This paper explores the nexus between urban spaces mobility and access, and children safety in Nairobi and Kumasi cities. It is based on research conducted in Kenya and Ghana between 2020 and 2021. Guided by Niel Brenner (2019) new urban spaces theory (Addie (2020) and the institutional approach, the study investigated whether urban spaces and infrastructure, as designed, enhanced children safe travel and mobility in Nairobi and Kumasi cities. This paper focuses on three specific study objectives that entailed: interrogating children transport safety policies and regulations in Kenya and Ghana; assessing travel needs of school-going children in Nairobi and Kumasi, mobility options and factors that influenced their choices; and exploring options for promoting safe travel and mobility for children. Data collection included documents review, children perception surveys, parents, and key informant interviews, transect walks, and focus group discussions. Most children walked to school because they lived near the schools, despite the urban spaces not being child friendly. Kenya has a school travel policy, but it does not cover all modes. In contrast, Ghana does not have such a policy, but the government educates school children on road safety. The challenges experienced by children were attributed to failure to use child lenses in conceptualisation, design and implementation of urban spaces and infrastructure; weak enforcement, fragmented state agencies and competing interests; and general ignorance on children safety measures. Hence, addressing these challenges require a multifaceted approach and recognition of the benefits of inclusive cities.