The article investigates the level and scope of engagement of Ukrainian higher education and research institutions in e-infrastructures. The article consideres the impact of digital transformation on higher education and research, highlighting the role of e-infrastructures within these institutions. Among the key benefits brought about by digital transformation in the academic sphere are faster access to information, improved scientific collaboration, and data preservation. The main advantages of utilizing e-infrastructures in higher education and supporting research institutions include: access to infrastructure and resources, support for diverse scientific domains, high productivity and efficiency, integration with international initiatives, collaborative work and cooperation, ensuring security and confidentiality, and fostering the development of the national scientific and technological community. The publication provides an overview of the main types of e-infrastructures in Ukraine, including the Ukrainian National Grid, Ukrainian Research and Academic Network (URAN), GÉANT, and the National Repository of Academic Texts. The key characteristics of these e-infrastructures are described. The organization and results of the a All-Ukrainian survey conducted among higher education and research institutions regarding their levels of engagement with e-infrastructures are presented. This survey was initiated and organized by the authors of this publication with the support of the MES of Ukraine. Overall, the article demonstrates the crucial role that e-infrastructures play in the development of higher education and research in the context of digital transformation. Based on the survey results, the possibility of developing of various national and institutional policies, both general and personalized, considering the different levels of engagement with e-infrastructures for educational and research purposes in different institutions is highlighted.