New methods for characterizing FPGA performance and risk in space-radiation environments are presented. Application of the new methods are illustrated via walking through a NASA Mission use case. A requirement for the mission is to “work-through” a worst-week radiation environment with minimal ground intervention. Mitigation insertion becomes a necessity but is limited due to device capacity. This presentation shows that old test and evaluation methods are insufficient while new methods provide better characterization and assistance for determining suitable design/mitigation strategies.