The paper is devoted to developing the Multi-hazard Risk Assessment Framework containing models, scenarios, and methods for analyzing the risk related to multi-hazards. The multi-layered spatial model and the model of the Human-Infrastructure System based on hierarchies and having great scalability in time and space are proposed. These models take into account all possible relations between people, objects of infrastructure, natural environment, and corresponding spatial areas. The proposed event-based scenario representation model provides sufficient detailization in space and time and can properly represent multi-hazards, including compound events, cascading effects, and risk-related processes driven by environmental and societal changes. A novel extensible Multi-hazard Risk Assessment Framework that is a skeleton containing the multi-hazard risk assessment toolkit dealing with threat/danger, vulnerability, damage, coping capacity, risk and multi-risk is presented. The risk scenarios within this framework can describe multi-hazards as a multitude of spatially distributed dynamic processes influenced by various drivers. The implementation of the proposed models and framework is also considered.