The sustainability of agricultural productivity and the security of global food supplies are two of the most urgent issues of the new millennium. To solve these concerns, agro-ecosystems' ability to adapt to a rapidly changing climate and improve global food supply while avoiding inadvertent environmental damage is crucial. By the creation of cutting-edge and smart technologies, cleaner production projects support sustainable development. Among these technologies are smart nanocarriers that can encapsulate and deliver active pesticide ingredients (AIs) in a responsive manner (e.g., controlled, targeted, and synchronized) open up new avenues for improving the efficacy and efficiency of traditional pesticides. Among the novel technologies proposed in agriculture, Metal-Organic Frameworks (MOFs) have gained a significant role as carriers for the controlled release of agrochemicals The use of safe and stable MOFs in agroindustry (mostly for environmental cleanup and agrochemical-controlled release) is required. In this study we will seek to answer the question of how the use of green bio-MOFs-based pesticide nano-formulations can lead to improved sustainable cleaner production.