Flood-prone areas have been existed and considered a barrier to reaching sustainable development goals in many countries. Exposed to the ongoing expansion of disturbing development, it is necessary to identify flood-related sources as flood driving forces in flood-prone areas to find new approaches from a public-sector perspective that trying to manage imminent flood risk. Nevertheless, studies on challenges and barriers relevant to the implementation of flood risk management approaches for flood-prone areas are scarce. For responding to the gap, the objective of this research is to support a deeper and more detailed analysis of the most important driving forces through the examination of flood driving forces in Cantho city which located in the Mekong River basin. The research conducted by examining the secondary data based on many sources as well as development plans within the public sector. Findings show that flood driving forces, as processes or trends that contributed to the flood-vulnerability status, possibly increasing flood risk and forming the flood-prone area including human-made driving forces: population growth, land-use change, urban expansion, and drainage network. Flood driving forces are accelerated long-term processes; therefore, these issues demand adequate approaches to handle changes that are associated with the human-made context.