Micro Parem Patch: an Innovation of Chitosan-Based Microneedle Patch with Lempuyang (Zingiber Zerumbet) and Bangle Extract for Alternative Therapy of Osteoarthritis

EasyChair Preprint no. 11161

Abstract

Osteoarthritis (OA) is a chronic degenerative disease that occurs in joint tissue and has been considered the most dominant reason for joint disability in elderly people. OA can cause 80% of elderly people to have difficulty walking, bending or standing. The prevalence of osteoarthritis in Indonesia reaches 24.7%. However, currently available drugs for OA, such as nonsteroidal anti- inflammatory drugs (NSAIDs) and glucocorticoids, are thought to carry undesirable side effects. This study aims to examine the characterization and effectiveness of the Micro Parem Patch as an alternative therapy for osteoarthritis. Based on the FTIR test, the results show that the the results of the dissolution test and Swelling Characterization Micro Parem Patch can dissolve in the body in an average of 4 hours. Based on in-vivo tests, Micro Parem Patch had the highest analgesic effect on F2 (63%) and the lowest average writhing response (4.33). Then, Micro Parem Patch also has an anti-inflammatory effect with the optimum dose for anti-inflammatory osteoarthritis in F2 (30mg lempuyang and 40mg bangle) with an anti- inflammatory potency of 69.31%. Thus it can be concluded that the Chitosan Based Micro Parem Patch with Lempuyang (Zingiber zerumbet) Extract and Bangle Rhizome can be used as an alternative therapy for osteoarthritis

Keyphrases: Analgesic, anti-inflammatory, Chitosan, Microneedle, Osteoarthritis

@Booklet{EasyChair:11161,
  author = {Talitha Amelia Trixie and Jihan Aura and Amadeo Lemuel and Thoriq Hibatullah and Muhammad Esa Erlang and Edith Frederika Puruhito},
  title = {Micro Parem Patch: an Innovation of Chitosan-Based Microneedle Patch with Lempuyang (Zingiber Zerumbet) and Bangle Extract for Alternative Therapy of Osteoarthritis},
  howpublished = {EasyChair Preprint no. 11161},

  year = {EasyChair, 2023}}