PROGRAM
Days: Tuesday, May 17th Wednesday, May 18th Thursday, May 19th Friday, May 20th
Tuesday, May 17th
View this program: with abstractssession overviewtalk overview
13:00-14:00Lunch Break
17:30-19:00 Session 5A: Opening Ceremony
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Location: Effectenbeurszaal
17:30 | Welcome Address |
17:40 | Welcome Address |
17:50 | Welcome Address |
18:00 | Julia Bodmer Award |
18:20 | HLA Award |
18:30 | Ceppellini Lecture |
19:00-21:00 Welcome Reception
Location: Grote Zaal
Wednesday, May 18th
View this program: with abstractssession overviewtalk overview
08:30-10:00 Session 6A: Plenary session: Tolerance in Solid Organ Transplantation
Chairs:
Location: Effectenbeurszaal
08:30-10:00 Session 6B: Plenary session: Tolerance in Solid Organ Transplantation (Screened)
Location: Graanbeurszaal
10:00-10:30Coffee Break
10:30-12:00 Session 8A: Special Joint Session: EBMT and EFI
Chairs:
Harry Dolstra (Radboud University Medical Center, Netherlands)
Katharina Fleischhauer (University Hospital Essen, Germany)
Katharina Fleischhauer (University Hospital Essen, Germany)
Location: Effectenbeurszaal
10:30 | Integrated HLA-DPB1 permissiveness models in stem cell transplantation |
11:00 | CAR-T cell therapy: allogeneic versus autologous |
11:30 | Allogeneic (CAR)NK-cell adoptive transfer |
10:30-12:00 Session 8B: Teaching Session: Donor-specific HLA Antibodies - What Can Be Accepted?
Chairs:
Ann-Margaret Little (NHS, UK)
Stefan Schaub (University of Basel, Switzerland)
Malte Ziemann (University Hospital of Schleswig-Holstein, Germany)
Stefan Schaub (University of Basel, Switzerland)
Malte Ziemann (University Hospital of Schleswig-Holstein, Germany)
Location: Graanbeurszaal
10:30 | Methods for donor HLA antibody detection |
11:00 | DSA: what is acceptable in stem cell transplantation? |
11:30 | DSA: what is acceptable in solid organ transplantation? |
10:30-12:00 Session 8C: Abstract Session: Solid Organ Transplantation 1 (O9-O16)
Chairs:
Gottfried Fischer (Medical University of Vienna, Austria)
Kirsten Geneugelijk (University Medical Center Utrecht, Netherlands)
Kirsten Geneugelijk (University Medical Center Utrecht, Netherlands)
Location: Veilingzaal
10:30 | Molecular signatures for acute renal allograft rejection: long non coding RNAs as potential biomarkers (abstract) PRESENTER: Uma Kanga |
10:40 | Effects of Natural Killer cell alloreactivity on allograft failure in kidney transplantation (abstract) PRESENTER: Burcu Duygu |
10:50 | A comprehensive evaluation of the antibody-verified status of eplets listed in the HLA Epitope Registry (abstract) PRESENTER: Suzanne Bezstarosti |
11:00 | Multi-Panel High-Dimensional Immunophenotyping of a Longitudinal Renal Transplant Cohort (abstract) PRESENTER: Franz Fenninger |
11:10 | HLA antibody affinity assessment: from mAb to DSA (abstract) PRESENTER: Gideon Hoenger |
11:20 | The pre-transplant non-HLA antibody burden predicts the development of histology of antibody-mediated rejection after kidney transplantation (abstract) PRESENTER: Aleksandar Senev |
11:30 | T-cell epitopes shared between immunizing and donor HLA associate with kidney allograft failure (abstract) PRESENTER: Emma Peereboom |
11:40 | Predictive value of the evolution of de novo DSA MFI values in kidney transplantation (abstract) PRESENTER: Covadonga López del Moral |
10:30-12:00 Session 8D: Abstract session: NK cells and Reproductive Immunology (O17-O24)
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Chairs:
John Trowsdale (Cambridge University, UK)
Lotte Wieten (Maastricht University Medical Center, Netherlands)
Lotte Wieten (Maastricht University Medical Center, Netherlands)
Location: Administratiezaal
10:30 | Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes (abstract) PRESENTER: Laura Mora-Bitria |
10:40 | Human group A and B KIR haplotypes are mirrored by inhibitory and activating KIR profiles in rhesus macaques (abstract) PRESENTER: Nanine de Groot |
10:50 | Application of the major predictive scoring strategies assessing KIR-based NK alloreactivity in donor/recipient couples (abstract) PRESENTER: Adèle Dhuyser |
11:00 | Streamlining the discovery of new alleles for killer-cell Immunoglobulin-like receptor (KIR) genes (abstract) PRESENTER: Luciana De Brito Vargas |
11:10 | Beyond KIR: A novel next-generation sequencing method for the complete NK cell receptome (abstract) PRESENTER: Danillo Augusto |
11:20 | Interpreting Killer-cell Immunoglobulin-like Receptor Whole Genome Sequence Data with PING (abstract) PRESENTER: Wesley Marin |
11:30 | Visualizing the prevalence and interactions of maternal immune cells and fetal trophoblasts using imaging mass cytometry: the prominence of myeloid cells (abstract) PRESENTER: Juliette Krop |
11:40 | Inflammatory pathology lesions in the placenta are specifically observed in uncomplicated pregnancies after oocyte donation and are associated with fetal-maternal HLA mismatching (abstract) PRESENTER: Xuezi Tian |
10:30-12:00 Session 8E: Hands On Teaching Session: Bioinformatics - molecular Mismatch Tools in Practice
Chairs:
Ben Matern (University Medical Center Utrecht, Netherlands)
James Robinson (Anthony Nolan Research Institute, UK)
James Robinson (Anthony Nolan Research Institute, UK)
Location: Berlagezaal
10:30 | Case studies with PIRCHE and HLA-EMMA |
11:00 | Case studies with PIRCHE and HLA-EMMA |
11:30 | Case studies with PIRCHE and HLA-EMMA |
12:00-13:00Lunch Break
14:00-15:30 Session 11A: Teaching Session: Non-HLA Antibodies: How Permissible Are They in Transplant Settings?
Chair:
Henny Otten (UMC Utrecht, Netherlands)
Location: Effectenbeurszaal
14:00-15:30 Session 11B: Abstract Session: Immunotherapy, Gene Therapy and New Technologies (O25-O32)
Chairs:
Location: Graanbeurszaal
14:00 | Patient-derived 3D-organoids to study combination therapies of NK cells and antibody-dependent cellular cytotoxicity-inducing antibodies in pancreatic cancer (abstract) PRESENTER: Nicky Beelen |
14:10 | HLA-DP-restricted immunity to Human Cytomegalovirus is directed against a variety of viral proteins, and modulated by its 84-87 DEAV/GGPM polymorphism (abstract) PRESENTER: Luisa Betke |
14:20 | T-cell receptor cross-reactivity against minor histocompatibility antigens and permissively mismatched HLA-DP reveals distinct features for DPB1*02:01 and *04:02 (abstract) PRESENTER: Esteban Arrieta-Bolaños |
14:30 | Towards the identification of hematopoietic tissue-specific T-cell receptors alloreactive to HLA-DPB1 (abstract) PRESENTER: Thuja Arrieta Bolaños |
14:40 | Cost-efficient targeted characterization of HLA and KIR haplotypes by Oxford Nanopore sequencing and its clinical potential (abstract) PRESENTER: Jesse Bruijnesteijn |
14:50 | Assessment of xenogeneic T-cell responses during ex vivo kidney perfusion (abstract) PRESENTER: Katharina Schmalkuche |
15:00 | Liquid biopsy for the detection of HLA-I alterations in cancer (abstract) PRESENTER: Alba Navarro Ocón |
15:10 | HLA-B*57:01 mediated abacavir susceptibility can be assigned to the upregulation of TCR Vβ24 and CD247 in drug responders (abstract) PRESENTER: Funmilola J Haukamp |
14:00-15:30 Session 11C: Abstract Session: Bioinformatics (O33-O40)
Chairs:
Location: Veilingzaal
14:00 | Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs (abstract) PRESENTER: Yoram Louzoun |
14:10 | Improving HLA imputation in admixed population with UMAP dimension reduction (abstract) PRESENTER: Nicolas Vince |
14:20 | Imputation of MHC class I non-classical HLA and non-HLA genes in the Finnish population (abstract) PRESENTER: Silja Tammi |
14:30 | The Role of HLA Epitope Mismatches in Antibody Development and Refractoriness to Optimize Allocation in Platelet Transfusion (abstract) PRESENTER: Benedict Matern |
14:40 | IPD-IMGT/HLA Database: updating the website with API functionality (abstract) PRESENTER: Dominic J. Barker |
14:50 | Allele imputation for the Killer cell Immunoglobulin-like Receptor KIR3DL1/S1 (abstract) PRESENTER: Paul Norman |
15:00 | C4Investigator, a high-throughput sequence analysis to identify novel variation in the complement component 4 (abstract) PRESENTER: Wesley Marin |
15:10 | Abacavir hypersensitivity beyond B*57:01; Prediction for new alleles (abstract) PRESENTER: Rosa Lammerts |
14:00-15:30 Session 11E: Special Session: Equality, Inclusiveness and Diversity
Chair:
Ann-Margaret Little (NHS, UK)
Location: Administratiezaal
14:00 | Equality, Inclusiveness and Diversity in Science |
14:30 | Equality, Inclusiveness and Diversity in Transplantation |
15:00 | Equality, Inclusiveness and Diversity within EFI |
16:00-17:30 Session 12A: Plenary session: Big data - Systems Biology
Chairs:
Frans Claas (LUMC, Netherlands)
Elissaveta Naumova (University Hospital Alexandrovska, Medical University, Sofia, Bulgaria)
Elissaveta Naumova (University Hospital Alexandrovska, Medical University, Sofia, Bulgaria)
Location: Effectenbeurszaal
16:00-17:30 Session 12B: Plenary session: Big data - Systems Biology (screened)
Location: Graanbeurszaal
Thursday, May 19th
View this program: with abstractssession overviewtalk overview
08:30-10:00 Session 14A: Plenary session: Tolerance Through Gene Therapy
Chairs:
Location: Effectenbeurszaal
08:30 | Innovative strategies for kidney bioengineering |
09:00 | Engineering cells (and organs) to evade immune detection |
09:30 | HLA-specific CAR Tregs in organ transplantation - from bench tot bedside |
08:30-10:00 Session 14B: Plenary session: Tolerance Through Gene Therapy (Screened)
Location: Graanbeurszaal
10:00-10:30Coffee Break
10:30-12:00 Session 16A: Special Session: Acceptable and Unacceptable Antigens in Solid Organ Transplantation
Chairs:
Location: Effectenbeurszaal
10:30-12:00 Session 16B: Teaching Session: Tissue-specific Immunity
Chairs:
Location: Graanbeurszaal
10:30 | Mucosal tolerance |
11:00 | Tolerance in kidney transplantation |
11:30 | Tolerance in stem cell transplantation |
10:30-12:00 Session 16C: Abstract Session: Stem Cell Transplantation (O41-O48)
Chairs:
Location: Veilingzaal
10:30 | High throughput sequencing monitoring of the T-cell receptor (TCR) repertoire after allogeneic hematopoietic stem cell transplantation, a six years follow-up: main influence of Cytomegalovirus in shaping the repertoire’s diversity and overlap (abstract) PRESENTER: Stephane Buhler |
10:40 | Stem cell donation probability by age, gender, CMV status and HLA genotype frequency (abstract) PRESENTER: Jürgen Sauter |
10:50 | CD147 expression and polymorphism as markers of cytomegalovirus infection in acute myeloid leukaemia patients following allogeneic stem cell transplantation (abstract) PRESENTER: Piotr Łacina |
11:00 | Matching beyond the HLA name: a new classification of HLA-allele mismatches based on peptide binding profile (abstract) PRESENTER: Kazutoyo Osoegawa |
11:10 | A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation (abstract) PRESENTER: Esteban Arrieta-Bolaños |
11:20 | CD4- and CD8-T cell receptor repertoires reconstitution after hematopoietic stem cell transplantation. (abstract) PRESENTER: Zuleika Calderin Sollet |
11:30 | Donor rs2204985 AA Genotype Associates with Worse Outcome after 9/10 HLA-matched Unrelated HSCT (abstract) PRESENTER: Chrysanthi Tsamadou |
11:40 | Permissiveness of HLA mismatch depends much on haplotype phase location of the mismatch (abstract) PRESENTER: Jacek Nowak |
10:30-12:00 Session 16D: Abstract Session: MHC and Anthropology (O49-O56)
Chairs:
Location: Administratiezaal
10:30 | The peptide editor HLA-DM modulates tumor associated antigen presentation by HLA-DP in the monocytic leukemia cell line THP-1 (abstract) PRESENTER: Pietro Crivello |
10:40 | Comparative analysis of human and chimpanzee full-length genomic Mhc class I A sequences revealed unreported signatures of evolutionary relationships (abstract) PRESENTER: Corrine Heijmans |
10:50 | Discovery of a MICA gene duplication with strong linkage to HLA-B*27:02 (abstract) PRESENTER: Anja Klussmeier |
11:00 | HLA global map: analysis of frequency variation in >200 populations reveals different patterns for class I and class II (abstract) PRESENTER: Esteban Arrieta-Bolaños |
11:10 | Human herpesvirus diversity is altered in HLA class I binding peptides (abstract) PRESENTER: William Palmer |
11:20 | Completing and Expanding the Human Genome Reference of the MHC (abstract) PRESENTER: Torsten Houwaart |
11:30 | A refined topography of the HLA molecular landscape across populations (abstract) PRESENTER: Alicia Sanchez-Mazas |
11:40 | Human and cynomolgus macaque Mhc-DQB transcripts may share alternative splice event skipping exon 4 encoding the transmembrane region (abstract) PRESENTER: Natasja G. de Groot |
12:00-13:00Lunch Break
13:00-13:45 Session 18A: Industry Sponsored Symposium: Oxford Nanopore Technologies
Location: Effectenbeurszaal
13:00-13:45 Session 18B: Industry Sponsored Symposium: One Lambda, Inc. A Thermo Fisher Scientific Brand
Location: Graanbeurszaal
14:00-15:30 Session 19A: Teaching Session: Bioinformatics
Chair:
Ben Matern (University Medical Center Utrecht, Netherlands)
Location: Effectenbeurszaal
14:00 | Developing bio informatics tools in NGS |
14:30 | NGS-based HLA typing in practice |
15:00 | TCR sequencing with NGS |
14:00-15:30 Session 19B: Abstract Session: Solid Organ Transplantation 2 (O57-O64)
Chairs:
Location: Graanbeurszaal
14:00 | Combined kidney and hematopoietic cell transplantation for tolerance induction between HLA matched sibling donor-recipient pairs (abstract) PRESENTER: Moshe Israeli |
14:10 | Single-cell sequence analyses of circulating T follicular helper cells during antibody-mediated rejection (abstract) PRESENTER: Emma Peereboom |
14:20 | Endothelial permeability to anti-HLA antibodies: towards new targets to prevent transplant vasculopathy (abstract) PRESENTER: Nicolas Congy-Jolivet |
14:30 | Site-directed mutagenesis of HLA molecules reveals the amino acids crucial for monoclonal antibody binding (abstract) PRESENTER: Tina Meng |
14:40 | Tacrolimus withdrawal after mesenchymal stromal cell therapy is associated with donor-specific antibody formation in kidney transplant recipients (abstract) PRESENTER: Suzanne Bezstarosti |
14:50 | The IgG panel from peripheral CD38+/138+ B cells represents a resilient surrogate marker for safe donor/recipient matching (abstract) PRESENTER: Christina Bade-Doeding |
15:00 | Genome-wide mismatch and deletion analysis in kidney transplantation (abstract) PRESENTER: Salla Markkinen |
15:10 | Association of SARS-CoV-2 vaccination with the development of anti-HLA antibodies in kidney transplant recipients (abstract) PRESENTER: Asimina Fylaktou |
14:00-15:30 Session 19C: Abstract Session: SARS-Cov-2 and miscellaneous (O65-O72)
Chairs:
Location: Administratiezaal
14:00 | HLA-ASSOCIATION STUDY WITH MORE THAN 16,000 PARTICIPANTS SHOWS NO HETEROZYGOTE ADVANTAGE FOR COVID-19 AND NO PROTECTIVE HLA-GENOTYPES (abstract) PRESENTER: Johannes Schetelig |
14:10 | MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population (abstract) PRESENTER: Yoram Louzoun |
14:20 | Results from the HLACOVID-ITALIA study: an unexpected correlation between HLA-DP antigen load and COVID-19 severity (abstract) PRESENTER: Pier Edoardo Rovatti |
14:30 | Polymorphism of the HLA system and weak antibody response to BNT162b2 mRNA vaccine (abstract) PRESENTER: Roberto Crocchiolo |
14:40 | Loss of tumor HLA class I and PD-L1 expression in bladder cancer is associated with higher tumor grade and poor survival prognosis (abstract) PRESENTER: Hernani Gil-Julio |
14:50 | HLA class II immune editing in JAK2V617 and CALR mutation driven oncogenesis (abstract) PRESENTER: Milena Ivanova |
15:00 | HLA-disease association and pleiotropy landscape in over 235 000 Finns (abstract) PRESENTER: Jukka Partanen |
15:10 | Functional impact of coding risk variant RUNX3 on brain-homing CD8+ T cells in multiple sclerosis (abstract) PRESENTER: Steven Koetzier |
14:00-15:30 Session 19D: Hands On Teaching Session: Case studies - Permissiveness of DSAs: to Transplant or Not?
Location: Berlagezaal
14:00 | Case studies on DSA |
14:22 | Case studies on DSA |
14:44 | Case studies on DSA |
15:06 | Case studies on DSA |
15:30-16:00Coffee Break
16:00-17:30 Session 21A: Plenary session: Future Perspectives in Stem Cell Transplantation
Chairs:
Location: Effectenbeurszaal
16:00-17:30 Session 21B: Plenary session: Future Perspectives in Stem Cell Transplantation (Screening)
Location: Graanbeurszaal
Friday, May 20th
View this program: with abstractssession overviewtalk overview
08:30-10:00 Session 23: Best Abstract Session (O1-O8)
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Luca Vago (IRCCS San Raffaele Scientific Institute, Italy)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Luca Vago (IRCCS San Raffaele Scientific Institute, Italy)
Location: Effectenbeurszaal
08:30 | One-Sided Chronic Intervillositis of Unknown Etiology in Dizygotic Twins display increased numbers of CD38+/HLA-DR+ macrophages in the affected twin. (abstract) PRESENTER: Juliette Krop |
08:40 | Engineered T cells overcoming rejection by antibodies (CORA-T cells) through selective targeting of alloreactive B cells in solid organ transplantation (abstract) PRESENTER: Anna Christina Dragon |
08:50 | HLA class II binding analysis for variants of SARS-CoV-2 Spike (abstract) PRESENTER: Hiroko Miyadera |
09:00 | Specific amino acids of HLA-DPB1 are strongly associated with Amyotrophic Lateral Sclerosis (abstract) PRESENTER: Danillo Augusto |
09:10 | Chimeric HLA-Antigen Receptor (CHAR) T-cell development – a new approach to target HLA sensitization (abstract) PRESENTER: Ilse Gille |
09:20 | Immunopeptidome divergence of HLA class I mismatches predicts survival after 9/10 matched unrelated stem cell transplantation (abstract) PRESENTER: Pietro Crivello |
09:30 | HLA haplotype frequency estimation for heterogeneous populations using a graph-based imputation algorithm (abstract) PRESENTER: Yoram Louzoun |
10:00-11:30 Session 24: Plenary session: State of the Art: COVID-19
Chairs:
Joannis Mytilineos (Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Germany)
John Trowsdale (Cambridge University, UK)
John Trowsdale (Cambridge University, UK)
Location: Effectenbeurszaal
10:00 | How the Sars-Cov2 pandemic unfolded |
10:30 | Immunogenetics and COVID-19 |
11:00 | Sars-Cov2 peptide presentation and immune response |
12:00-13:00 Session 25: Special Session: Reports From the 18th IHIWS
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Location: Effectenbeurszaal
13:00-14:30 Session 26: Closing Ceremony
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Ann-Margaret Little (NHS, UK)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Ann-Margaret Little (NHS, UK)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Location: Effectenbeurszaal
13:00 | Neuromagic |
13:45 | Jon van Rood Award and Best Abstract Awards |
14:00 | Best Poster Awards |
14:15 | Closing Remarks |