Studies in modern universities are closely integrated with research, innovation, and knowledge transfer. Research and development activity can improve the quality of education and help to achieve the desired demands of the labor market, especially if high-tech enterprises are involved in the process. However, employers may be dissatisfied with graduates because of their unethical research practices. The latter is a complex multi-faceted phenomenon that requires a holistic response, beyond just a policy of information and sanctions. This is especially true for master and doctoral degree students involved in research and development. It is more preferable to encourage them to build their creativity and critical thinking skills as a precondition for research integrity than institutionalize policies and procedures. The aim of the paper is to develop avenues to maintain scientific integrity among second- and third-level students of higher education institutions by establishing effective cooperation between universities and high-tech enterprises in the field of research and development. The paper outlines the problem of unethical research practices, the analysis of the reasons and typology of research dishonesty is undertaken. The infrastructure, information technology, and appropriate tools for academic-industrial cooperation providing ethically sustainable research and innovation practices are proposed. High-tech enterprises are involved in feedback using monitoring and audit tools for systematic and independent examination of research and development activities of students. The adoption of developed information technology and tools will ensure scientific integrity in practice and allow teaching students to think like scientists through building their creative and innovation skills in close cooperation with leading high-tech enterprises.