The article analyzes the research that addresses the issue of using computer models in the educational process. It covers the aspects of the use of computer modelling in natural sciences subjects, namely: chemistry, biology. It analyzes the students’ interest in choosing a future profession, connected with chemistry and biology. The article offers the definition and substantiation of the model of educational computer pattern and the definition of its components (graphic, mathematical, strategic, animation) and features (mono-subject, poly-subject / simulation, play-based, algorithmic / poster, laboratory, quest / variant / character-based / achievable). It substantiates the stages of designing a research task. It covers the methodical basics of computer modelling in the implementation of a STEM lesson in chemistry. It describes the methodological basics of using computer modelling to work independently at the lessons of biology. The present research also summarizes the results of the teacher survey on the usefulness and ease of use of computer modelling in the educational process. The priorities of the students in the study of subjects of the natural and mathematical cycle are determined. Computer modelling is found to be an effective tool for improving the quality of science education that requires the development of a teacher training system, cognitive tasks and organizational foundations of the educational process