PROGRAM
Days: Thursday, May 17th Friday, May 18th Saturday, May 19th Sunday, May 20th Monday, May 21st
Thursday, May 17th
View this program: with abstractssession overviewtalk overview
08:30-16:00 Session FV: Pre-IBANGS Satellite Meeting, Functional Validation for Neurogenetics
Location: Phillips Hall in the Siebens building room 1-11. The Siebens building is located at the Downtown Mayo Clinic Campus (not the Mayo Civic Center).
Description:The transformative nature of next generation sequencing has changed how neuroscientists approach genomic sequence variation. Highly multiplexed molecular testing is providing an expanded level of information from which to make informed phenotypic predictions. The importance of this is reflected in the unprecedented expansion of genomic testing to determine the basis of neurologic conditions. Genomic testing results in many instances provide a definitive basis of a neurologic condition. However, in almost a high proportion of cases, the genomic sequencing results are confounded by the ambiguity of variants with uncertain clinical significance. Herein lies the key with which institutions will lead in the area of genomic medicine. There exists a critical need to provide a mechanism by which uncertain findings can be functionally characterized and translated into clinically actionable results. It is within thisr ealm that academic societies such as IBANGS can have a substantial and informative role on the future of clinical research and practice. This symposium will introduce the challenges and opportunities that exist in the field of human clinical neurogenetics and follow this with presentations of active work in the field of functional genetic finding validation for neurogenetics with a look to the future of genomic neurogenetics.
Chairs:
Location: Phillips Hall (Siebens 1-11)
17:00-20:00 Session Reg
Meeting Registration and Information
Chair:
Location: Mayo Civic Center Grand Lobby West
18:25-18:30 Session 1: Presidential Welcome
Welcome by Society President and Introduction to Plenary Speaker
Chair:
Location: Mayo Civic Center 102/103
19:30-20:30 Session : Welcome Reception
Welcome Reception
Location: Mayo Civic Center Grand Lobby South & Riverfront Plaza
21:00-22:00 Session : Dinner on your own
Dinner on your own
Friday, May 18th
View this program: with abstractssession overviewtalk overview
08:30-10:30 Session 2: Symposium 1
Structure and function of circuits encoding sensory stimuli.
Chair:
Location: Mayo Civic Center 102/103
| 08:30 | Flexible sensory neural circuits represent chemosensory stimuli in C. elegans ( abstract ) |
| 08:55 | Topography heterogeneity at a central auditory synapse ( abstract ) |
| 09:20 | Insights into the sensory deficits caused by mutation of the deafness genes tomt and tmie ( abstract ) |
| 09:45 | The fat tastes different - the taste perception and discrimination of fatty acids in Drosophila ( abstract ) |
| 10:10 | Pregnancy associated plasma protein-aa (Pappaa) regulates photoreceptor synaptic development to mediate visually guided behavior ( abstract ) |
11:00-12:30 Session 3: Outstanding Travel Awardees
Junior Faculty, Postdoctoral, and Student Outstanding Travel Awardees
Chair:
Location: Mayo Civic Center 102/103
| 11:00 | Sex-dependent effects of toll-like-receptor 3 activation on alcohol intake ( abstract ) |
| 11:23 | Transgenerational effects of nicotine exposure on fear learning, gene expression, and cholinergic signaling ( abstract ) |
| 11:46 | Gene x Diet Interactions Modify Symptoms of Alzheimer’s Disease ( abstract ) |
| 12:08 | Joint contributions of rare CNVs and common SNPs to risk for schizophrenia ( abstract ) |
13:30-15:30 Session 4: Selected Talks I
Selected Talks 1
Chair:
Location: Mayo Civic Center 102/103
| 13:30 | Molecular and behavioral assessment of long non-coding RNAs in alcohol use disorder ( abstract ) |
| 13:45 | Adenosine A2A Receptor in the Dorsomedial Striatum Regulates Alcohol-Seeking Behavior though Top-Down Inhibitory Pathway ( abstract ) |
| 14:00 | Cocaine’omics: The Genetic and Neurological Underpinnings of Cocaine Use and Dependence – An Unorthodox Replication ( abstract ) |
| 14:15 | Genome-wide transcriptional changes in the rat hippocampus during withdrawal from chronic alcohol drinking identifies altered neuroimmune signaling ( abstract ) |
| 14:30 | Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex is blunted in Rats with a Family History of Excessive Drinking ( abstract ) |
| 14:45 | Systems genetics, fine mapping, and validation of candidate genes involved in opioid and psychostimulant addiction traits in a reduced complexity cross ( abstract ) |
| 15:00 | Using genome-wide association and RNA sequencing to identify genes associated with ethanol sensitivity in Diversity Outbred mice ( abstract ) |
| 15:15 | Evaluation of Nav1 as a candidate gene influencing intravenous cocaine self-administration in inbred mice ( abstract ) |
16:00-18:00 Session P1: Poster Session I
Poster Session 1
Location: Mayo Civic Center 104, 105, 106
| 16:00 | 1. Mapping neuro-pharmacological effect of harmaline in pig ( abstract ) |
| 16:00 | 3. Mapping a novel endocrine circuit regulating alcohol consumption ( abstract ) |
| 16:00 | 5. A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex ( abstract ) |
| 16:00 | 7. Glucocorticoid regulation of ependymal glia and regenerative potential after vertebrate spinal cord injury ( abstract ) |
| 16:00 | 9. CRISPR/dCas9 manipulation of Bdnf transcription in rat primary hippocampal neurons ( abstract ) |
| 16:00 | 11. Genome-wide transcriptional changes in the rat hippocampus during withdrawal from chronic alcohol drinking identifies altered neuroimmune signaling ( abstract ) |
| 16:00 | 13. Adenosine A2A Receptor in the Dorsomedial Striatum Regulates Alcohol-Seeking Behavior though Top-Down Inhibitory Pathway ( abstract ) |
| 16:00 | 15. Hospital Pharmacists' Knowledge of Pharmacogenetics in Saudi Arabia ( abstract ) |
| 16:00 | 17. Functional evaluation of a novel mutation in DOCK3 associated with neurological symptoms ( abstract ) |
| 16:00 | 19. Sink or Swim: Impacts of prolonged stress on zebrafish physiology and behavior ( abstract ) |
| 16:00 | 21. Systems genetics discovery of genetic, genomic, and gene-by-environment mechanisms driving substance use and sensation seeking ( abstract ) |
| 16:00 | 23. Genetic analysis of ethanol-stimulated locomotion in food-deprived and fed flies ( abstract ) |
| 16:00 | 25. Regulation of neuron communication and development by the matricellular protein dCCN ( abstract ) |
| 16:00 | 27. Utilizing the BXD genetic reference panel to identify the causal genetic variants of nicotine withdrawal deficits in hippocampal learning ( abstract ) |
| 16:00 | 29. Effects of prenatal stress on the behavior of Fmr1 knock-out mice ( abstract ) |
| 16:00 | 31. A function investigation of novel Y chromosome encoded long non-coding RNAs expressed in human male CNS during early development ( abstract ) |
| 16:00 | 33. The role of Phosphodiesterase type 4 (Pde4) in chronic binge-like drinking ( abstract ) |
| 16:00 | 35. Fragile X mental retardation protein regulates dendritic branching and spine morphology in the striatum following repeated cocaine administration. ( abstract ) |
| 16:00 | 37. Translational Model Improvement for Alcohol Use Disorder: Voluntary Consumption Behavior in Hybrid Swine ( abstract ) |
| 16:00 | 39. Effects of genetic deletion of Syn3 on operant reversal learning in mice ( abstract ) |
| 16:00 | 41. Heritable variation in voluntary alcohol drinking in a genetically diverse inbred mouse panel ( abstract ) |
| 16:00 | 43. Modeling the subtypes of depression on the basis of identification of syndrome patterns from two inbred mouse strains ( abstract ) |
| 16:00 | 45. Structure-function analysis of Slitrk proteins and the consequences of gene variants ( abstract ) |
| 16:00 | 47. Selection for MA intake in mice with a non-functional trace amine-associated 1 receptor and examination of genetically correlated MA-related traits ( abstract ) |
| 16:00 | 49. C. elegans as a Neurological Model for Duchenne Muscular Dystrophy ( abstract ) |
| 16:00 | 51. Effectiveness of exercise in a nematode model of Duchenne Muscular Dystrophy: improvements in mobility following an endurance exercise regimen ( abstract ) |
| 16:00 | 53. Behavioral characterization of a mouse model of Wolfram Syndrome 2 ( abstract ) |
| 16:00 | 65. Triangulating on the neuroanatomical and cell biological mechanisms by which hnRNP H1 haploinsufficiency results in reduced methamphetamine-induced dopamine release and behavior ( abstract ) |
| 16:00 | 55. Dynamic alternative polyadenylation events in the nucleus accumbens of alcohol consuming rats ( abstract ) |
| 16:00 | 57. Behavioral characterization of β-arrestin-1 knockout mice in anxiety-like, seizure, and alcohol-drinking behavior ( abstract ) |
| 16:00 | 59. Transgenic crustaceans: adaptation of modern molecular technology to the study of neural function in decapods ( abstract ) |
| 16:00 | 61. The SLC6A3 gene variants and reduction of dopamine transporter availability may have a role in susceptibility to alcohol use disorder ( abstract ) |
| 16:00 | 63. Age and genetic background influence initial nicotine sensitivity in C57BL/6J and DBA/2J mice ( abstract ) |
18:00-21:00 Session : Dinner on your own
Dinner on your own
Saturday, May 19th
View this program: with abstractssession overviewtalk overview
08:30-09:30 Session Reg: Registration
Meeting Registration
Location: Mayo Civic Center Grand Lobby West
09:00-09:10 Session 5: Mayo Clinic Welcome
Chair:
Location: Mayo Civic Center 102/103
| 09:00 | Mayo Clinic Welcomes the 20th Annual Genes, Brain, and Behavior Meeting ( abstract ) |
09:10-11:10 Session 6: Symposium 2
Circadian roles in psychiatric and neural disorders
Chair:
Location: Mayo Civic Center 102/103
| 09:10 | Eaat2 functions in ensheathing glia to regulate of sleep and metabolic function ( abstract ) |
| 09:40 | Circadian roles of in psychiatric diseases – insights from zebrafish ( abstract ) |
| 10:10 | NPAS2 Regulation of Anxiety-Like Behavior ( abstract ) |
| 10:40 | Impact of circadian nuclear receptor NR1D1 on central dopaminergic system and its implications for bipolar disorder ( abstract ) |
11:35-12:35 Session 7: Young Investigator Awards
Young Investigator Awardees
Chairs:
Location: Mayo Civic Center 102/103
| 11:35 | Systems genetics reveals novel mechanisms underlying resilience to Alzheimer’s Disease ( abstract ) |
| 12:05 | Circuits and molecules driving cue-induced alcohol preference in Drosophila ( abstract ) |
13:30-15:30 Session 8: Symposium 3
Rapid, non-genomic glucocorticoid signaling and its impact on behaviors
Chair:
Location: Mayo Civic Center 102/103
| 13:30 | Acute stress-induced desensitization of CRH neurons to norepinephrine via rapid glucocorticoid regulation of adrenoreceptor trafficking ( abstract ) |
| 14:00 | Roles for organic cation transporter 3 (OCT3), a glucocorticoid-sensitive monoamine transporter, in stress-induced regulation of dopamine clearance and behavior ( abstract ) |
| 14:30 | Rapid actions of corticosterone as function of the circadian rhythm and the implication for fear learning ( abstract ) |
| 15:00 | Locomotor response to acute stressors requires hypothalamic-pituitary-interrenal axis activation and glucocorticoid receptors in zebrafish ( abstract ) |
16:00-18:00 Session P2: Poster Session II
Poster Session 2
Location: Mayo Civic Center 104, 105, 106
| 16:00 | 2. Investigating the Association of X Chromosome Genetic Variants with Sex-Specific Symptoms of Bipolar Disorder ( abstract ) |
| 16:00 | 4. Dynamic Mapping of Genomic Architecture in vivo. ( abstract ) |
| 16:00 | 6. A mechanism of public misunderstanding of animal behavior genetics research ( abstract ) |
| 16:00 | 8. GABRA2 genetic variants and chromosome conformation in induced pluripotent stem cell-derived neural cultures ( abstract ) |
| 16:00 | 10. Alcohol-Intoxicated Flies Become Aggressive ( abstract ) |
| 16:00 | 12. Cocaine’omics: The Genetic and Neurological Underpinnings of Cocaine Use and Dependence – An Unorthodox Replication ( abstract ) |
| 16:00 | 14. Drosophila NfKB Dif shows splice variant specificity in ethanol response ( abstract ) |
| 16:00 | 16. First cohort of patients with novel KCNK9 variants: gain and loss of function cause Birk-Barel mental retardation dysmorphism syndrome ( abstract ) |
| 16:00 | 18. The Genetic Landscape of Familial Congenital Hydrocephalus ( abstract ) |
| 16:00 | 20. A relatively enriched environment delays binge onset but does not affect binge size ( abstract ) |
| 16:00 | 22. SSRIs and serotonin transporter impact on bone: How zebrafish inform personalized medicine ( abstract ) |
| 16:00 | 24. Neuronal Expression Represented in The Gene Breaking Transposon Library ( abstract ) |
| 16:00 | 26. Differential Brain Gene Co-expression Between Saline and Ethanol Treated Recombinant Inbred Mice ( abstract ) |
| 16:00 | 28. Functional testing of patient DNA variants implicated in neuronal phenotypes ( abstract ) |
| 16:00 | 30. Novel Y chromosome encoded long non-coding RNAs (Y-lncs) expressed in human male CNS during early development ( abstract ) |
| 16:00 | 32. An Investigation of Genes Involved in the Regulation of Novel Alcohol Behaviors (Alcohol Induced Aggression and Courtship Receptivity) in Drosophila melanogaster ( abstract ) |
| 16:00 | 34. Differential regulation of excessive alcohol consumption by the transcriptional regulator LMO4 ( abstract ) |
| 16:00 | 36. The Role of Astrocytic Glutamate Transporter 1 (GLT1) in Psychiatric Disorders ( abstract ) |
| 16:00 | 38. Development of a novel assay to identify genes involved in host infection by parasitic nematodes ( abstract ) |
| 16:00 | 40. Altruistic allogrooming in subordinate male mice ( abstract ) |
| 16:00 | 42. Heritable variation in reward sensitivity and impulsive action and choice in a genetically diverse inbred mouse panel ( abstract ) |
| 16:00 | 44. TAAR1 mediates the aversive effects of methamphetamine in a genetic mouse model of low methamphetamine intake ( abstract ) |
| 16:00 | 46. Genetic differences in mice in neuroinflammatory effects of exposure to organophosphates ( abstract ) |
| 16:00 | 48. PHOX2B regulates development of nested astrocytes that control breathing and sleep homeostasis ( abstract ) |
| 16:00 | 50. High-throughput phenomic characterization of ASD-associated genes reveals a functional gene network underlying hypersensitivity and impaired habituation ( abstract ) |
| 16:00 | 52. Optimization of behavioral search strategies to cues of distinct physical natures ( abstract ) |
| 16:00 | 54. Behavioral effects of RNAi-mediated silencing of gap junction proteins in Marbled Crayfish ( abstract ) |
| 16:00 | 56. Genetic differences in the behavioral organization of binge eating, conditioned food reward, and compulsive-like eating in C57BL/6J and DBA/2J mice and in an F2 cross ( abstract ) |
| 16:00 | 58. Trace amine-associated receptor 1 functionality can dictate some methamphetamine-related behaviors ( abstract ) |
| 16:00 | 60. Frailty as a measure of healthspan and lifespan in transgenic mice ( abstract ) |
| 16:00 | 62. AAV Mediated MiR-138 Injections into the Medial Habenula of Mice Reduces Nicotine Consumption ( abstract ) |
| 16:00 | 64. Uncovering the role of the oculocutaneous albinism 2 gene in the evolution of behavior in the Mexican cavefish Astyanax mexicanus ( abstract ) |
| 16:00 | 66. Genetic variation interacts with experience to determine inter-individual differences in learned song ( abstract ) |
18:00-21:00 Session : Dinner on your own
Dinner on your own
Sunday, May 20th
View this program: with abstractssession overviewtalk overview
08:30-09:30 Session Reg: Registration
Meeting Registration
Location: Mayo Civic Center Grand Lobby West
09:00-10:00 Session 9: Distinguished Scientist Award
Distinguished Scientist Awardee
Chair:
Location: Mayo Civic Center 102/103
| 09:00 | Neurochemical mechanisms of addicted behaviour ( abstract ) |
10:30-12:30 Session 10: Selected Talks II
Selected Talks 2
Chair:
Location: Mayo Civic Center 102/103
| 10:30 | Genetic variation interacts with experience to determine inter-individual differences in learned song ( abstract ) |
| 10:45 | Transcriptome analysis of the hypothalamic-pituitary-adrenal axis in tame and aggressive foxes (Vulpes vulpes) ( abstract ) |
| 11:00 | Genomic targets of selection for behavior in the red fox ( abstract ) |
| 11:15 | CRISPR/dCas9 manipulation of Bdnf transcription in rat primary hippocampal neurons ( abstract ) |
| 11:30 | Whole genome sequencing of replicate inbred strains of mice selected for high and low open-field activity ( abstract ) |
| 11:45 | The adaptor protein Nck1 regulates of anxiety-like behaviours ( abstract ) |
| 12:00 | Functional Variomics Group: Precise structure-function analysis of ASD associated gene variants in PTEN using targeted CRISPR gene replacement in Caenorhabditis elegans ( abstract ) |
| 12:30 | Alcohol-Intoxicated Flies Become Aggressive ( abstract ) |
15:00-17:00 Session 12: Workshop Integrative Genomics
Description
Robert W. Williams1, Elissa J. Chesler2 University of Tennessee Health Science Center1; The Jackson Laboratory2 Systems genetics has been an effective strategy for gene discovery and for finding the relations among behavioral traits and their neurobiological mechanisms in genetic reference populations. Integrative genomics combines data from diverse experimental paradigms to find the common and distinct biological mechanisms of biological and behavioral traits within and across species. As these methods have evolved, so too have the software systems that support interactive user initiated analyses. Flexible tools have made rapid interrogation of integrative genetic and genomic data resources possible.Participants in this workshop will have an opportunity for hands on demos using thelatest versions of Gene Network, Mouse Phenome Database and GeneWeaver tools for integrative genetic and genomic analyses. These resources allow users to explore the relations among genetics, genomics, behavior and other disease related phenotypes inan interactive manner. Participants will be guided through the use of these platforms using simple tutorial demonstrations. Following the introductory tutorial demonstrations,
Chairs:
Location: Mayo Civic Center 102/103
18:00-19:00 Session : Dinner on your own
Dinner on your own
Monday, May 21st
View this program: with abstractssession overviewtalk overview
08:00-09:00 Session Registration: Registration
Meeting Registration
Location: Mayo Civic Center Grand Lobby West
08:30-10:30 Session 13: Symposium 4
Complex models, complex disorders
Chair:
Location: Mayo Civic Center 102/103
| 08:30 | Using N/NIH heterogeneous stock (HS) rats to study the genetic baiss of behavior ( abstract ) |
| 09:00 | Utilizing genetically diverse Collaborative Cross strains to investigate addiction-related behaviors ( abstract ) |
| 09:30 | Genome-Wide Association Studies of Anorexia Nervosa: A Research Update from the Anorexia Nervosa Genetics Initiative and the Eating Disorders Working Group of the Psychiatric Genomics ( abstract ) |
| 10:00 | Development of the First Pharmacotherapy for the Treatment of Usher Syndrome Type I due to Variants in MYO7A ( abstract ) |
11:00-12:30 Session 14: Selected Talks III
Selected Talks 3
Chair:
Location: Mayo Civic Center 102/103
| 11:00 | Glucocorticoid regulation of ependymal glia and regenerative potential after vertebrate spinal cord injury ( abstract ) |
| 11:15 | Sequencing the BXD family, a cohort for experimental systems genetics and precision medicine ( abstract ) |
| 11:30 | A mechanism of public misunderstanding of animal behavior genetics research ( abstract ) |
| 11:45 | Localizing Origins of Essential Tremor Phenotype in a Novel Mouse Model ( abstract ) |
| 12:00 | GABRA2 genetic variants and chromosome conformation in induced pluripotent stem cell-derived neural cultures ( abstract ) |
| 12:15 | Genetic modifiers of motor decline symptoms of Alzheimer’s disease in a novel transgenic murine panel ( abstract ) |
13:30-15:30 Session 15: Symposium 5
Neural Basis of Impulsivity in Addiction and Psychiatric Disorder
Chair:
Location: Mayo Civic Center 102/103
| 13:30 | Role of dopamine D2 receptors in impulsive behavior ( abstract ) |
| 14:00 | Serotonin 2B receptors in mesoaccumbens dopamine pathway in impulsivity and cocaine responses ( abstract ) |
| 14:30 | Clues into Cues: Serotonergic Circuits Engaged in Impulsivity and Cue Reactivity ( abstract ) |
| 15:00 | Striatal Adenosine A2A Receptor Regulates Impulsivity, Goal-Directed Alcohol Seeking Behaviors ( abstract ) |
16:00-17:00 Session 16: Keynote Address
Keynote Address
Chair:
Location: Mayo Civic Center 102/103
| 16:00 | Phenotype-based drug discovery for neurodegenerative diseases using automated neurobehavioral profiling in genetic zebrafish models ( abstract ) |
18:15-19:00 Session 18: Travel and Reception
Travel and Reception
19:00-23:00 Session : Banquet: Four Daughters Vineyard & Winery
Banquet: Four Daughters Vineyard & Winery
Chair:
Location: Four Daughters Winery
20:30-23:00 Session : Return Transportation
Return Transportation. Trolleys will leave about every 30 minutes from 8:30 until the close of the event at 11PM.