EFI2022: 35TH CONFERENCE OF THE EUROPEAN FEDERATION FOR IMMUNOGENETICS
PROGRAM

Days: Tuesday, May 17th Wednesday, May 18th Thursday, May 19th Friday, May 20th

Tuesday, May 17th

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13:00-14:00Lunch Break
17:30-19:00 Session 5A: Opening Ceremony
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
17:30
Eric Spierings (UMC Utrecht, Netherlands)
Welcome Address
17:40
Sebastiaan Heidt (LUMC, Netherlands)
Welcome Address
17:50
Welcome Address
18:00
Luca Vago (Ospedale San Raffaele, Italy)
Julia Bodmer Award
18:20
Steven Marsh (Anthony Nolan, UK)
HLA Award
18:30
Peter Doherty (University of Melbourne, Australia)
Ceppellini Lecture
Wednesday, May 18th

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08:30-10:00 Session 6A: Plenary session: Tolerance in Solid Organ Transplantation
Chairs:
Nils Lachmann (Charite, Germany)
Dave Roelen (LUMC, Netherlands)
08:30
Sophie Brouard (University of Nantes, France)
Microbiota and Immunoregulation: A focus on regulatory B Lymphocytes and transplantation
09:00
James Hutchinson (University Clinic Regensburg, Germany)
Regulatory macrophages in solid organ transplantation
09:30
Fadi Issa (Oxford University, UK)
The Two study: reducing immunosuppression in renal transplant recipients with the use of Tregs
10:00-10:30Coffee Break
10:30-12:00 Session 8A: Special Joint Session: EBMT and EFI
Chairs:
Harry Dolstra (Radboud University Medical Center, Netherlands)
Katharina Fleischhauer (University Hospital Essen, Germany)
10:30
Katharina Fleischhauer (University Hospital Essen, Germany)
Integrated HLA-DPB1 permissiveness models in stem cell transplantation
11:00
Benjamin Reuben (Kings College London, UK)
CAR-T cell therapy: allogeneic versus autologous
11:30
Harry Dolstra (Radboud UMC, Netherlands)
Allogeneic (CAR)NK-cell adoptive transfer
10:30-12:00 Session 8B: Teaching Session: Donor-specific HLA Antibodies - What Can Be Accepted?
Chairs:
Ann-Margaret Little (NHS, UK)
Stefan Schaub (University of Basel, Switzerland)
Malte Ziemann (University Hospital of Schleswig-Holstein, Germany)
Location: Graanbeurszaal
10:30
Stefan Schaub (University of Basel, Switzerland)
Methods for donor HLA antibody detection
11:00
Ann-Margaret Little (Scottish National Blood Transfusion Service, UK)
DSA: what is acceptable in stem cell transplantation?
11:30
Malte Ziemann (University Hospital of Schleswig-Holstein, Germany)
DSA: what is acceptable in solid organ transplantation?
10:30-12:00 Session 8C: Abstract Session: Solid Organ Transplantation 1 (O9-O16)
Chairs:
Gottfried Fischer (Medical University of Vienna, Austria)
Kirsten Geneugelijk (University Medical Center Utrecht, Netherlands)
Location: Veilingzaal
10:30
Uma Kanga (Dept of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India)
Akanksha Sharma (Dept of Transplant Immunology and Immunogenetics, AIIMS, New Delhi, India)
Sanjay Agarwal (Dept of Nephrology, AIIMS, New Delhi, India)
Prashanth Suravajhala (Amrita School of Biotechnology, Kerala, India)
Ajay Baranwal (Armed Forces Medical College, Pune, India)
Soumita Bagchi (Dept of Nephrology, AIIMS, New Delhi, India)
Gaurav Sharma (PGIMER, Chandigarh, India)
Molecular signatures for acute renal allograft rejection: long non coding RNAs as potential biomarkers (abstract)
PRESENTER: Uma Kanga
10:40
Burcu Duygu (MUMC+, Netherlands)
Mathijs Groeneweg (Maastricht University Medical Centre, Netherlands)
Bjorn Winkens (MUMC+, Netherlands)
Henny Otten (University Medical Center Utrecht, Netherlands)
Christina Voorter (MUMC+, Netherlands)
Lotte Wieten (MUMC+, Netherlands)
Effects of Natural Killer cell alloreactivity on allograft failure in kidney transplantation (abstract)
PRESENTER: Burcu Duygu
10:50
Suzanne Bezstarosti (Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Kim H. Bakker (Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Cynthia S. M. Kramer (Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Johan W. de Fijter (Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Marlies E. J. Reinders (Dept of Internal Medicine, Erasmus MC Transplantation Institute, University Medical Center Rotterdam, the Netherlands, Netherlands)
Arend Mulder (Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Frans H. J. Claas (Dept of Immunology, Leiden University Medical Center & Eurotransplant Reference Laboratory, Leiden, the Netherlands, Netherlands)
Sebastiaan Heidt (Dept of Immunology, Leiden University Medical Center & Eurotransplant Reference Laboratory, Leiden, the Netherlands, Netherlands)
A comprehensive evaluation of the antibody-verified status of eplets listed in the HLA Epitope Registry (abstract)
11:00
Franz Fenninger (University of British Columbia, Canada)
Vivian Wu (University of British Columbia, Canada)
Karen Sherwood (University of British Columbia, Canada)
Paul Keown (University of British Columbia, Canada)
Multi-Panel High-Dimensional Immunophenotyping of a Longitudinal Renal Transplant Cohort (abstract)
PRESENTER: Franz Fenninger
11:10
Melanie N Hug (University of Applied Sciences and Arts Northwestern Switzerland, Switzerland)
Sabrina Keller (University of Applied Sciences and Arts Northwestern Switzerland, Switzerland)
Talea Marty (University of Applied Sciences and Arts Northwestern Switzerland, Switzerland)
Daniel Gygax (University of Applied Sciences and Arts Northwestern Switzerland, Switzerland)
Dominik Meinel (University of Applied Sciences and Arts Northwestern Switzerland, Switzerland)
Peter Spiess (University of Applied Sciences and Arts Northwestern Switzerland, Switzerland)
Joelle Handschin (Transplantation Immunology, Department of Biomedicine, University of Basel, Switzerland)
Marc Kleiser (HLA-Diagnostics and Immunogenetics, Department of Laboratory Medicine, University Hospital Basel, Switzerland)
Noemi Vazquez (Transplantation Immunology, Department of Biomedicine, University of Basel, Switzerland)
Rico Buchli (PureProtein LLC., Oklahoma City, OK, United States)
Frans H.J. Claas (Department of Immunology, Leiden University Medical Center, Leiden, Netherlands)
Sebastiaan Heidt (Department of Immunology, Leiden University Medical Center, Leiden, Netherlands)
Jar-How Lee (Terasaki Innovation Center (TIC), Glendale, CA, United States)
Stefan Schaub (Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Switzerland)
Gideon Hoenger (Transplantation Immunology, Department of Biomedicine, University of Basel, Switzerland)
HLA antibody affinity assessment: from mAb to DSA (abstract)
PRESENTER: Gideon Hoenger
11:20
Aleksandar Senev (Senev Aleksandar, Belgium)
Bryan Ray (Immucor Inc, United States)
Jayasree Hariharan (Immucor Inc, United States)
Christine Heylen (Immucor Inc, Belgium)
Marie-Paule Emonds (KU Leuven, Belgium)
Maarten Naesens (KU Leuven, Belgium)
The pre-transplant non-HLA antibody burden predicts the development of histology of antibody-mediated rejection after kidney transplantation (abstract)
PRESENTER: Aleksandar Senev
11:30
Emma Peereboom (UMC Utrecht, Netherlands)
Ben Matern (UMC Utrecht, Netherlands)
Toshihide Tomosugi (Aichi Medical University School of Medicine, Japan)
Takaaki Kobayashi (Aichi Medical University School of Medicine, Japan)
Arjan van Zuilen (UMC Utrecht, Netherlands)
Kirsten Geneugelijk (UMC Utrecht, Netherlands)
Eric Spierings (UMC Utrecht, Netherlands)
T-cell epitopes shared between immunizing and donor HLA associate with kidney allograft failure (abstract)
PRESENTER: Emma Peereboom
11:40
Covadonga López del Moral (Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Germany., Spain)
Nils Lachmann (Institute for Transfusion Medicine, HLA-Laboratory, Charité - Universitätsmedizin Berlin, Germany, Germany)
Sabine Hergovits (Institute for Transfusion Medicine, HLA-Laboratory, Charité - Universitätsmedizin Berlin, Germany, Germany)
Diana Stauch (Institute for Transfusion Medicine, HLA-Laboratory, Charité - Universitätsmedizin Berlin, Germany, Germany)
Aylin Akifova (Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Germany, Germany)
Marcel Naik (Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Germany, Germany)
Bilgin Osmanodja (Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Germany, Germany)
Danilo Schmidt (Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Germany, Germany)
Klemens Budde (Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Germany, Germany)
Predictive value of the evolution of de novo DSA MFI values in kidney transplantation (abstract)
10:30-12:00 Session 8D: Abstract session: NK cells and Reproductive Immunology (O17-O24)

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Chairs:
John Trowsdale (Cambridge University, UK)
Lotte Wieten (Maastricht University Medical Center, Netherlands)
10:30
Laura Mora-Bitria (Imperial College London, UK)
Nicholas A. R. McQuibban (Imperial College London, UK)
Christoph Niederalt (Bayer AG, Germany)
Becca Asquith (Imperial College London, UK)
Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes (abstract)
10:40
Nanine de Groot (BPRC, Netherlands)
Annemiek de Vos-Rouweler (BPRC, Netherlands)
Natasja G. de Groot (BPRC, Netherlands)
Jesse Bruijnesteijn (BPRC, Netherlands)
Ronald E. Bontrop (BPRC, Netherlands)
Human group A and B KIR haplotypes are mirrored by inhibitory and activating KIR profiles in rhesus macaques (abstract)
PRESENTER: Nanine de Groot
10:50
Adèle Dhuyser (CHRU de Nancy, France)
Alice Aarnink (CHRU de Nancy, France)
Michaël Pérès (CHRU de Nancy, France)
Vitalina Chamberlain-Evans (University of Cambridge, UK)
Neda Nemat-Gorgani (University of Cambridge, UK)
Marie-Thérèse Rubio (CHRU de Nancy, France)
John Trowsdale (University of Cambridge, UK)
James Traherne (University of Cambridge, UK)
Application of the major predictive scoring strategies assessing KIR-based NK alloreactivity in donor/recipient couples (abstract)
PRESENTER: Adèle Dhuyser
11:00
Luciana De Brito Vargas (University of Colorado Anschutz Medical Campus, United States)
Katherine M. Kichula (University of Colorado Anschutz Medical Campus, United States)
Ticiana D. J. Farias (University of Colorado Anschutz Medical Campus, United States)
Paul J. Norman (University of Colorado Anschutz Medical Campus, United States)
Streamlining the discovery of new alleles for killer-cell Immunoglobulin-like receptor (KIR) genes (abstract)
11:10
Danillo Augusto (University of California, San Francisco, United States)
Wesley Marin (University of California, San Francisco, United States)
Jill Hollenbach (University of California, San Francisco, United States)
Beyond KIR: A novel next-generation sequencing method for the complete NK cell receptome (abstract)
PRESENTER: Danillo Augusto
11:20
Wesley Marin (University of California San Francisco, United States)
Jill Hollenbach (University of California San Francisco, United States)
Interpreting Killer-cell Immunoglobulin-like Receptor Whole Genome Sequence Data with PING (abstract)
PRESENTER: Wesley Marin
11:30
Juliette Krop (Leiden University Medical Center department of Immunology, Netherlands)
Anita van der Zwan (Leiden University Medical Center department of Immunology, Netherlands)
Marieke Ijsselsteijn (Leiden University Medical Center department of Pathology, Netherlands)
Hanneke Kapsenberg (Leiden University Medical Center department of Immunology, Netherlands)
Sietse Luk (Leiden University Medical Center department of Hematology, Netherlands)
Sanne Hendriks (Leiden University Medical Center department of Immunology, Netherlands)
Carin van der Keur (Leiden University Medical Center department of Immunology, Netherlands)
Lotte Verleng (Leiden University Medical Center department of Immunology, Netherlands)
Antonis Somarakis (Leiden University Medical Center department of Radiology, Netherlands)
Lotte van Meeren (Leiden University Medical Center department of Pathology, Netherlands)
Geert Haasnoot (Leiden University Medical Center department of Immunology, Netherlands)
Manon Bos (Leiden University Medical Center department of Pathology, Netherlands)
Noel de Miranda (Leiden University Medical Center department of Pathology, Netherlands)
Susana Chuva de Sousa Lopes (Leiden University Medical Center department of Embryology, Netherlands)
Marie-Louise van der Hoorn (Leiden University Medical Center department of Obstetrics, Netherlands)
Frits Koning (Leiden University Medical Center department of Immunology, Netherlands)
Frans H. J. Claas (Leiden University Medical Center department of Immunology, Netherlands)
Sebastiaan Heidt (Leiden University Medical Center department of Immunology, Netherlands)
Michael Eikmans (LUMC department of Immunology, Netherlands)
Visualizing the prevalence and interactions of maternal immune cells and fetal trophoblasts using imaging mass cytometry: the prominence of myeloid cells (abstract)
PRESENTER: Juliette Krop
11:40
Xuezi Tian (Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Natascha Goemaere (Department of Pathology, Maasstad Hospital, Rotterdam, the Netherlands, Netherlands)
Lotte van der Meeren (Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Michael Eikmans (Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Marie-Louise van der Hoorn (Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Inflammatory pathology lesions in the placenta are specifically observed in uncomplicated pregnancies after oocyte donation and are associated with fetal-maternal HLA mismatching (abstract)
PRESENTER: Xuezi Tian
10:30-12:00 Session 8E: Hands On Teaching Session: Bioinformatics - molecular Mismatch Tools in Practice
Chairs:
Ben Matern (University Medical Center Utrecht, Netherlands)
James Robinson (Anthony Nolan Research Institute, UK)
Location: Berlagezaal
10:30
Ben Matern (UMC Utrecht, Netherlands)
Case studies with PIRCHE and HLA-EMMA
11:00
Can Kesmir (Utrecht University, Netherlands)
Case studies with PIRCHE and HLA-EMMA
11:30
Cynthia Kramer (LUMC, Netherlands)
Case studies with PIRCHE and HLA-EMMA
12:00-13:00Lunch Break
14:00-15:30 Session 11A: Teaching Session: Non-HLA Antibodies: How Permissible Are They in Transplant Settings?
Chair:
Henny Otten (UMC Utrecht, Netherlands)
14:00
Henny Otten (UMC Utrecht, Netherlands)
Non-HLA antibodies: acquirement and detection
14:30
Maarten Naesens (University Hospital Leuven, Belgium)
Clinical relevance for kidney transplantation: are non-HLA antibodies acceptable?
15:00
Stefan Berger (UMC Groningen, Netherlands)
Permissiveness of non-HLA antibodies in different transplantation settings
14:00-15:30 Session 11B: Abstract Session: Immunotherapy, Gene Therapy and New Technologies (O25-O32)
Chairs:
Rainer Blasczyk (Hannover Medical School, Germany)
Neema Mayor (Anthony Nolan, UK)
Location: Graanbeurszaal
14:00
Nicky Beelen (Maastricht University, Netherlands)
Merel Aberle (Maastricht University, Netherlands)
Virginia Bruno (Maastricht University, Netherlands)
Steven Olde Damink (Maastricht University, Netherlands)
Gerard Bos (Maastricht University Medical Center, Netherlands)
Sander Rensen (Maastricht University, Netherlands)
Lotte Wieten (Maastricht University Medical Center, Netherlands)
Patient-derived 3D-organoids to study combination therapies of NK cells and antibody-dependent cellular cytotoxicity-inducing antibodies in pancreatic cancer (abstract)
PRESENTER: Nicky Beelen
14:10
Luisa Betke (University Hospital Essen, Institute for Experimental Cellular Therapy, Germany)
Pietro Crivello (University Hospital Essen, Institute for Experimental Cellular Therapy, Germany)
Fabienne Maassen (University Hospital Essen, Institute for Experimental Cellular Therapy; Institute for Virology, Germany)
Corinna Schuler (University Hospital Essen, Institute for Virology, Germany)
Thuja Arrieta-Bolanos (University Hospital Essen, Institute for Experimental Cellular Therapy, Germany)
Esteban Arrieta-Bolanos (University Hospital Essen, Institute for Experimental Cellular Therapy, Germany)
Lars Dölken (Maximilians-University Würzburg, Institute for Virology and Immunobiology, Germany)
Florian Erhard (Maximilians-University Würzburg, Institute for Virology and Immunobiology, Germany)
Mirko Trilling (University Hospital Essen, Institute for Virology, Germany)
Katharina Fleischhauer (University Hospital Essen, Institute for Experimental Cellular Therapy; German Cancer Consortium (DKTK), Germany)
HLA-DP-restricted immunity to Human Cytomegalovirus is directed against a variety of viral proteins, and modulated by its 84-87 DEAV/GGPM polymorphism (abstract)
PRESENTER: Luisa Betke
14:20
Marina Eleftheriou (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Kulvara Kittisares (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Thorben Walther (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Luisa Betke (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Marieke Griffioen (Department of Hematology, Leiden University Medical Center, Netherlands)
Peter A. Horn (Institute for Transfusion Medicine, University Hospital Essen, Germany)
J.H. Frederik Falkenburg (Department of Hematology, Leiden University Medical Center, Netherlands)
Katharina Fleischhauer (Institute for Experimental Cellular Therapy, University Hospital Essen & German Cancer Consortium (DKTK), Germany)
Esteban Arrieta-Bolaños (Institute for Experimental Cellular Therapy, University Hospital Essen & German Cancer Consortium (DKTK), Germany)
T-cell receptor cross-reactivity against minor histocompatibility antigens and permissively mismatched HLA-DP reveals distinct features for DPB1*02:01 and *04:02 (abstract)
14:30
Thuja Arrieta Bolaños (Institute for Experimental Cellular Therapy, Germany)
Pietro Crivello (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany, Germany)
Theresa Pietz (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany, Germany)
Monika Lindemann (Institute for Transfusion Medicine, University Hospital Essen, Germany, Germany)
Peter A. Horn (Institute for Transfusion Medicine, University Hospital Essen, Germany, Germany)
J.H. Frederik Falkenburg (Laboratory of Experimental Haematology, Leiden University Medical Center, Leiden, The Netherlands, Germany)
Esteban Arrieta Bolaños (Institute for Experimental Cellular Therapy, University Hospital Essen and German Cancer Consortium (DKTK), Germany, Germany)
Katharina Fleischhauer (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany, Germany)
Towards the identification of hematopoietic tissue-specific T-cell receptors alloreactive to HLA-DPB1 (abstract)
14:40
Jesse Bruijnesteijn (Biomedical Primate Research Centre, Netherlands)
Marit van der Wiel (Biomedical Primate Research Centre, Netherlands)
Nanine de Groot (Biomedical Primate Research Centre, Netherlands)
Ronald Bontrop (Biomedical Primate Research Centre, Netherlands)
Cost-efficient targeted characterization of HLA and KIR haplotypes by Oxford Nanopore sequencing and its clinical potential (abstract)
14:50
Katharina Schmalkuche (Hannover Medical School, Germany)
Tamina Rother (Hannover Medical School, Germany)
Yuliia Yuzefovych (Hannover Medical School, Germany)
Nadine Wenzel (Hannover Medical School, Germany)
Rainer Blasczyk (Hannover Medical School, Germany)
Constanca Figueiredo (Hannover Medical School, Germany)
Assessment of xenogeneic T-cell responses during ex vivo kidney perfusion (abstract)
15:00
Alba Navarro Ocón (University of Granada, Spain)
Laura Cabo Zabala (University Hospital "Virgen de las Nieves", Spain)
Berit Brinkmann (University of Duisburg-Essen, Germany)
Alberto López Sánchez (University of Granada, Spain)
Annette Paschen (University Hospital Essen, Germany)
Federico Garrido (University Hospital "Virgen de las Nieves" and University of Granada, Spain)
Francisco Ruiz Cabello (University Hospital "Virgen de las Nieves" and University of Granada, Spain)
Natalia Aptsiauri (University of Granada, Spain)
Liquid biopsy for the detection of HLA-I alterations in cancer (abstract)
15:10
Funmilola J Haukamp (Hanover Medical School, Germany)
Eline Gall (Hanover Medical School, Germany)
Florian Stieglitz (Hanover Medical School, Germany)
Andreas Pich (Hanover Medical School, Germany)
Georg M. N. Behrens (Hanover Medical School, Germany)
Joachim Kuhn (Hanover Medical School, Germany)
Rainer Blasczyk (Hanover Medical School, Germany)
Christina Bade-Doeding (Hanover Medical School, Germany)
HLA-B*57:01 mediated abacavir susceptibility can be assigned to the upregulation of TCR Vβ24 and CD247 in drug responders (abstract)
14:00-15:30 Session 11C: Abstract Session: Bioinformatics (O33-O40)
Chairs:
Martin Maiers (NMDP, United States)
Nicolas Vince (University of Nantes, France)
Location: Veilingzaal
14:00
Ido Springer (Bar Ilan Univesity, Israel)
Yoram Louzoun (Bar Ilan University, Israel)
Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs (abstract)
PRESENTER: Yoram Louzoun
14:10
Venceslas Douillard (CR2TI, France)
Nayane S. B. Silva (São Paulo State University, Brazil)
Sophie Limou (CR2TI, France)
Pierre-Antoine Gourraud (CR2TI, France)
Erick C. Castelli (São Paulo State University, Brazil)
Nicolas Vince (CR2TI, France)
Improving HLA imputation in admixed population with UMAP dimension reduction (abstract)
PRESENTER: Nicolas Vince
14:20
Silja Tammi (Finnish Red Cross Blood Service, Finland)
Satu Koskela (Finnish Red Cross Blood Service, Finland)
Kati Hyvärinen (Finnish Red Cross Blood Service, Finland)
Jukka Partanen (Finnish Red Cross Blood Service, Finland)
Jarmo Ritari (Finnish Red Cross Blood Service, Finland)
Imputation of MHC class I non-classical HLA and non-HLA genes in the Finnish population (abstract)
PRESENTER: Silja Tammi
14:30
Benedict Matern (University Medical Center Utrecht, Netherlands)
Johanna Walther (Utrecht University, Netherlands)
Emma Peereboom (University Medical Center Utrecht, Netherlands)
Kirsten Geneugelijk (University Medical Center Utrecht, Netherlands)
Can Keşmir (Utrecht University, Netherlands)
Eric Spierings (University Medical Center Utrecht, Netherlands)
The Role of HLA Epitope Mismatches in Antibody Development and Refractoriness to Optimize Allocation in Platelet Transfusion (abstract)
PRESENTER: Benedict Matern
14:40
Dominic J. Barker (Anthony Nolan Research Institute, UK)
Xenia Georgiou (Anthony Nolan Research Institute, UK)
Michael A. Cooper (Anthony Nolan Research Institute, UK)
Giuseppe Maccari (Anthony Nolan Research Institute, UK)
James Robinson (Anthony Nolan Research Institute and UCL Cancer Institute, UK)
Steven G.E. Marsh (Anthony Nolan Research Institute and UCL Cancer Institute, UK)
IPD-IMGT/HLA Database: updating the website with API functionality (abstract)
14:50
Genelle Harrison (University of Colorado Anschutz Medical Campus, United States)
Laura Ann Leaton (University of Colorado Anschutz Medical Campus, United States)
Katherine Kichula (University of Colorado Anschutz Medical Campus, United States)
Erica Harrison (University of Colorado Anschutz Medical Campus, United States)
Paul Norman (University of Colorado Anschutz Medical Campus, United States)
Allele imputation for the Killer cell Immunoglobulin-like Receptor KIR3DL1/S1 (abstract)
PRESENTER: Paul Norman
15:00
Wesley Marin (University of California San Francisco, United States)
Danillo Augusto (University of California San Francisco, United States)
Jill Hollenbach (University of California San Francisco, United States)
C4Investigator, a high-throughput sequence analysis to identify novel variation in the complement component 4 (abstract)
PRESENTER: Wesley Marin
15:10
Rosa Lammerts (University Medical Center Groningen, Netherlands)
Julian Vivian (Monash University, Clayton, VIC, Australia, Australia)
Patricia Illing (Monash University, Clayton, VIC, Australia, Australia)
Niels Kouprie (University medical center Groningen, Netherlands)
Laura Bungener (University medical center Groningen, Netherlands)
Bouke Hepkema (University medical center Groningen, Netherlands)
Abacavir hypersensitivity beyond B*57:01; Prediction for new alleles (abstract)
PRESENTER: Rosa Lammerts
14:00-15:30 Session 11E: Special Session: Equality, Inclusiveness and Diversity
Chair:
14:00
Equality, Inclusiveness and Diversity in Science
14:30
Alicia Venter (WMDA, Netherlands)
Equality, Inclusiveness and Diversity in Transplantation
15:00
Gisela van der Velden (UMC Utrecht, Netherlands)
Equality, Inclusiveness and Diversity within EFI
16:00-17:30 Session 12A: Plenary session: Big data - Systems Biology
Chairs:
Frans Claas (LUMC, Netherlands)
Elissaveta Naumova (University Hospital Alexandrovska, Medical University, Sofia, Bulgaria)
16:00
Menna Clatworthy (Cambridge University, UK)
Cell atlas methods to study tissue-resident immunity
16:30
Lluis Quintana-Murci (Institut Pasteur, France)
Human immunology through the Lens of evolutionary genetics
17:00
Vincent van Unen (Stanford, United States)
Computational approaches and air-liquid interface organoids to study immune-mediated human disorders
Thursday, May 19th

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08:30-10:00 Session 14A: Plenary session: Tolerance Through Gene Therapy
Chairs:
Mats Bengtsson (Uppsala University Hospital, Sweden)
Antonij Slavčev (IKEM, Czechia)
08:30
Ton Rabelink (LUMC, Netherlands)
Innovative strategies for kidney bioengineering
09:00
Rainer Blasczyk (Hannover Medical School, Germany)
Engineering cells (and organs) to evade immune detection
09:30
Megan Levings (BC Children's Hospital Research Institute, Canada)
HLA-specific CAR Tregs in organ transplantation - from bench tot bedside
10:00-10:30Coffee Break
10:30-12:00 Session 16A: Special Session: Acceptable and Unacceptable Antigens in Solid Organ Transplantation
Chairs:
Bouke Hepkema (UMCG, Netherlands)
Jean Villard (Université de Genève, Switzerland)
10:30
Stefan Schaub (University of Basel, Switzerland)
Solid phase assays to determine HLA antibodies: pros and cons
11:00
David Turner (Scottish National Blood Transfusion Service, UK)
Utility of the virtual crossmatch in kidney transplantation
11:30
Nils Lachmann (Charite, Germany)
Modes of identifying acceptable vs non-acceptable mismatches in kidney transplantation
10:30-12:00 Session 16B: Teaching Session: Tissue-specific Immunity
Chairs:
Michael Eikmans (LUMC, Netherlands)
Arnold van der Meer (Radboud UMC, Netherlands)
Location: Graanbeurszaal
10:30
Janneke Samson (Erasmus MC, Netherlands)
Mucosal tolerance
11:00
Raphael Duivenvoorden (Radboud UMC, Netherlands)
Tolerance in kidney transplantation
11:30
Femke van Wijke (UMC Utrecht, Netherlands)
Tolerance in stem cell transplantation
10:30-12:00 Session 16C: Abstract Session: Stem Cell Transplantation (O41-O48)
Chairs:
Marco Andreani (Ospedale Pediatrico Bambino Gesu, Italy)
Laura Bungener (UMCG, Netherlands)
Location: Veilingzaal
10:30
Stephane Buhler (Geneva University Hospitals, Switzerland)
Zuleika Calderin Sollet (Geneva University Hospitals, Switzerland)
Antonia Schaefer (Geneva University Hospitals, Switzerland)
Florence Bettens (Geneva University Hospitals, Switzerland)
Carole Dantin (Geneva University Hospitals, Switzerland)
Sylvie Ferrari-Lacraz (Geneva University Hospitals, Switzerland)
Marc Ansari (Geneva University Hospitals, Switzerland)
Anne-Claire Mamez (Geneva University Hospitals, Switzerland)
Stavroula Masouridi-Levrat (Geneva University Hospitals, Switzerland)
Yves Chalandon (Geneva University Hospitals, Switzerland)
Jean Villard (Geneva University Hospitals, Switzerland)
High throughput sequencing monitoring of the T-cell receptor (TCR) repertoire after allogeneic hematopoietic stem cell transplantation, a six years follow-up: main influence of Cytomegalovirus in shaping the repertoire’s diversity and overlap (abstract)
PRESENTER: Stephane Buhler
10:40
Jürgen Sauter (DKMS, Germany)
Daniel Schefzyk (DKMS, Germany)
Jan A. Hofmann (DKMS, Germany)
Jens Pruschke (DKMS, Germany)
Thilo Mengling (DKMS, Germany)
Alexander H. Schmidt (DKMS, Germany)
Stem cell donation probability by age, gender, CMV status and HLA genotype frequency (abstract)
PRESENTER: Jürgen Sauter
10:50
Piotr Łacina (Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland, Poland)
Jagoda Siemaszko (Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland, Poland)
Anna Czyż (Wroclaw Medical University, Wrocław, Poland, Poland)
Agnieszka Szeremet (Wroclaw Medical University, Wrocław, Poland, Poland)
Maciej Majcherek (Wroclaw Medical University, Wrocław, Poland, Poland)
Wojciech Fidyk (Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Gliwice, Poland, Poland)
Małgorzata Sobczyk-Kruszelnicka (Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Gliwice, Poland, Poland)
Sebastian Giebel (Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Gliwice, Poland, Poland)
Barbara Nasiłowska-Adamska (Institute of Hematology and Blood Transfusion, Warsaw, Poland, Poland)
Iwona Solarska (Institute of Hematology and Blood Transfusion, Warsaw, Poland, Poland)
Agnieszka Tomaszewska (Medical University of Warsaw, Warsaw, Poland, Poland)
Grzegorz W. Basak (Medical University of Warsaw, Warsaw, Poland, Poland)
Tomasz Wróbel (Wroclaw Medical University, Wrocław, Poland, Poland)
Katarzyna Bogunia-Kubik (Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland, Poland)
CD147 expression and polymorphism as markers of cytomegalovirus infection in acute myeloid leukaemia patients following allogeneic stem cell transplantation (abstract)
PRESENTER: Piotr Łacina
11:00
Kazutoyo Osoegawa (Histocompatibility & Immunogenetics Laboratory, Stanford Blood Center, United States)
Kristen Cunanan (Quantitative Sciences Unit, Stanford University School of Medicine, United States)
Stephen Spellman (Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, United States)
Alice Bertaina (Department of Pediatrics, Stanford University School of Medicine, United States)
Marcelo A. Fernández-Viña (Department of Pathology, Stanford University School of Medicine, United States)
Matching beyond the HLA name: a new classification of HLA-allele mismatches based on peptide binding profile (abstract)
11:10
Esteban Arrieta-Bolaños (Institute for Experimental Cellular Therapy, University Hospital Essen & German Cancer Consortium (DKTK), Germany)
Pietro Crivello (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Meilun He (CIBMTR, NMDP/Be The Match, United States)
Tao Wang (CIBMTR, NMDP/Be The Match & Division of Biostatistics, Medical College of Wisconsin, United States)
Shahinaz Gadalla (Division of Cancer Epidemiology and Genetics, National Cancer Institute, United States)
Sophie Paczesny (Medical University of South Carolina, United States)
Steven G. E. Marsh (Anthony Nolan Research Institute & Cancer Institute, University College London, UK)
Stephanie J. Lee (CIBMTR, NMDP/Be The Match & Fred Hutchinson Cancer Research Center, United States)
Stephen R. Spellman (CIBMTR, NMDP/Be The Match, United States)
Yung-Tsi Bolon (CIBMTR, NMDP/Be The Match, United States)
Katharina Fleischhauer (Institute for Experimental Cellular Therapy, University Hospital Essen & German Cancer Consortium (DKTK), Germany)
A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation (abstract)
11:20
Zuleika Calderin Sollet (1Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Geneva University Hospitals, Switzerland)
Stephane Buhler (1Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Geneva University Hospitals, Switzerland)
Antonia Schäfer (1Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Geneva University Hospitals, Switzerland)
Sylvie Ferrari-Lacraz (1Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Geneva University Hospitals, Switzerland)
Stavroula Masouridi-Levrat (2Service of Haematology, Department of Oncology, Geneva University Hospitals, Switzerland)
Anne-Claire Mamez (2Service of Haematology, Department of Oncology, Geneva University Hospitals, Switzerland)
Yves Chalandon (2Service of Haematology, Department of Oncology, Geneva University Hospitals, Switzerland)
Jean Villard (1Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Geneva University Hospitals, Switzerland)
CD4- and CD8-T cell receptor repertoires reconstitution after hematopoietic stem cell transplantation. (abstract)
11:30
Chrysanthi Tsamadou (Institute of Clinical Transfusion Medicine and Immunogenetics Ulm and University Hospital Ulm, Germany)
Uwe Platzbecker (Department of Hematology/Oncology, University of Leipzig, Germany)
Elisa Sala (Department of Internal Medicine III, University of Ulm, Germany)
Thomas Valerius (Division of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine, University of Kiel, Germany)
Eva Wagner-Drouet (Department of Medicine III, Johannes Gutenberg-University Mainz, Germany)
Gerald Wulf (Department of Hematology/Oncology, Georg-August-University Göttingen, Germany)
Nicolaus Kröger (Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Germany)
Niels Murawski (Department Internal Medicine I, Universitätsklinikum des Saarlandes, Homburg, Germany)
Hermann Einsele (Department of Internal Medicine II, University Hospital Würzburg, Germany)
Kerstin Schaefer-Eckart (Medical Clinic 5: Hematology, Oncology, Nuremberg Hospital, Germany)
Sebastian Freitag (Department of Medicine III, Hematology/Oncology/Palliative Care, Rostock University Medical Center, Rostock, Germany)
Jochen Casper (Department of Oncology and Hematology, Klinikum Oldenburg, University Clinic, Oldenburg, Germany)
Martin Kaufmann (2nd Department of Internal Medicine, Oncology and Hematology, Robert Bosch Hospital Stuttgart, Germany)
Mareike Dürholt (Hematology/Oncology, Evangelic Clinic Essen-Werden, Germany)
Bernd Hertenstein (Hematology/Oncology, Klinikum Bremen-Mitte, Bremen, Germany)
Stefan Klein (Universitätsmedizin Mannheim, Med. Klinik III, Mannheim, Germany)
Mark Ringhoffer (Medizinische Klinik III, Städtisches Klinikum Karlsruhe, Germany)
Sowmya Gowdavally (Medical Faculty University of Ulm, Germany)
Christine Neuchel (Institute of Clinical Transfusion Medicine and Immunogenetics Ulm and University Hospital Ulm, Germany)
Immanuel Rode (Institute of Clinical Transfusion Medicine and Immunogenetics Ulm and University Hospital Ulm, Germany)
Joannis Mytilineos (ZKRD - Zentrales Knochenmarkspender-Register für Deutschland, German National Bone Marrow Donor Registry, Germany)
Hubert Schrezenmeier (Institute of Clinical Transfusion Medicine and Immunogenetics Ulm and University Hospital Ulm, Germany)
Daniel Fürst (Institute of Clinical Transfusion Medicine and Immunogenetics Ulm and University Hospital Ulm, Germany)
Donor rs2204985 AA Genotype Associates with Worse Outcome after 9/10 HLA-matched Unrelated HSCT (abstract)
11:40
Jacek Nowak (Institute of Hematology and Transfusion Medicine, Poland)
Agnieszka Witkowska (Institute of Hematology and Transfusion Medicine, Poland)
Urszula Szlendak (Institute of Hematology and Transfusion Medicine, Poland)
Agnieszka Malinowska (Institute of Hematology and Transfusion Medicine, Poland)
Marta Rogatko-Koroś (Institute of Hematology and Transfusion Medicine, Poland)
Elżbieta Graczyk-Pol (Institute of Hematology and Transfusion Medicine, Poland)
Beata Kaczmarek (Institute of Hematology and Transfusion Medicine, Poland)
Anna Flaga (Institute of Hematology and Transfusion Medicine, Poland)
Agnieszka Gawron (Institute of Hematology and Transfusion Medicine, Poland)
Permissiveness of HLA mismatch depends much on haplotype phase location of the mismatch (abstract)
PRESENTER: Jacek Nowak
10:30-12:00 Session 16D: Abstract Session: MHC and Anthropology (O49-O56)
Chairs:
Jose Manuel De Abreu Nunes (University of Geneva, Switzerland)
Natasja de Groot (BPRC, Netherlands)
10:30
Pietro Crivello (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Thilo Bracht (Medical Proteome Center, Center for Protein Diagnostics, Ruhr University Bochum, Germany)
Sophia Layer (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Joana Peters (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Barbara Sitek (Medical Proteome Center, Center for Protein Diagnostics, Ruhr University Bochum, Germany)
Katharina Fleischhauer (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
The peptide editor HLA-DM modulates tumor associated antigen presentation by HLA-DP in the monocytic leukemia cell line THP-1 (abstract)
PRESENTER: Pietro Crivello
10:40
Corrine Heijmans (Biomedical Primate Research Centre, Netherlands)
Ronald E. Bontrop (Biomedical Primate Research Centre, Netherlands)
Alicia Sanchez-Mazas (University of Geneva, Switzerland)
Natasja G. de Groot (Biomedical Primate Research Centre, Netherlands)
Comparative analysis of human and chimpanzee full-length genomic Mhc class I A sequences revealed unreported signatures of evolutionary relationships (abstract)
PRESENTER: Corrine Heijmans
10:50
Anja Klussmeier (DKMS Life Science Lab, Dresden, Germany, Germany)
Carolin Massalski (DKMS Life Science Lab, Dresden, Germany, Germany)
Daniel Schefzyk (DKMS, Tübingen, Germany, Germany)
Gesine Schäfer (DKMS Life Science Lab, Dresden, Germany, Germany)
Jürgen Sauter (DKMS, Tübingen, Germany, Germany)
Alexander H. Schmidt (DKMS, Tübingen, Germany; DKMS Life Science Lab, Dresden, Germany, Germany)
Vinzenz Lange (DKMS Life Science Lab, Dresden, Germany, Germany)
Discovery of a MICA gene duplication with strong linkage to HLA-B*27:02 (abstract)
PRESENTER: Anja Klussmeier
11:00
Esteban Arrieta-Bolaños (Institute for Experimental Cellular Therapy, University Hospital Essen & German Cancer Consortium (DKTK), Germany)
Diana Iraíz Hernández-Zaragoza (Laboratorio de Genética Molecular, Escuela Nacional de Antropología e Historia (ENAH), Mexico)
Rodrigo Barquera (Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology (MPI-EVA), Germany)
HLA global map: analysis of frequency variation in >200 populations reveals different patterns for class I and class II (abstract)
11:10
William Palmer (University of Colorado, United States)
Marco Telford (Universitat Pompeu Fabra, Spain)
Arcadi Navarro (Universitat Pompeu Fabra, Spain)
Gabriel Santpere (Universitat Pompeu Fabra, Spain)
Paul Norman (University of Colorado, United States)
Human herpesvirus diversity is altered in HLA class I binding peptides (abstract)
PRESENTER: William Palmer
11:20
Torsten Houwaart (Heinrich Heine University Düsseldorf, Germany)
Nicholas R. Pollock (University of Colorado Anschutz Medical Campus, United States)
Stephan Scholz (Heinrich Heine University Düsseldorf, Germany)
Katherine M. Kichula (University of Colorado Anschutz Medical Campus, United States)
William H. Palmer (University of Colorado Anschutz Medical Campus, United States)
Ticiana Dj Farias (University of Colorado Anschutz Medical Campus, United States)
Peter Parham (Stanford University, United States)
Lisbeth A. Guethlein (Stanford University, United States)
Alexander Dilthey (Heinrich Heine University Düsseldorf, Germany)
Paul J. Norman (University of Colorado Anschutz Medical Campus, United States)
Completing and Expanding the Human Genome Reference of the MHC (abstract)
PRESENTER: Torsten Houwaart
11:30
José Manuel Nunes (Laboratory of Anthropology, Genetics and Peopling history, University of Geneva, Geneva, Switzerland)
Da Di (Laboratory of Anthropology, Genetics and Peopling history, University of Geneva, Geneva, Switzerland)
Pascale Gerbault (Laboratory of Anthropology, Genetics and Peopling history, University of Geneva, Geneva, Switzerland)
Ndeye K. Faye (Laboratory of Anthropology, Genetics and Peopling history, University of Geneva, Geneva, Switzerland)
Wassim Almawi (Nazarbayev University School of Medicine, Nur-Sultan, Kazakhstan)
Marco Andreani (IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy)
Esteban Arrieta-Bolanos (University Hospital Essen, Germany)
Roberto Díaz Peña (Universidad Autónoma de Chile, Talca, Chile)
Selma D'Silva (Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Mumbai, India)
Valérie Dubois (EFS Auvergne Rhone Alpes, Décines-Charpieu, France)
Gehad Eltayeb Elghazali (Sheikh Khalifa Medical City, Abu Dhabi, UAE)
Clara Gorodezky (Laboratorios de Immunología e Immunogenética de la Fundacion Comparte Vida, Mexico City, Mexico)
Zorana Grubić (University Hospital Centre Zagreb, Zagreb, Croatia)
Ali Hajeer (King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia)
Milena Ivanova (University Hospital Alexandrovska, Sofia, Bulgaria)
Aashish Jha (New York University Abu Dhabi (NYUAD), UAE)
Uma Kanga (All India Institute of Medical Sciences, New Dehli, India)
Meri Kirijas (Biomedica dijagnostika, Skopje, Macedonia)
William Lemieux (Héma-Québec, Saint-Laurent, Québec, Canada)
Tobias Lenz (University of Hamburg, Hamburg, Germany)
Maria Loginova (Kirov Scientific-research Institute of Hematology and Blood Transfusion of FMBA of Russia, Kirov, Russia)
Nadia Mahfoudh (Faculty of Medicine of Sfax, Sfax, Tunisia)
Narinder Mehra (All India Institute of Medical Sciences, New Dehli, India)
Martin Petrek (Palacky University Olomouc, Olomouc, Czechia)
Lucie Richard (Héma-Québec, Saint-Laurent, Québec, Canada)
Dave L. Roelen (Leiden University Medical Center, Leiden, Netherlands)
Nicoletta Sacchi (E. O. Ospedali Galliera, Genova, Italy)
Bisu Singh (Sikkim University, Gangtok, India)
Meenakshi Singh (Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Mumbai, India)
Katerina Tarassi (Evangelismos Hospital, Athens, Greece)
Christelle Vangenot (Laboratory of Anthropology, Genetics and Peopling history, University of Geneva, Geneva, Switzerland)
Blanka Vidan-Jeras (Blood Transfusion Center of Slovenia, Ljubljana, Slovenia)
Linda Vigilant (Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany)
Emily Wroblewski (Washington University, St Louis, United States)
Stéphane Buhler (National Reference Laboratory for Histocompatibility (LNRH), Geneva University Hospital, Geneva, Switzerland)
Jean Villard (National Reference Laboratory for Histocompatibility (LNRH), Geneva University Hospital, Geneva, Switzerland)
Natasja De Groot (BPRC, Rijswijk, Netherlands)
Alicia Sanchez-Mazas (Laboratory of Anthropology, Genetics and Peopling history, University of Geneva, Geneva, Switzerland)
A refined topography of the HLA molecular landscape across populations (abstract)
11:40
Natasja G. de Groot (Biomedical Primate Research Centre, Netherlands)
Nanine de Groot (Biomedical Primate Research Centre, Netherlands)
Annemiek J.M. de Vos-Rouweler (Biomedical Primate Research Centre, Netherlands)
Jesse Bruijnesteijn (Biomedical Primate Research Centre, Netherlands)
Ronald E. Bontrop (Biomedical Primate Research Centre, Netherlands)
Human and cynomolgus macaque Mhc-DQB transcripts may share alternative splice event skipping exon 4 encoding the transmembrane region (abstract)
12:00-13:00Lunch Break
14:00-15:30 Session 19A: Teaching Session: Bioinformatics
Chair:
Ben Matern (University Medical Center Utrecht, Netherlands)
14:00
Gerhard Schöfl (DKMS, Germany)
Developing bio informatics tools in NGS
14:30
Neema Mayor (Anthony Nolan, UK)
NGS-based HLA typing in practice
15:00
Peter de Greef (Utrecht University, Netherlands)
TCR sequencing with NGS
14:00-15:30 Session 19B: Abstract Session: Solid Organ Transplantation 2 (O57-O64)
Chairs:
Wendy Swelsen (Sanquin, Netherlands)
David Turner (SNBTS, UK)
Location: Graanbeurszaal
14:00
Moshe Israeli (Rabin Medical Center, Israel)
Eviatar Nesher (Rabin Medical Center, Israel)
Ruth Rahamimov (Rabin Medical Center, Israel)
Liat Shargian (Rabin Medical Center, Israel)
Oren Pasvolsky (Rabin Medical Center, Israel)
Eyal Fenig (Rabin Medical Center, Israel)
Eytan Mor (Rabin Medical Center, Israel)
Moshe Yeshurun (Rabin Medical Center, Israel)
Combined kidney and hematopoietic cell transplantation for tolerance induction between HLA matched sibling donor-recipient pairs (abstract)
PRESENTER: Moshe Israeli
14:10
Emma Peereboom (UMC Utrecht, Netherlands)
Kirsten Geneugelijk (UMC Utrecht, Netherlands)
Karin Boer (Erasmus MC, Netherlands)
Carla Baan (Erasmus MC, Netherlands)
Eric Spierings (UMC Utrecht, Netherlands)
Single-cell sequence analyses of circulating T follicular helper cells during antibody-mediated rejection (abstract)
PRESENTER: Emma Peereboom
14:20
Ophélie Ferrary (INSERM/UPS UMR 1297 I2MC, Toulouse, France, France)
Audrey Swiader (INSERM/UPS UMR 1297 I2MC, Toulouse, France, France)
Natalia Smirnova (INSERM/UPS UMR 1297 I2MC, Toulouse, France, France)
Muriel Laffargue (INSERM/UPS UMR 1297 I2MC, Toulouse, France, France)
Anne Negre-Salvayre (INSERM/UPS UMR 1297 I2MC, Toulouse, France, France)
Nicolas Congy-Jolivet (INSERM/UPS UMR 1037 Team 20; HLA laboratory, Toulouse hospital, France., France)
Endothelial permeability to anti-HLA antibodies: towards new targets to prevent transplant vasculopathy (abstract)
14:30
Tina Meng (Thermo Fisher Scientific, United States)
Suzanne Bezstarosti (Leiden University Medical Center, Netherlands)
Michelle Yap (Thermo Fisher Scientific, United States)
Ujjwala Singh (Thermo Fisher Scientific, United States)
Laura Scott (Thermo Fisher Scientific, United States)
Fred Quiroz (Thermo Fisher Scientific, United States)
Ned Van Eps (Thermo Fisher Scientific, United States)
Eric Hui (Thermo Fisher Scientific, United States)
David Suh (Thermo Fisher Scientific, United States)
Quansheng Zhu (Thermo Fisher Scientific, United States)
Rui Pei (Thermo Fisher Scientific, United States)
Cynthia Kramer (Leiden University Medical Center, Netherlands)
Frans Claas (Leiden University Medical Center, Netherlands)
Dave Lowe (Thermo Fisher Scientific, United States)
Sebastiaan Heidt (Leiden University Medical Center, Netherlands)
Site-directed mutagenesis of HLA molecules reveals the amino acids crucial for monoclonal antibody binding (abstract)
PRESENTER: Tina Meng
14:40
Suzanne Bezstarosti (Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Marlies E. J. Reinders (Dept of Internal Medicine, Erasmus MC Transplantation Institute, University Medical Center Rotterdam, the Netherlands, Netherlands)
Johan W. de Fijter (Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands, Netherlands)
Sebastiaan Heidt (Dept of Immunology, Leiden University Medical Center & Eurotransplant Reference Laboratory, Leiden, the Netherlands, Netherlands)
Tacrolimus withdrawal after mesenchymal stromal cell therapy is associated with donor-specific antibody formation in kidney transplant recipients (abstract)
14:50
Christina Bade-Doeding (Hanover Medical School, Germany)
Philipp Schleumann (Hanover Medical School, Germany)
Kristin Collmann (Hanover Medical School, Germany)
Wiebke Hiemisch (Hanover Medical School, Germany)
Susann Placzko (Hanover Medical School, Germany)
Rainer Blasczyk (Hanover Medical School, Germany)
The IgG panel from peripheral CD38+/138+ B cells represents a resilient surrogate marker for safe donor/recipient matching (abstract)
15:00
Salla Markkinen (Finnish Red Cross Blood Service, Finland)
Ilkka Helanterä (Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Finland)
Jouni Lauronen (Finnish Red Cross Blood Service, Finland)
Marko Lempinen (Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Finland)
Jukka Partanen (Finnish Red Cross Blood Service, Finland)
Kati Hyvärinen (Finnish Red Cross Blood Service, Finland)
Genome-wide mismatch and deletion analysis in kidney transplantation (abstract)
PRESENTER: Salla Markkinen
15:10
Asimina Fylaktou (National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital of Thessaloniki, Greece)
Efstratios Kassimatis (Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Greece)
Anna Boukla (National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital of Thessaloniki, Greece)
Erasmia Sampani (Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Greece)
Marianthi Papachristou (National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital of Thessaloniki, Greece)
Georgios Lioulios (Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Greece)
Georgia Chatzika (National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital of Thessaloniki, Greece)
Evangelia Sidira (National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital of Thessaloniki, Greece)
Fani Makrovasili (National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital of Thessaloniki, Greece)
Maria Stangou (Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Greece)
Aikaterini Papagianni (Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Greece)
Georgios Tsoulfas (Department of Surgery, Aristotle University School of Medicine, Thessaloniki, Greece, Greece)
Association of SARS-CoV-2 vaccination with the development of anti-HLA antibodies in kidney transplant recipients (abstract)
PRESENTER: Asimina Fylaktou
14:00-15:30 Session 19C: Abstract Session: SARS-Cov-2 and miscellaneous (O65-O72)
Chairs:
Ilias Doxiadis (Leipzig University, Germany)
Jill Hollenbach (UCSF, United States)
14:00
Johannes Schetelig (Clinical Trials Unit, DKMS,Dresden; University Hospital Carl Gustav Carus, Dresden, Germany)
Falk Heidenreich (Clinical Trials Unit, DKMS, Dresden; University Hospital Carl Gustav Carus, Dresden, Germany)
Henning Baldauf (Clinical Trials Unit, DKMS, Dresden, Germany)
Sarah Trost (Clinical Trials Unit, DKMS, Dresden, Germany)
Bose Falk (Clinical Trials Unit, DKMS, Dresden, Germany)
Christian Hoßbach (Clinical Trials Unit, DKMS, Dresden, Germany)
Ruben Real (Clinical Trials Unit, DKMS, Dresden, Germany)
Elke Rücker-Braun (Clinical Trials Unit, DKMS, Dresden; University Hospital Carl Gustav Carus, Dresden, Germany)
Dana Vu Van (Clinical Trials Unit, DKMS, Dresden; University Hospital Carl Gustav Carus, Dresden, Germany)
Vinzenz Lange (DKMS Life Science Lab, Dresden, Germany)
Jan Markert (DKMS, Stem Cell Donor Registry, Tübingen, Germany)
Ralf Barth (DKMS, Stem Cell Donor Registry, Tübingen, Germany)
Jan A. Hofmann (DKMS, Stem Cell Donor Registry, Tübingen, Germany)
Jürgen Sauter (DKMS, Stem Cell Donor Registry, Tübingen, Germany)
Stefanie N. Bernas (DKMS, Stem Cell Donor Registry, Tübingen, Germany)
Alexander H. Schmidt (Clinical Trials Unit, DKMS, Dresden; DKMS Life Science Lab, Dresden; DKMS, Stem Cell Donor Registry, Tübingen, Germany)
HLA-ASSOCIATION STUDY WITH MORE THAN 16,000 PARTICIPANTS SHOWS NO HETEROZYGOTE ADVANTAGE FOR COVID-19 AND NO PROTECTIVE HLA-GENOTYPES (abstract)
14:10
Shay Ben Shachar (Clalit health services, Israel)
Noam Barda (Clalit health services, Israel)
Sapir Israeli (Bar ILan University, Israel)
Sigal Manor (Ezer Mitzion, Israel)
Yoram Louzoun (Bar Ilan University, Israel)
MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population (abstract)
PRESENTER: Yoram Louzoun
14:20
Pier Edoardo Rovatti (IRCCS San Raffaele Scientific Institute, Milano, Italy)
Marco Punta (IRCCS San Raffaele Scientific Institute, Milano, Italy)
Anna Maria Gallina (IBMDR - Registro nazionale Donatori di Midollo Osseo, Genova, Italy)
Vinzenz Lange (DKMS Life Science Lab, Dresden, Germany)
Maria Antonietta Saracino (Ospedale dell'Angelo, Venezia, Italy)
Sandro Orrù (Ospedale Binaghi, Cagliari, Italy)
Laura Castellani (ASST Papa Giovanni XXIII, Bergamo, Italy)
Rossana Mineri (Humanitas Clinical and Research Center, Milano, Italy)
Lia Mele (Azienda Ospedaliera S.S. Antonio e Biagio e C. Arrigo, Alessandria, Italy)
Graziella Carella (Spedali Civili, Brescia, Italy)
Elena Borotti (Ospedale Guglielmo da Saliceto, Piacenza, Italy)
Rita Tognellini (Azienda Ospedaliera Perugia, Perugia, Italy)
Annamaria Pasi (IRCCS Policlinico San Matteo, Pavia, Italy)
Marco Andreani (Transplantation Immunogenetics Laboratory, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy, Italy)
Cinzia Marina Tagliaferri (Ospedale S. Bortolo, Vicenza, Italy)
Cinzia Vecchiato (Gesundheitsbezirk Bozen I Comprensorio Sanitario Di Bolzano, Bolzano, Italy)
Laura Perotti (AO S. Croce e Carle di Cuneo, Cuneo, Italy)
Alexander Schmidt (DKMS Life Science Lab, Dresden, Germany)
Fabio Ciceri (IRCCS San Raffaele Scientific Institute, Italy)
Nicoletta Sacchi (IBMDR - Registro nazionale Donatori di Midollo Osseo, Genova, Italy)
Roberto Crocchiolo (ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy)
Valeria Miotti (Azienda Sanitaria Integrata Friuli Centrale, Udine, Italy)
Luca Vago (IRCCS San Raffaele Scientific Institute, Italy)
Results from the HLACOVID-ITALIA study: an unexpected correlation between HLA-DP antigen load and COVID-19 severity (abstract)
14:30
Roberto Crocchiolo (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Anna Maria Gallina (Italian Bone Marrow Donor Registry, Italy)
Arianna Pani (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Daniela Campisi (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Valeria Cento (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Nicoletta Sacchi (Italian Bone Marrow Donor Registry, Italy)
Valeria Miotti (Santa Maria della Misericordia University Hospital, Italy)
Oscar Matteo Gagliardi (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Federico D'Amico (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Chiara Vismara (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Giorgia Cornacchini (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Giuliana Lando (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Irene Cuppari (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Francesco Scaglione (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Silvano Rossini (ASST Grande Ospedale Metropolitano Niguarda, Italy)
Polymorphism of the HLA system and weak antibody response to BNT162b2 mRNA vaccine (abstract)
14:40
Hernani Gil-Julio (Hospital Universitario Virgen de las Nieves, Spain)
Francisco Perea (IBS Granada, Spain)
Cristina Torres (Hospital Universitario Virgen de las Nieves, Spain)
Jose Manuel Cozar (Hospital Universitario Virgen de las Nieves, Spain)
Federico Garrido (University of Granada, Spain)
Natalia Aptsiauri (University of Granada, Spain)
Francisco Ruiz-Cabello (University of Granada, Spain)
Loss of tumor HLA class I and PD-L1 expression in bladder cancer is associated with higher tumor grade and poor survival prognosis (abstract)
14:50
Milena Ivanova (Department of Clinical Immunology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria)
Gergana Tsvetkova (Department of Clinical Hematology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria)
Lukanov Tsvetelin (Department of Clinical Immunology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria)
Iliana Micheva (Clinic of Hematology, University Hospital Sveta Marina, Medical University, Varna, Bulgaria)
Evgueniy Hadjiev (Department of Clinical Hematology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria)
Velizar Shivarov (Department of Genetics, Faculty of Biology, St. Kliment Ohridski Sofia University, Sofia; ICON plc., Sofia, Bulgaria)
HLA class II immune editing in JAK2V617 and CALR mutation driven oncogenesis (abstract)
PRESENTER: Milena Ivanova
15:00
Jukka Partanen (FRC Blood Service, R&D, Finland)
Kati Hyvärinen (FRC Blood Service, Finland)
Satu Koskela (Finnish Red Cross Blood Service, Finland)
Jarmo Ritari (Finnish Red Cross Blood Service, R&D, Finland)
HLA-disease association and pleiotropy landscape in over 235 000 Finns (abstract)
PRESENTER: Jukka Partanen
15:10
Steven Koetzier (Maastricht University Medical Center+ (Abstract from Erasmus MC), Netherlands)
Jamie van Langelaar (Erasmus MC, Netherlands)
Marie-José Melief (Erasmus MC, Netherlands)
Annet Wierenga-Wolf (Erasmus MC, Netherlands)
Malou Janssen (Erasmus MC, Netherlands)
Cato Corsten (Erasmus MC, Netherlands)
Katelijn Blok (Erasmus MC, Netherlands)
Cindy Hoeks (Hasselt University, Belgium)
Bieke Broux (Hasselt University, Belgium)
Beatrijs Wokke (Erasmus MC, Netherlands)
Marvin van Luijn (Erasmus MC, Netherlands)
Joost Smolders (Erasmus MC, Netherlands)
Functional impact of coding risk variant RUNX3 on brain-homing CD8+ T cells in multiple sclerosis (abstract)
PRESENTER: Steven Koetzier
14:00-15:30 Session 19D: Hands On Teaching Session: Case studies - Permissiveness of DSAs: to Transplant or Not?
Location: Berlagezaal
14:00
Christine Voorter (Maastricht UMC, Netherlands)
Case studies on DSA
14:22
Laura Bungener (UMC Groningen, Netherlands)
Case studies on DSA
14:44
Michael Eikmans (LUMC, Netherlands)
Case studies on DSA
15:06
Arnold van der Meer (Radboud UMC, Netherlands)
Case studies on DSA
15:30-16:00Coffee Break
16:00-17:30 Session 21A: Plenary session: Future Perspectives in Stem Cell Transplantation
Chairs:
Luca Vago (IRCCS San Raffaele Scientific Institute, Italy)
Adriaan van Beek (LUMC, Netherlands)
16:00
Ronjon Chakraverty (Oxford University, UK)
Cell- and tissue-specific cellular and molecular mechanisms that influence tolerance vs anti-tumor immunity upon allo-SCT
16:30
Effie Petersdorf (Fred Hutchinson Cancer Research Center, United States)
HLA-DQA/DQB permissiveness in stem cell transplantation
17:00
Jurgen Kuball (UMC Utrecht, Netherlands)
gd-T cells and future perspectives of stem cell transplantation
Friday, May 20th

View this program: with abstractssession overviewtalk overview

08:30-10:00 Session 23: Best Abstract Session (O1-O8)
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
Luca Vago (IRCCS San Raffaele Scientific Institute, Italy)
08:30
Juliette Krop (Leiden University Medical Center department of Immunology, Netherlands)
Manon Bos (Leiden University Medical Center department of Pathology, Netherlands)
Lotte van Meeren (Leiden University Medical Center department of Pathology, Netherlands)
Marieke Ijsselsteijn (Leiden University Medical Center department of Pathology, Netherlands)
Kyra Dijkstra (Leiden University Medical Center department of Pathology, Netherlands)
Floor den Hollander (Leiden University Medical Center department of Immunology, Netherlands)
Kitty Bloemenkamp (University Medical Center Utrecht department of Obstetrics, Netherlands)
Marie-Louise van der Hoorn (Leiden University Medical Center department of Obstetrics, Netherlands)
Emily Cornish (University College London Elizabeth Garrett Anderson Institute for Women’s Health, UK)
Peter Nikkels (University Medical Center Utrecht department of Pathology, Netherlands)
Noel de Miranda (Leiden University Medical Center department of Pathology, Netherlands)
Frans Claas (Leiden University Medical Center department of Immunology, Netherlands)
Sebastiaan Heidt (Leiden University Medical Center department of Immunology, Netherlands)
Michael Eikmans (Leiden University Medical Center department of Immunology, Netherlands)
One-Sided Chronic Intervillositis of Unknown Etiology in Dizygotic Twins display increased numbers of CD38+/HLA-DR+ macrophages in the affected twin. (abstract)
PRESENTER: Juliette Krop
08:40
Anna Christina Dragon (Hannover Medical School (MHH), Germany)
Agnes Bonifacius (Hannover Medical School (MHH), Germany)
Nadine Wenzel (Hannover Medical School (MHH), Germany)
Stefan Lienenklaus (Hannover Medical School (MHH), Germany)
Michael Hudecek (Universitätsklinikum Würzburg, Germany)
Constanca Ferreira de Figueiredo (Hannover Medical School (MHH), Germany)
Rainer Blasczyk (Hannover Medical School (MHH), Germany)
Britta Eiz-Vesper (Hannover Medical School (MHH), Germany)
Engineered T cells overcoming rejection by antibodies (CORA-T cells) through selective targeting of alloreactive B cells in solid organ transplantation (abstract)
08:50
Hiroko Miyadera (University of Tsukuba, Japan)
Jiang Nian (University of Tsukuba, Japan)
HLA class II binding analysis for variants of SARS-CoV-2 Spike (abstract)
PRESENTER: Hiroko Miyadera
09:00
Danillo Augusto (University of California, San Francisco, United States)
Gonzalo Montero-Martin (Stanford University, United States)
Stacy Caillier (University of California, San Francisco, United States)
Adam Santaniello (University of California, San Francisco, United States)
Jorge Oksenberg (University of California, San Francisco, United States)
Marcelo Fernández-Viña (Stanford University, United States)
Jill Hollenbach (University of California, San Francisco, United States)
Specific amino acids of HLA-DPB1 are strongly associated with Amyotrophic Lateral Sclerosis (abstract)
PRESENTER: Danillo Augusto
09:10
Ilse Gille (Leiden University Medical Center, Netherlands)
Renate S. Hagedoorn (Leiden University Medical Center, Netherlands)
Manon Vergunst (Leiden University Medical Center, Netherlands)
Mirjam H.M. Heemskerk (Leiden University Medical Center, Netherlands)
Sebastiaan Heidt (Leiden University Medical Center, Netherlands)
Chimeric HLA-Antigen Receptor (CHAR) T-cell development – a new approach to target HLA sensitization (abstract)
PRESENTER: Ilse Gille
09:20
Pietro Crivello (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Esteban Arrieta-Bolaños (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Meilun He (Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, United States)
Tao Wang (Division of Biostatistics, Medical College of Wisconsin,, United States)
Shahinaz M. Gadalla (Division of Cancer Epidemiology and Genetics, National Cancer Institute,, United States)
Sophie Paczesny (Medical University of South Carolina, United States)
Steven G. E. Marsh (Anthony Nolan Research Institute, UK)
Stephanie J. Lee (Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, United States)
Stephen R. Spellman (Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, United States)
Yung-Tsi Bolon (Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, United States)
Katharina Fleischhauer (Institute for Experimental Cellular Therapy, University Hospital Essen, Germany)
Immunopeptidome divergence of HLA class I mismatches predicts survival after 9/10 matched unrelated stem cell transplantation (abstract)
PRESENTER: Pietro Crivello
09:30
Sapir Israeli (Bar ILan University, Israel)
Martin Maiers (National Marrow Donor Program, United States)
Loren Gragert (Tulane, United States)
Yoram Louzoun (Bar Ilan University, Israel)
HLA haplotype frequency estimation for heterogeneous populations using a graph-based imputation algorithm (abstract)
PRESENTER: Yoram Louzoun
10:00-11:30 Session 24: Plenary session: State of the Art: COVID-19
Chairs:
Joannis Mytilineos (Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Germany)
John Trowsdale (Cambridge University, UK)
10:00
Marc Bonten (UMC Utrecht, Netherlands)
How the Sars-Cov2 pandemic unfolded
10:30
Jill Hollenbach (UCSF, United States)
Immunogenetics and COVID-19
11:00
Juliane Walz (University Tuebingen, Germany)
Sars-Cov2 peptide presentation and immune response
12:00-13:00 Session 25: Special Session: Reports From the 18th IHIWS
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
13:00-14:30 Session 26: Closing Ceremony
Chairs:
Sebastiaan Heidt (LUMC, Netherlands)
Ann-Margaret Little (NHS, UK)
Eric Spierings (European Federation for Immunogenetics, Netherlands)
13:00
Victor Mids (Victor Mids, Netherlands)
Neuromagic
13:45
Steven Marsh (Anthony Nolan, UK)
Jon van Rood Award and Best Abstract Awards
14:00
Kirsten Geneugelijk (UMC Utrecht, Netherlands)
Best Poster Awards
14:15
Closing Remarks