The space compute solution NASA/JPL flies today has architectural origins dating all the way back to the mid 1990’s.  With NASA/JPL missions on a trajectory to employ higher and higher levels of autonomy in the coming years to meet our science and exploration objectives, the current space compute solution does not have the capability to well-serve that trajectory.  This presentation covers the major limitations of current space compute solutions, when viewed through the lens of powering the level of autonomy that next-generation space exploration is likely to require.  And flipping that around, this presentation also covers what the key needs are for a modern space compute solution, from our perspective – again considering autonomy as a foundation.