Amirabad Port Special Economic Zone is the first third generation port of the Islamic Republic of Iran and the largest port on the Caspian Sea. This port, with its proper transportation infrastructure and equipment, will play a decisive role in the prosperity of the "North-South" international transport corridor as the gateway of this corridor for Iran and the Asian continent. This research is an applied research that uses library documents and resources and field surveillance to explain the role of Amirabad Port Special Economic Zone in the prosperity of the North-South International Transport Corridor. With the expansion of globalization and the removal of borders in the digital age and of course the high volume of interactions between the two continents of Asia and Europe and the cost-effectiveness of the North-South international transport corridor compared to other existing routes in terms of financial and time, the importance of the region The economic special of Amirabad port is becoming more visible. Expanding the amount of communications (via the Persian Gulf and access to open waters) and adding other countries to this corridor, and of course expanding the dimensions of communications in addition to transit discussions, can bring many changes to the countries of Asia and Europe.