The study is devoted to solving the scientific problem of optimizing the retail trade in the production and sale of two types of products, taking into account the change in potential demand for products. The economic and mathematical model of the production activity of the enterprise was developed taking into account logistics and market demand. The logistics scheme takes into account all the main links of the logistics system, as well as the connections between them. The considered scheme makes it possible to take into account the diversification of products manufactured by the enterprise. The mathematical model is designed for discrete time. A numerical optimization method has been developed for this mathematical model. The optimal solutions for several cases are found and investigated. The dynamics of the main characteristics of drugs was calculated for all considered cases. A comparative analysis of economic efficiency for the studied cases has been performed. proved the economic efficiency of optimization of the retail network.