First-order logic fragments mixing quantifiers, arithmetic, and uninterpreted predicates are often undecidable, as is, for instance, Presburger arithmetic extended with a single uninterpreted unary predicate. In the SMT world, difference logic is a quite popular fragment of linear arithmetic which is less expressive than Presburger arithmetic. Difference logic on integers with uninterpreted unary predicates is known to be decidable, even in the presence of quantifiers. We here show that (quantified) difference logic on real numbers with a single uninterpreted unary predicate is undecidable, quite surprisingly. Moreover, we prove that difference logic on integers, together with order on reals, combined with uninterpreted unary predicates, remains decidable.