The study examined the feasibility of implementing a Blue Ocean Strategy of last-mile delivery service in Lagos, Nigeria. Last-mile delivery is a critical aspect of the supply chain characterized by intense competition and operational challenges. The Blue Ocean Strategy concept advocated creating uncontested market spaces, diverging from competition-focused strategies. This study assessed the principles of the Blue Ocean Strategy with measurements such as product leadership and differentiation used to examine whether competitiveness can be effectively achieved in the last-mile delivery sector in Lagos. A mixed-method approach was used to gather the required data for the analysis. Qualitative and quantitative methods were useful for the study. Qualitative data was gathered through interviews with industry experts, delivery personnel, and consumers to gain insights into main points, service gaps, and latent demands. Quantitative data was collected through a survey using a convenience sampling technique with a questionnaire on the infinite population of customers to gauge their perceptions, preferences, and willingness to adopt novel delivery approaches. The study found that last-mile delivery service is a blue ocean type of business in which both product leadership and product differentiation strategies can be applied to achieve competitiveness. It was further suggested that the operators of the last-mile delivery service in Lagos could adopt any of the business-level strategies of product leadership and product differentiation while considering the environment where such business is conducted.