Human factors play a huge role in road traffic safety. Research has found that a huge proportion of traffic crashes occur due to some form of human error. Improving road user behavior has been the major strategy that has been emphasized for improving road traffic safety. Meanwhile, despite the training efforts, and testing for drivers, the global status of road traffic safety is alarming. In the aim to turn the tide around in improving road traffic safety, there is a need to pay adequate attention to factors that can help minimize the impact of human error, or at least ensure that implications of human error do not result in undesirable consequences on the road. This study evaluates how factors such as driver distraction, fatigue, driving under the influence of drugs and alcohol, and outside objects affect the driver. The need for a reasonable degree of automation to help reduce the impacts of human factors on road safety and recommendations aimed at providing widespread support for a reasonable degree of automation systems in driving tasks is presented.