Lowering the emissions excessively under the legislation limits would increase the engine operating costs such as higher fuel consumption. The challenge is to fulfill the emission standards and to maximize the engine efficiency. Overcoming this problem requires more advanced combustion control than the traditional engine tuning and calibration. There have been several new approaches in the engine combustion control, which are based on new low temperature combustion technologies, e.g.\ RCCI (reactivity controlled compression ignition), HCCI (homogeneous charge compression ignition) and PPC (partially premixed combustion). Control in these is complicated however, and they are based on controlling the cylinder pressure by several successive fuel injections during each engine cycle. Engine efficiency can be increased by maintaining the cylinder pressure at its highest level throughout the combustion. Multiple injection strategy is one of the new methods being used to maximize the cylinder pressure. It is an alternative approach to single injection combustion, which has been proved to be more efficient in terms of noise and emission reduction, and fuel consumption. The multiple injection enables better control of the fuel distribution. In this work, a model predictive control (MPC) is applied for multiple injection strategy in a maritime diesel engine. The aim is to predict and control the engine combustion parameters cycle-to-cycle.