Days: Friday, May 10th Saturday, May 11th Sunday, May 12th Monday, May 13th Tuesday, May 14th
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Symposia/Workshop presented by the Simons Initiative for the Developing Brain
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Special Lecture
Dr Carmen Sandi
18:00 | Mitochondrial function in the nucleus accumbens links anxiety with stress coping behaviors (abstract) |
Opening Reception
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Genetics & neurobiology of disordered eating
09:00 | Elucidation of Secretin in thirst regulation within subfornical organ neurons in the brain (abstract) |
09:20 | Forward genetic and gene validation studies of binge-like eating in mice: Sex-sensitive genetic loci, including male-specific linkage with the Tas2r locus (abstract) |
09:45 | Dopamine D2 receptor overexpression in the nucleus accumbens core indirect pathway increases activity-based anorexia selectively in female mice (abstract) |
10:10 | Taste reward circuitry in women remitted from anorexia nervosa and bulimia nervosa: hunger, satiety, and the motivation to eat (abstract) |
10:35 | Genome-wide association study of anorexia nervosa implicates metabolic and psychiatric origins (abstract) |
Outstanding Travel Awardees
11:30 | CLIP-seq analysis of the RNA binding protein hnRNP H in striatum following methamphetamine administration in Hnrnph1+/- mice (abstract) |
11:50 | Amygdala NPY circuits are critical for the development of accelerated obesity under chronic stress (abstract) |
12:10 | Alcohol causes lasting transcriptomic changes in the Drosophila mushroom body (abstract) |
Laterality and cognition
13:30 | Colony-level lateralisation of forelimb movements in wood ants (abstract) |
14:00 | Handedness and neurodevelopmental disorders: a genetic approach (abstract) |
14:20 | Behavioral laterality predicts fear avoidance responses but does not predict anxiety-related behavior in zebrafish (Danio rerio) (abstract) |
14:40 | Fish as animal models to explore the relation between anatomical and functional asymmetries (abstract) |
15:00 | Spontaneous and light induced brain lateralization of c-Fos expression in the newly-hatched chick (abstract) |
15:20 | What is the role of new-neurons in the development of individual behaviour? (abstract) |
Poster Session I
Odd Number Posters
15:30 | P1 – Reward sensitivity in Hnrnph1+/- mice following acute methamphetamine administration as measured via intracranial self-stimulation (abstract) |
15:30 | P3 – Role of epigenetic mechanisms in intergenerational effects of anesthesia with sevoflurane in young adult rats (abstract) |
15:30 | P5 – The Role of Glutamate-related Proteins in Genetic Risk for High Methamphetamine Intake (abstract) |
15:30 | P7 – Light duration changes locomotor response dependence on HPA axis signaling (abstract) |
15:30 | P9 – Molecular and neural mechanisms of alcohol-induced sleep disruption in Drosophila (abstract) |
15:30 | P11 – Transcriptomic analysis of differential treatment of Qi-dysregulation phenotypes revealed the participation of neuroengery in depression using Balb/cJ mouse strain (abstract) |
15:30 | P13 – Examining the Association Between Polygenic Risk Scores for Neuroticism and Extraversion, Cognitive Biases and Psychopathology Among Adolescents (abstract) |
15:30 | P15 – Different social behavior and oxytocin responses to acute methamphetamine treatment in juvenile female rats perinatally exposed to stress and/or drug administration (abstract) |
15:30 | P17 – Early-life low-level chronic lead (Pb) exposure alters anxiety-like behavior, but not alcohol intake, in adult C57BL/6J mice (abstract) |
15:30 | P19 – Longitudinal DNA methylation changes related to reinforcement psychopathology in adolescence (abstract) |
15:30 | P21 – Forced swim test and CB-1 receptor expression in hippocampus of offspring of obese male mice (abstract) |
15:30 | P23 – The Adult Neurogenesis Map (abstract) |
15:30 | P25 – The role of ErbB3 binding protein 1 (EBP1) in brain development and gene silencing control in mice (abstract) |
15:30 | P27 – Functional characterisation of ADHD-associated gene variants using the zebrafish as an animal model (abstract) |
15:30 | P29 – Natural polymorphism in protein kinase G modulates functional senescence in D. melanogaster (abstract) |
15:30 | P31 Using C. elegans social behaviour to investigate genes associated with autism spectrum disorder (abstract) |
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Genes-environment interactions in brain and behavior
09:00 | Learning is enhanced by tailoring instruction to individual genetic differences (abstract) |
09:30 | Individual differences govern cocaine-related neurobehavioral phenotypes (abstract) |
10:00 | Using a population-based mouse model for assessment of neurotoxicity in response to early-life lead exposure (abstract) |
10:30 | Gene-Environment Interactions in Neurotoxicology Research (abstract) |
11:00 | Gene-by-diet regulation of Alzheimer’s disease pathogenesis (abstract) |
Young Investigator Award
Dr. Zoe Donaldson
11:30 | Functional variation in neuromodulatory genes as a source of behavioral diversity (abstract) |
Themed Talks
Mood, Social interactions, cognition and learning.
13:30 | Early-life heat exposure influence resilience or vulnerability to heat stress later in life by an epigenetic mechanism (abstract) |
13:45 | The superior colliculus-mediodorsal thalamus-basolateral amygdala circuit underlies the psychotherapeutic regimen for fear disorders (abstract) |
14:00 | Kainate receptor auxiliary subunit NETO2 modulates maturity and excitability of amygdala (abstract) |
14:15 | Using C. elegans social behaviour to investigate genes associated with autism spectrum disorder (abstract) |
14:30 | Modeling WBS-related gene dosage effects on neuronal and social traits in Drosophila (abstract) |
14:45 | Neuropeptide modulation of aversion and reward during learning (abstract) |
15:00 | A forward genetic screen reveals the calcium-sensing GPCR CaSR as a novel modulator of larval sensorimotor decision-making (abstract) |
15:15 | Genetic and neural circuit analysis of the acoustic startle threshold (abstract) |
Professional Development Workshop
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Exposure to alcohol or other drugs of abuse during development
09:00 | Symposia Introduction (abstract) |
09:10 | Effect of Genetics on Neuroinflammatory Responses Following Neonatal Ethanol Exposure in BXD Mice (abstract) |
09:35 | Choline as a treatment for fetal alcohol spectrum disorders (abstract) |
10:10 | Behavioural effects of developmental exposure to the synthetic cannabinoid JWH-018 in wild type and disrupted in schizophrenia 1 (DISC1) mutant zebrafish (abstract) |
10:30 | Conditioned reward following edible ∆9-tetrahydrocannabinol (THC) consumption in adolescent and adult mice (abstract) |
10:55 | Symposia Discussion (abstract) |
Themed Talks
New or improved methodology
11:30 | Aberrant vesicular release in mice with a Vamp2 transmembrane mutation underlies striking sleep deficits (abstract) |
11:45 | Sequencing the BXD family, a cohort for experimental systems genetics and precision medicine (abstract) |
12:00 | Co-housing affects mouse activity rhythms in a genotype and sex specific manor (abstract) |
12:15 | Clustering the Spectrum: Finding Genetic Associations for Autism-related Traits (abstract) |
Distinguished Investigator Award
Dr. Seth Grant
13:30 | Searching for the molecular building blocks of behavior (abstract) |
Business Meeting
Poster Session II
Even Number Posters
15:30 | P2 – Glucocorticoid receptor dysregulation as a genetic risk factor for high-risk ethanol intake in HDID-1 mice (abstract) |
15:30 | P4 – The effect of dyslexia candidate genes on reading and language abilities in an adult population cohort (abstract) |
15:30 | P6 – Low-level embryonic exposure to methylmercury causes neurobehavioral impairment in larval and adult zebrafish (abstract) |
15:30 | P8 – From sleep to schizophrenia: Investigating the region-specific function of Zfhx3 in the mouse brain, and characterising its molecular activity (abstract) |
15:30 | P10 – Systematic analysis of brain pH and lactate levels in animal models: relationships and implications for behavioral outcomes (abstract) |
15:30 | P12 – Ultrasonic communication in the CB1 knockout mouse line during development and at adulthood (abstract) |
15:30 | P14 – Behavioural characterization of the MDGA2+/- mouse model of Autism spectrum disorder across the lifespan (abstract) |
15:30 | P16 – ICM-APATHY-TASKS: Developing a New Behavioral Tool to Explore the Three Underlying Mechanisms of Apathy (abstract) |
15:30 | P18 – The generalized and myoclonic seizures in Krushinsky-Molodkina rat strain (abstract) |
15:30 | P20 – ADOLESCENT SOCIAL STRESS INFLUENCES MORPHINE SENSITIZATION AND GENE EXPRESSION (abstract) |
15:30 | P22 – Does tolerance to ethanol-induced sedation explain the sensitized response to ethanol? (abstract) |
15:30 | P24 – Relative brain weight differences as the result of direct and indirect selection (abstract) |
15:30 | P26 – Sex Differences in Gene Expression Patterns Associated with the APOE4 Allele (abstract) |
15:30 | P28 – Heritability of aggression in human: what may be missed and included? (abstract) |
15:30 | P30 - Ovarian hormones causally contribute to the prophylactic efficacy of (R,S)-ketamine and (2R,6R)-hydroxynorketamine in female mice. (abstract) |
15:30 | P32 - Neuropeptide modulation of aversion and reward during learning (abstract) |
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Not just insulation: Oligodendrocyte function and myelination in behavior
09:00 | Myelinated axon plasticity and neural circuit function (abstract) |
09:25 | Long-lasting molecular and cellular effects of child abuse and depression on oligodendrocyte function (abstract) |
09:50 | Genetic control of myelin plasticity after chronic psychosocial stress (abstract) |
10:15 | Catatonia – starting to understand mechanisms involving myelin and neuroinflammation (abstract) |
10:40 | The developmental trajectory of functional connectivity and sensorimotor behavior in mice (abstract) |
Themed Talks
Drugs of abuse and addiction
11:30 | Alcohol Related Behaviors in Mice Selectively Bred for High and Low Activity (abstract) |
11:45 | Glyoxalase 1 involvement in ethanol reward sensitivity and ethanol withdrawal (abstract) |
12:00 | Genetic differences between BALB/cJ and BALB/cByJ substrains in opioid state-dependent reward learning, spontaneous withdrawal, and weight loss in response to oxycodone: Planting the seeds for a reduced complexity cross (abstract) |
12:15 | Systems genetic analysis of nicotine withdrawal deficits in learning (abstract) |
Molecules and connected cells
13:30 | Genetic dissection of postsynaptic function in behaviour and physiology (abstract) |
14:00 | Time-course transcriptome created by next-generation sequencing to find coding and non-coding genes involved in cerebellar development and function (abstract) |
14:30 | Systematic phenomics analysis of ASD-associated genes defines novel shared and unique functions and identifies parallel genetic networks underlying hypersensitivity and impaired habituation (abstract) |
15:00 | Network topology analysis of the synaptic proteome reveals molecular substructures associated with neurodevelopment, autism and intellectual ability (abstract) |
15:30 | Developmental disruption of locus coeruleus-norepinephrine signaling results in male-specific behavioral phenotypes relevant to neurodevelopmental disorders (abstract) |
Presidential Lecture
Dr. William Schafer
16:00 | The neuromodulatory connectomes of C. elegans (abstract) |
Banquet Dynamic Earth