The article considers the processes of formation and development of the Zaporizhzhia cluster EAM 4.0, on the theoretical basis of smart specialization. The Quadruple Helix model gives an idea of the modern organization of innovation processes and the role of the state, business, educational institutions and civil society for the formation of the innovation environment. Also considered approaches of modern project management for the formation of a sustainable cluster management system. The basis for the creation and functioning of the Zaporizhzhia cluster is in the field of innovation and the combination of education, science, business and public interests.