Ventricular Assist Devices (VADs) are used for mechanical circulatory assistance in patients with Congestive Heart Failure (CHF). VADs may generate pulsatile or continuous flows. Continous flow VADs may generate a more physiological flow pattern with some degree of pulsatility when the device is operated using what is referred to as a physiological controller. We present a computational simulator to be used for comparison of the hemodynamic responses of a simulated patient implanted with a VAD operated with or without a physiological controller. The computational simulator includes: (i) simulations of patient´s conditions; (ii) mathematical models of the estimators and sensors; and (iii) VAD physiological control algorithms. Application of the simulator allowed investigation of the performance of physiological control strategies considering different scenarios for VAD applications.