens, R. Kolamunnage-Dona, S. Harrison, D. Lane, G. Lip

Impact of model misspecification on model-based bioequivalence

Guhl et.al

Cluster randomised controlled trial of lifestyle intervention for adolescents’ health using ‘SPRAT’

K. Yamaoka, J. Watanabe, M. Watanabe, M. Adachi, A. Nemoto, T. Tango

Assessing the role of hyperventilation in patients with traumatic brain injury: longitudinal data analysis from the

Matteo Petrosino

A new approach to measure frailty in the context of COVID-19 population

F. Graziano, S. Galimberti, P. Rebora, P. Mazzola, G. Bellelli, M.G. Valsecchi

Pain Management in Immediate Life Support Ambulances

Mauro Mota, Carla Henriques, Ana Cristina Matos

Statistical methods for estimating sources of variability in count-based biomarkers

Kostas Tryposkiadis, Alice Sitch, Malcolm Price, Jon Deeks

Longitudinal progression of frailty in older population and risk of adverse events: An application of joint

Elhussein, Robinson, Delmestri, Prieto-Alhambra, Silman, Strauss

Semi-variogram approach to estimate within-subject variability in repeated measurements

Simon Baldwin, Alice Sitch, Yemisi Takwoingi, Jonathan J Deeks

Non-linear dynamic indices summarize densely sampled longitudinal data

Mireya Diaz

Kernel density estimation for circular data about COVID-19 in the Czech Republic

Stanislav Katina, Stanislav Zámečník, Ivana Horová

Functional analysis of temporal data about patient’s health condition after total knee replacement

Markéta Janošová, Stanislav Katina, Libor Nečas

Multivariate Analysis of Blood Biomarkers in Amyotrophic Lateral Sclerosis

S. Yazdani, C. Seitz, A. Lovik, J. Andersson, C. Ingre, F. Fang

Possibilities and challenges when analysing large longitudinal data from a population based Norwegian registry (MoBa

M. Cvancarova Smastuen, L. Valla, N. Misvær, R. Andenæs, S. Helseth

Estimating time to confirmed disease progression in observational data sources with irregular visit

T. Debray, M. Copetti, R. Platt, G. Simoneau, C. Shen, F. Pellegrini, C. de Moor

14:45-16:15

Nowcasting the spread of COVID-19 to inform control policies in Hong Kong

Joseph Wu

14:45-16:15

Statistical challenges in the monitoring of the SARS-CoV-2 pandemic

Daniela De Angelis

14:45-16:15

Modelling the COVID-19 pandemic: initial introduction, lockdown assessment, phasing out

Pierre-Yves Boëlle

14:45-16:15

How to deal with collider bias in Mendelian randomization analysis?

Claudia Coscia, Teresa Pérez, Núria Malats, Stephen Burgess

14:45-16:15

The impact of instruments’ selection on Mendelian randomization results: a case study

Daniele Bottigliengo, Amke Caliebe, Inke R. König, Fabiola Del Greco M.

14:45-16:15

Caution When Inferring the Effect Direction in Mendelian Randomization

Sharon Lutz, Stijn Vansteelandt, Christoph Lange

14:45-16:15

Tying research question and analytical strategy when variables are affected by medication use

Jungyeon Choi, Olaf Dekkers, Saskia le Cessie

14:45-16:15

Identification of causal effects in case-control studies

Bas Penning de Vries, Rolf Groenwold

14:45-16:15

Modular components in basket trials and connections among the applied tools

Moritz Pohl, Johannes Krisam, Meinhard Kieser

14:45-16:15

Seamless Master Protocol with account for correlations within subgroups

Benjamin Duputel, Sarah Zohar, François Montestruc, Moreno Ursino

14:45-16:15

Monotonicity Rules for Inference in Basket Trials

Lukas Baumann, Johannes Krisam, Meinhard Kieser

14:45-16:15

Response-adaptive randomization in clinical trials: from myths to practical considerations

David Robertson, Kim Lee, Boryana Lopez-Kolkovska, Sofia Villar

14:45-16:15

Treatment allocation strategies for umbrella trials in the presence of multiple biomarkers: A comparison of

Luke Ouma, Michael Grayling, Haiyan Zheng, James Wason

14:45-16:15

Loop-splitting in network meta-analysis: a new approach to evaluating loop inconsistency

B. Turner, T. Band, T. Morris, D. Fisher, J. Carpenter, J. Higgins, I. White

14:45-16:15

Decision curve analysis for treatment benefit in a network meta-analysis framework

Konstantina Chalkou, Georgia Salanti

14:45-16:15

The Risk Of Bias due to Missing Evidence in Network meta-analysis (ROB-MEN) tool: web application and implementation in a network of antidepressant

Chiocchia et.al

14:45-16:15

Network meta-analysis and random walks

A. Davies, T. Papakonstantinou, A. Nikolakopoulou, G. Ruecker, T. Galla

14:45-16:15

Bayesian network meta-analysis methods for combining IPD and aggregate data from single-arm studies and

J. Singh, S. Gsteiger, C. Gillies, K. Abrams, S. Bujkiewicz

14:45-16:15

ATLASQTL and EPISPOT: two joint hierarchical approaches for detecting and interpreting hotspots in molecular QTL

Hélène Ruffieux, Leonardo Bottolo, Benjamin Fairfax, Sylvia Richardson

14:45-16:15

Explained Variation in the Linear Mixed Model

Nicholas Schreck

14:45-16:15

Reconstructing KIR haplotypes taking ambiguous and missing data into account

van der Burg, de Wreede, Baldauf, Sauter, Schetelig, Putter, Böhringer

14:45-16:15

COMET: an R package to identify sample cross-contamination in whole genome sequencing studies

Alexandre Thiéry, Tanja Zeller, Stefan Blankenberg, Andreas Ziegler

14:45-16:15

Evaluating DNA sequencing performance: concordance-discordance model and latent class model

Y. Zhai, A. Herzig, C. Bardel, D. Sanlaville, E. Genin, P. Roy

14:45-16:15

Confidence intervals for the treatment effect in the Magnusson-Turnbull adaptive enrichment design

Jinyu Zhu, Andrew Titman, Fang Wan

14:45-16:15

Graphical approaches for the control of generalized error rates

Frank Bretz, David Robertson, James Wason

14:45-16:15

Evaluation of the Fill-it-up design to combine data from observational trials and RCTs

Stephanie Wied, Ralf-Dieter Hilgers, Nicole Heussen

14:45-16:15

Improved group sequential Holm procedures for testing multiple correlated hypotheses over time

Julia Niewczas, Fredrik Öhrn, Carl-Fredrik Burman

14:45-16:15

Randomization tests to address disruptions in clinical trials

Diane Uschner

14:45-16:15

Testing for ignorable sampling bias under random double truncation

Jacobo de Uña-Álvarez

14:45-16:15

A martingale based approach for modelling the alternating recurrences in Cystic Fibrosis patients

Moumita Chatterjee

14:45-16:15

Impact of measurement error in time-varying prescription-based drug exposures in time-to-event

Steve Ferreira Guerra, Robert Platt, Michal Abrahamowicz

14:45-16:15

Developing a Goodness of fit test for a joint model: The case of clustered survival and count data

Marina Roshini Sooriyarachchi, Nayani Adikari

14:45-16:15

Confidence bands of the MRL function in some right censored prevalent cohort studies via the empirical

Ali Shariati, Hassan Doosti, Justin Wishart

14:45-16:15

Bayesian multi-response nonlinear mixed-effect model: application of two recent HIV infection

C. Castel, C. Sommen, E. Chatignoux, Y. Le Strat, A. Alioum

14:45-16:15

Confidence, Prediction, Tolerance Intervals in Linear Mixed Models: Applications in (Non)-Clinical

Bernard Francq, Dan Lin

14:45-16:15

Bayesian multivariate longitudinal data analysis assuming different association structures

A. Lika, D. Rizopoulos, M. Kruijshaar, A. Van der Ploeg, E. Andrinopoulou

14:45-16:15

The use of mixed logistic modelling in the analysis of HIV latency study data in the context of low sample size and low outcome

Hannah Morgan, Bethany Horsburgh, Bonnie Heiner, Sarah Palmer, Timothy Schlub

14:45-16:15

Mixed Modeling of Regional Infant Mortality Data over Twenty Years in North Rhine-Westphalia.

Noor Jahan Akter, Dankmar Böhning

16:15-16:45

STATISTICAL METHODS TO ANALYSE ORDINAL CATEGORICAL DATA ARISING FROM THE CLINICAL TRIAL OF DRUGS FROM THE PHARMACEUTICAL

Nazneen Shariff

Causal inference with skewed outcome data: Moving beyond the “ignore or transform” approach

Daisy Shepherd, Margarita Moreno-Betancur

Marginal Structural Models with Latent Class Growth Modeling of Time-varying Treatment.

Awa Diop, Caroline Sirois, Denis Talbot

Multidimensional mediators: Comparison between statistical methods using Data simulation

Nadia Dardenne, Anne-Françoise Donneau

The role of the matching algorithm in an analysis of the effect of hemoadsorption in patients with

Priska Heinz, Pedro David Wendel Garcia, Ulrike Held

Estimating the causal effect of direct-acting antiviral agents on kidney function in a clinical cohort of chronic Hepatitis C

Adrienne O'Donnell, Nathan Pham, Leandra Battisti, Sara Lodi

Should multiple imputation be stratified by exposure when estimating causal effects via outcome

J. Zhang, S.G. Dashti, J.B. Carlin, K.J. Lee, M. Moreno-Betancur

Pathways to inequalities in child mortality: a population level study in Wales

Schlüter, Lai, Abbasizanjani, Griffiths, Akbari, Taylor-Robinson

Target Trial Emulation and Missing Eligibility Data: A study of Palivizumab for child respiratory

Daniel Tompsett, Bianca De Stavola, Ania Zylbersztejn, Pia Hardelid

Targeted causal quantile estimation for measurement of postdischarge opioid use in a text-to-web

Kennedy, Scalise, Robinson, Booth, Marwaha, Fleishman, Brat

Does early weight gain mediate the causal effects of severity and duration of depression on the onset of metabolic

K. El Asmar, S. El Omari, B. Falissard, R. Colle, L. Becquemont, E. Corruble

Pathway specific population attributable fractions.

Maurice O'Connell, John Ferguson

17:00-18:30

Personalized Schedules for Invasive Diagnostic Tests: With Applications in Surveillance of Chronic

A. Tomer, D. Nieboer, M. Roobol, E. Steyerberg, D. Rizopoulos

17:00-18:30

Comparing risk prediction models in longitudinal context

Liang Li

17:00-18:30

Testing for Heterogeneity in the Utility of a Surrogate Marker

Layla Parast, Lu Tian, Tianxi Cai

17:00-18:30

Nonlinear mediation analysis with high‐dimensional mediators whose causal structure is unknown

Wen Wei Loh, Beatrijs Moerkerke, Tom Loeys, Stijn Vansteelandt

17:00-18:30

Separable Causal Effects as alternative Estimands in Epidemiology and Biostatistics

Vanessa Didelez

17:00-18:30

Simulating hypothetical interventions on multiple mediators: Extending methods and practical

Margarita Moreno-Betancur, John B Carlin

17:00-18:30

Mediation with a survival outcome and time-varying mediator: empirical comparison and use in observational

Kamaryn T. Tanner, Linda D. Sharples, Rhian M. Daniel, Ruth H. Keogh

17:00-18:30

Mediation with Irregular Longitudinal Biomarkers: An Application to Examining Obesity and Severe Disease in COVID-19

David Cheng, Andrea Foulkes

17:00-18:30

Early completion of phase I cancer clinical trials with Bayesian optimal interval design

Masahiro Kojima

17:00-18:30

Decision rules for identifying combination therapies in open-entry, randomized controlled platform

E.L. Meyer, P. Mesenbrink, C. Dunger-Baldauf, E. Glimm, Y. Li, F. König

17:00-18:30

A Bayesian decision-theoretic approach to outcome-adaptive sequential multiple assignment randomised trials (SMARTs) with distinct intermediate binary

Robert Mahar, Julie Simpson, Bibhas Chakraborty, Agus Salim

17:00-18:30

Modelling time varying recruitment rates and site activation prediction in multicentre clinical trials: A comparison

Aris Perperoglou, Szymon Urbas, Youyi Zhang, Kevin Quach

17:00-18:30

Compromise Bayesian test decisions under type I error rate constraint

Silvia Calderazzo, Annette Kopp-Schneider

17:00-18:30

Dynamic predictive modelling of the first wave of the COVID-19 pandemic in Canada using a deterministic density-dependent susceptible-exposed-infected-recovered (SEIR) model that accounts for age-stratified ageing, reporting delays and mortality

Ornella Wafo Noubissie

17:00-18:30

Nowcasting CoVID-19 Deaths in England by Age and Region

Shaun Seaman, Pantelis Samartsidis, Meaghan Kall, Daniela De Angelis

17:00-18:30

An evaluation of the stability, precision and performance of phenomenological models applied to COVID-19 cases and deaths in South

Charl Janse van Rensburg, Tarylee Reddy, Ziv Shkedy, Samuel Manda

17:00-18:30

Estimation of incubation time and latency time distribution of SARS-CoV-2: the impact of distributional

Vera Arntzen, Marta Fiocco, Ronald Geskus

17:00-18:30

Regional estimates of reproduction numbers with application to COVID-19

Stefan Heyder, Thomas Hotz, Tyll Krüger, Jan Pablo Burgard

17:00-18:30

Quantifying the robustness of primary analysis results: a case study on missing outcome data in pairwise and network

Loukia Spineli, Chrysostomos Kalyvas, Katerina Papadimitropoulou

17:00-18:30

Meta-analysis of randomised trials with continuous outcomes: methods that adjust for baseline should be

K. Papadimitropoulou, R.D. Riley, O.M. Dekkers, T. Stijnen, S. le Cessie

17:00-18:30

Flexible generic framework for evidence synthesis in health technology assessment

Hamza et.al

17:00-18:30

Component Network Meta-Analysis Including Individual Participant Data and Summary Aggregate Data

Ellesha Smith, Laura Gray, Suzanne Freeman, Keith Abrams, Stephanie Hubbard

17:00-18:30

Bayesian multivariate network meta-analysis model for the difference in restricted mean survival

Xiaoyu Tang, Ludovic Trinquart

17:00-18:30

Phases of methodological research in biostatistics – a proposal to increase transparency and

Georg Heinze, Anne-Laure Boulesteix, Michael Kammer, Tim Morris, Ian R. White

17:00-18:30

The p-value conundrum: how can a Bayesian analysis help? A case study in reproductive and maternal-fetal

Karla Hemming, Monica Taljaard

17:00-18:30

On the marginality principle, with a focus on ratios and interactions

Tim Morris, Maarten van Smeden, Andrew Althouse, Darren Dahly, Tra My Pham

17:00-18:30

An extension to reporting guidelines for systematic reviews of prediction model studies

Snell, Levis, Debray, Hooft, Dhiman, Reitsma, Moons, Collins, Riley

17:00-18:30

Reference based multiple imputation for trials – what’s the right variance and how to estimate

Jonathan Bartlett

17:00-18:30

Immortal time bias for life-long conditions in retrospective observational studies using electronic heath

Freya Tyrer, Krishnan Bhaskaran, Mark J Rutherford

17:00-18:30

Identifying high-risk groups for BMI change using electronic health records from 2.3 million adults

Katsoulis et.al

17:00-18:30

Multiple imputation of sporadically-missing continuous time data by Brownian bridge stochastic

C. Everett, R. Walwyn, J. Brown, L. Bogachev, J. Houwing-Duistermaat, D. Stocken

17:00-18:30

Handling missing data from wearable devices in clinical trials

M. Tackney, D.G. Cook, D. Stahl, K. Ismail, E. Williamson, J. Carpenter

17:00-18:30

Using wristwear device to assess impact of COVID19 lockdown on physical activity

Agus Salim, Christian Brakenridge, David Dunstan, Neville Owen

17:00-18:30

Prostate cancer intratumor heterogeneity assessment by depth measures analysis on imaging texture

L. Cavinato, A. Ragni, F. Ieva, M. Sollini, F. Bartoli, P. Erba

17:00-18:30

Investigating Down syndrome by integrating methylation and glycomics using supervised PO2PLS

Zhujie Gu, Said El Bouhaddani, Jeanne Houwing-Duistermaat, Hae-Won Uh

17:00-18:30

Model selection characteristics when using MCP-Mod for dose-response gene expression data

Julia Duda, Franziska Kappenberg, Jörg Rahnenführer

17:00-18:30

Information sharing across genes for improved parameter estimation in dose-response curves

Franziska Kappenberg, Jörg Rahnenführer

17:00-18:30

A Bayesian approach to estimating dynamic models of co-regulated gene expression

Sara Venkatraman, Sumanta Basu, Martin Wells, Myung-Hee Lee

18:30-19:00

A methodological approach to assess data quality from the Clinical Practice Research Datalink

Pradeep Virdee, Alice Fuller, Michael Jacobs, Tim Holt, Jacqueline Birks

Modeling Child Mortality in the presence of Clustering

Beryl Ang'Iro, Roel Braekers, Nelson Owuor

Nguyen’s Information Criteria (NIC)

Jean-Michel Nguyen

Long-term oral prednisolone exposure for bullous pemphigoid: a population-based study using ‘big data’ and missing data

Persson, Harman, Thomas, Chalmers, Vinogradova, Langan, Hippisley-Cox, Gran

Exploring risk stratification in cardiomyopathies using a deep learning approach for survival

I. Gandin, A. Paldino, A.P. d'Adamo, M. Dal Ferro, M. Merlo, G. Barbati

Can animal studies on rodents help better understand Alzheimer’s disease in humans?

Tereza Dračková, Stanislav Katina, Petra Majerová, Andrej Kováč

Non-linear and non-additive associations between the pregnancy exposome and birthweight

Colicino, Ferrari, Cowell, Niedzwiecki, Foppa Pedretti, Joshi, Wright, Wright

18:30-19:00

Machine learning to support Reinke’s edema diagnosis from voice recordings

M. Carmen Robustillo, Carlos J. Pérez, M. Isabel Parra, Mario Madruga

The Need for Expanded Standardized Reporting for Machine Learning Methods in Clinical Prediction

Kelly Reeve, Begum Irmak On Seker, Heidi Seibold, Ulrich Mansmann, Ulrike Held

Virtual biopsy in action: a radiomic-based model for CALI prediction

Ieva, Baroni, Cavinato, Masci, Costa, Fiz, Chiti, Viganò

Creation of adverse drug reactions assessment tool

Puronaitė et.al

Use of machine learning models combined with innovative interpretation methods to identify prognostic

Péan, Darbier, Ghorbal, Pau, Esnault, Gilberg, Dupin, Civet