Here we report the first robotic high cervical fixation and sEEG depth electrode placement using the ExcelsiusGPS robot. All surgeries were performed successfully and there were no complications.  Demonstrated benefits of robotic spine and cranial surgery are increased accuracy, decreased length of surgery and less invasiveness. Limitations specific to this study include a small sample size and a single academic center. This study demonstrates the capability of the ExcelsiusGPS robot in both spine and cranial surgeries.  Current ongoing research seeks to utilize preoperative magnetic resonance imaging instead of CT in order to further decrease radiation exposure.  Future research is warranted to quantify the healthcare cost-savings and the learning curve for these complex robotic surgeries.