Program for Friday, September 23rd: Talk View

PROGRAM FOR FRIDAY, SEPTEMBER 23RD: TALK VIEW

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View: with abstracts session overview

8:30

9:00

9:30

10:00

10:30

11:00

11:30

12:00

12:30

13:00

13:30

14:00

14:30

15:00

15:30

16:00

16:30

17:00

17:30

18:00

18:30

19:00

19:30

20:00

20:30

21:00

21:30

22:00

22:30

23:00

23:30

08:30-10:15 MOLECULAR AND CELLULAR EFFECTS - MODELING

08:30-09:15

Describing and predicting radiation effects with parameter poor modeling

T. Friedrich

09:15-09:45

From mutation induction to secondary cancer risk predictions in particle therapy: modelling through systematic data collection and Microdosimetric Kinetic

Andrea Attili, Emanuele Scifoni, Francesco Tommasino

09:45-10:15

The “Stealth-Bomber” paradigm: a conceptualization of the tumor cell response to carbon ion

Wozny et.al

09:45-10:15

Tritiated micro-particles: modelling in-vitro exposure and biological effects

Mentana et.al

10:45-11:30 MOLECULAR AND CELLULAR EFFECTS - EXPERIMENTAL

10:45-11:30

Variability in cellular and individual response to radiation

Andrzej Wojcik

11:30-12:00

Carbon ion radiobiology: new insights in the molecular and cellular mechanisms of tumour control

Angelica Facoetti

12:00-12:30

Cellular effects of long-term radiation exposure on aquatic biota within the Chernobyl exclusion

Gudkov, Pomortseva, Shevtsova, Kaglyan, Kireev, Iavniuk, Drozdov

12:00-12:30

Effects of particle irradiation and oxidative stress response on survival and differentiation process of primary human stem

Mira Hammad, François Chevalier, Siamak Haghdoost

12:30-13:30

Exploring human plasma proteome in context of radiation biomarkers.

G. Rydlova, V. Vozandychova, H. Rehulkova, P. Rehulka, A. Myslivcova, A. Tichy

Role of protein glycosylation in radiation-induced immune cell recruitment

S. Ladaigue, V. Buard, G. Tarlet, A. François, V. Paget, F. Milliat, O. Guipaud

Role of KRAS mutation on NSCLC resistance to x-rays, protons and carbon ions

Juliette Montanari, Mathieu Césaire, Antoine Gilbert, Francois Chevalier

3D Tumor Models for Radiobiological Applications

F. Antonelli, N. Fiaschini, P. D'Atanasio, A. Zambotti, A. Rinaldi, M. Mancuso

Gold nanorods and radioisotopes: future diagnostic and therapeutic applications in nuclear medicine. Preliminary in vitro radiobiological

V. Dini, A. Giordano, E. Giuseppe, B. Ludoviac, B. Chiara, S. Teresa, V. Iole

Biomedical Applications of Radioactive ion Beams: First results of the BARB project at GSI

Daria Boscolo

Combination of nutrient deprivation and X-ray exposure induce synergic effect

Guardamagna, Maggi, Iaria, Previtali, Uggé, Lonati, Pessino, Mentana, Baiocco

The influence of the breast cancer cells sensitization by gold nanoparticles on the cell cycle distribution and the survivability rate in the case of Boron-Neutron Capture

Krakowiak et.al

Biological dosimetry for microbeam radiation therapy (MRT)

Schmid, Bicher, Nguyen, Dombrowsky, Treibel, Winter, Ahmed, Combs, Bartzsch

The effect of low- and high-dose rate brachytherapy on the innate and adaptive immune system of prostate cancer

K. Balázs, Z.S. Kocsis, Z. Jurányi, G. Sáfrány, K. Lumniczky

Fibroblast-based radiosensitivity assessment for primary immunodeficiency patients

E. Beyls, S. De Beul, F. Haerynck, V. Bordon, A. Ferster, A. Vral, A. Baeyens

Variation in intra- and intercellular response to radiation-induced DNA damage

Płódowska et.al

Margin reduction in particle therapy: potential benefits of using radioactive ion beams

Sokol et.al

Investigating transcriptional and translational responses to low-dose ionising radiation: towards an integrated low dose response

S. Eivers, A. Thomas-Joyeux, M. Gomot, V. Ménard, D. Klokov, G. Vares

The role of hypoxia and radiation in the stemness of murine osteosarcoma cells

M. Quartieri, A. Puspitasari, W. Tinganelli, O. Sokol, M. Durante

Short- and long-term effects on AHH-1 after low doses and dose rates of gamma radiation

Milagrosa Lopez-Riego, Pamela Akuwudike, Lovisa Lundholm, Andrzej Wojcik

Mechanistic insights from high resolution DNA damage analysis to understand mixed high and low LET radiation exposure and its therapeutic

Akuwudike et.al

Study of molecular pathways involved in second cancer induction after radiotherapy

Z. Kocibalova, P.K. Meher, P. Akuwudike, A. Wojcik, L. Lundholm

Migration behavior of U87 glioblastoma cells after irradiation with varying LET

Nicole Matejka, Sarah Rudigkeit, Matthias Sammer, Judith Reindl

Normal tissue effects in a murine model system from radiotherapy of the head and neck

Zlygosteva, Solgård Juvkam, Galtung, Søland, Malinen, Edin

Exosome secretion and cellular response of DU145 and PC3 after exposure to alpha radiation

Pszczółkowska et.al

CeCILE - intelligent detection, tracking and cell cycle evaluation of eukaryotic cells on phase-contrast live-cell

Sarah Rudigkeit, Hai Huang, Julian Reindl, Helmut Mayer, Judith Reindl

Improved cytotoxic effects of ionizing radiation in radioresistant tumor models using drug delivery

Roxana Cristina Popescu, Wolfgang Doerr, Diana Savu

The DNA damage response of peripheral blood lymphocytes exposed to X-rays with different beam qualities and

Sioen, D'Hondt, Bacher, Vanderstraeten, Krysko, Vral, Baeyens

Validation of FACS-based analysis of γH2AX foci formation and decay in human peripheral blood lymphocytes and U2OS

Płódowska, Węgierek-Ciuk, Lankoff, Wołowiec, Wójcik, Lisowska

Nadia Boroumand, Karine Elihn, Andrzej Wojcik, Lovisa Lundholm

Processed nanodiamonds as radiosensitizers for innovative applications in radiotherapy treatments

Varzi et.al

Analysis of γH2AX distribution at nanoscale on glioblastoma cell line

Molnár, Szabó, Polanek, Tőkés, Varga, Erdélyi, Hideghéty

Cytogenetic effects of low and high LET radiation on TK6 cells

Soukaïna Kawni, Siamak Haghdoost

A new biophysical model for treatment-plan biological optimization in hadron therapy

Carante et.al

Investigation of DNA damage repair dynamics of NBS1 foci in U2OS cells exposed to mixed beams

A. Tartas, L. Lundholm, H. Scherthan, A. Wojcik, B. Brzozowska

New insights into metal nanoparticle-mediated effects on chromatin organization at the micro- and nano-scale: Relevance for tumor cell

Falk et.al

Deciphering the role of the proteasome to explain the high biological efficacy of carbon ion

Wozny, Alphonse, Sebaï, Lole, Varoclier, Beuve, Ardail, Rodriguez-Lafrasse

Evaluation of innovative radiotherapy treatments in zebrafish

Gaia Pucci, Giusi Irma Forte, Vincenzo Cavalieri

Radioresistant primary breast cancer cells and hormone receptor status: looking for their main link.

Minafra, Bravatà, Cammarata, Calvaruso, Pucci, Russo, Forte

RNA-Sequencing Analysis of Glioblastoma xenograft mice models proton boron capture therapy treated: a portrait of its molecular

Bravatà, Cammarata, Forte, Minafra, Calvaruso, Vicario, Cuttone, Parenti, Russo

Tumor Microenvironment Alteration Induced By Radiotherapy Modifies Glioblastoma Cells Proliferation And Mitochondrial

Alberghina et.al

Metabolic regulation of the radiation response in cancer cells: opportunities for biological radiotherapy

J. Matschke, I. Götting, C. Waterkamp, D. Hoffmann, V. Jendrossek

Tumour cell damage after proton irradiation in the presence of boron compounds

Zahradnicek et.al

The use of the ATR inhibitor VE-821 as a potential tool for radiosensitivity estimation of cancer cell

S. Triantopoulou, A. Pantelias, A. Nikolakopoulou, G. Terzoudi

Radiolysis of concentrated myoglobin by accelerated ions

Raffy et.al

The lack of p21 sensitizes colon cancer cells to radiation-induced apoptosis.

C. Galeaz, G. Pellizzaro, G. Tonidandel, E. Verroi, M. Pancher, A. Bisio

Raman spectroscopy of plasma for prediction of radiotherapy response in patients with HPV-positive head and neck

Monaghan, D.Meade, Brennan, Mehanna, Fulton-Lieuw, Spruce, Dunn, Dalby, M. Lyng

Radiation therapy affects cellular internalization of hyaluronic acid coated-nanoparticles into breast

La Verde, Panzetta, La Commara, Netti, Ambrosino, Pugliese, Celentano

Nanodosimetry based radiobiological outcomes assessment

Monika Mietelska, Marcin Pietrzak, Beata Brzozowska, Zygmunt Szefliński

Mathematical modelling of low dose hyper-radiosensitivity and induced radioresistance

Szabolcs Polgár, Balázs Madas

Hyper-fractionation of 177Lu-octreotate increases the uptake in human GOT1 tumours in a mouse model

Mikael Elvborn, Emman Shubbar, Khalil Helou, Eva Forssell-Aronsson

Comparative studies of intestinal tumorigenesis in the ApcMin/+ mouse following acute or chronic gamma

Michele Ellender

Antiproliferative and radiosensitizing effects of the G4-ligand RHPS4 and its analogue 190 in breast cancer

Valenzuela et.al

Chemopotentiating effects of low-dose fractionated radiation in normal fibroblasts from patients with head and neck cancer treated with LDFR combined with induction

G. Winiarska, A. Gądek, W. Fidyk, T. Rutkowski, D. Słonina

Hadrontherapy and PARP inhibitor effects on Chondrosarcoma JJ012 Cancer Stem Cells

A. Gilbert, J. Montanari, K. Commenchail, S. Haghdoost, S. Valable, F. Chevalier

Activation of PPAR alpha by fenofibrate attenuates the effect of local heart high dose irradiation on the mouse cardiac

Omid Azimzadeh

Freezing and thawing cells to radio-sensitize tumour cells

Falkova, Falk, Kopecna, Pagacova, Golan, Bacikova, Kratochvilova, Hausmann

Dose-rate effect towards Radiolysis of Water and small Protein Biomolecules

Danvin et.al

Effects of 4He irradiation on cell cycle progression and induction of apoptosis in radioresistant cancer cell

Keta, Petković, Cammarata, Petringa, Cirrone, Cuttone, Petrović, Ristić-Fira

Direct and indirect effects of proton and carbon ion irradiations on breast adenocarcinoma cells

Petkovic, Keta, Cammarata, Petringa, Cirrone, Cuttone, Petrovic, Ristic Fira

Mechanism of chemopotentiating effects of low-dose fractionated radiation in head and neck cancer cell

D. Szeliga, Ł. Sroka, M. Głowala-Kosińska, T. Rutkowski, D. Słonina

The impact of chromatin architecture, its geometry and topology, on radiation induced damaging and following DNA repair

Hausmann et.al

A comparison of Geant4-DNA and TRAX-Chem toolkits to evaluate the effect of oxygen depletion in FLASH

Farrokhi, Shirani, Fattori, Jia, Ali Asgarian, Petringa, Cirrone

Breast Cancer Cell Microtubules: Target for Ionizing Radiation Effect

Simonetta Croci, Luca Bruno, Massimo Manghi, Valentina Caorsi

12:30-13:30 Council

13:30-15:15 TRANSLATIONAL AND CLINICAL RESEARCH - GENERAL

13:30-14:15

Targeting radiobiological hypoxia to improve radiotherapy response

Ester M. Hammond

14:15-14:45

Dosimetry for FLASH radiotherapy: challenges and recent developments

Francesco Romano

14:45-15:15

3D liver biological scaffolds: a promising approach for the evaluation of low and high LET radiation effects on radioresistant cell

Charalampopoulou et.al

14:45-15:15

Double fraction of synchrotron Microbeam Radiation Therapy improves local control and triggers regression of locoregional metastasis in murine

Trappetti et.al

15:45-17:30 TRANSLATIONAL AND CLINICAL RESEARCH - FLASH THERAPY

15:45-16:30

FLASH Radiotherapy: The start of a dose-rate revolution?

K. M. Prise

16:30-17:00

FLASH radiotherapy – towards clinical implementation

Crister Ceberg

17:00-17:30

FLASH with carbon ions: tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma

Tinganelli et.al

17:00-17:30

FLASH irradiation reduces radiation-induced skin and lung toxicity while being as efficient as conventional irradiation in antitumor

S. Paillas, A. Suarez-Bonnet, J.-L. Ruan, I. Tullis, K. Petersson

20:30-23:30 Social Dinner (Optional)

10:15-10:45 Coffee Break

12:30-13:30 Lunch Break

15:15-15:45 Coffee Break