The article is devoted to the study of the possibilities of digital transformation of secondary education in Ukraine to ensure the quality of teaching natural and mathematical sciences in the conditions of war. The analysis of scientific and methodological literature on the digital transformation of secondary education made it possible to single out tools for self-assessment by educational institutions of their activities and highlight the main indicators, recommendations for the introduction of digital technologies and ensuring quality science, mathematics education in war conditions. Empirical research methods such as a qualitative approach using interviews and focus groups as methods of data collection and statistical methods made it possible to draw conclusions about the levels of digital competence of teachers and students, their understanding of the digital transformation of education and the influence of its components on the implementation of quality science and mathematics education. During the study, hypotheses were confirmed regarding the positive impact of increasing the level of digital competence of teachers on the attitude and readiness for digital transformation, the impact of digital transformation on the quality of science and mathematics education in war conditions, and the need to consider the characteristics of children to increase their positive motivation.