Days: Tuesday, April 25th Wednesday, April 26th Thursday, April 27th Friday, April 28th Saturday, April 29th
View this program: with abstractssession overviewtalk overview
Diploma exams
ESHI Candidate preparation room
Inspectors' Workshop
Inspectors' dinner (by invitation only)
View this program: with abstractssession overviewtalk overview
Executive Committee meeting
EPT Committee meeting
Accreditation Committee meeting
Standards Committee meeting
IT & Bioinformatics Committee meeting
Open Meeting of the Population Genetics Working Group
Lunch Break
Education Committee meeting
SFHI Scientific Committee
Scientific Committee meeting
Young EFI Working Group
Timo Olieslagers (Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands, Netherlands)
OPENING CEREMONY
Ann-Margaret Little (Histocompatibility and Immunogenetics, Laboratory Medicine, Gartnavel General Hospital, Glasgow, UK, UK)
17:30 | Welcome Addresses |
18:00 | Julia Bodmer Award |
18:20 | HLA Award |
18:30 | Ceppellini Lecture |
View this program: with abstractssession overviewtalk overview
Cell Therapies & Hematopoietic Stem Cell Transplantation
Alexandre Walencik (Histocompatibility and Immunogenetics laboratory, EFS Centre-Pays de la Loire, Nantes, France, France)
Coffee Break
Innovation in Transplantation
Begoña Aran (Barcelona Stem Cell Bank, Regenerative Medicine Programme, Bellvitge Biomedical Research Institute (IDIBELL), Spain)
Paul-Olivier Rouzaire (Department of Histocompatibility & Immunogenetics, Clermont Auvergne University, France, France)
The use of AI to assist decision-making in transplantation
Gilles Blancho (Nantes Université, CHU Nantes, Inserm, CR2TI, UMR 1064, ITUN, France)
MHC Evolution, Population Genetics
Alicia Sanchez-Mazas (University of Geneva, Switzerland)
10:30 | From global population genetic profiles to detailed individual molecular variation in humans and chimpanzees: a new turn in our understanding of MHC diversity and evolution (abstract) PRESENTER: Alicia Sanchez-Mazas |
10:40 | CREATING FULLY REPRESENTATIVE MHC REFERENCE HAPLOTYPES (abstract) PRESENTER: Nicholas R. Pollock |
10:50 | MICA Copy Number Variations are the Result of Numerous Independent Non-Allelic Homologous Recombination Events (abstract) PRESENTER: Anja Klussmeier |
11:00 | High Frequency of MICA Gene Deletion Haplotypes in Several Non-European Populations (abstract) PRESENTER: Anja Klussmeier |
11:10 | Telomeres and ageing and their relation with HLA – results from the project “Immunogenetics of Ageing” within 18th IHIWS (abstract) PRESENTER: Katarzyna Bogunia-Kubik |
11:20 | Classical HLA alleles and long-range haplotypes are under rapid selection among admixed populations (abstract) PRESENTER: Yang Luo |
11:30 | Human Leukocyte Antigens (HLA) evolutionary divergence (HED) calculator (abstract) |
11:40 | A high-throughput approach to the MHC assembly challenge in disease association (abstract) PRESENTER: Kristen J. Wade |
New technologies & New Approaches in Immunogenetics
Florent Delbos (Histocompatibility and Immunogenetics laboratory, EFS Centre-Pays de la Loire, Nantes, France, France)
10:30 | The beneficial impact of HLA-E mismatching for patients receiving a less than 10/10 HLA matched hematopoietic cell transplant. (abstract) PRESENTER: Jonathan A.M. Lucas |
10:40 | Clinical relevance of cell-free DNA quantification and qualification during the first month after lung transplantation (abstract) PRESENTER: Pascal Pedini |
10:50 | Full-gene sequence characterisation of HLA-DMA, -DMB, -DOA, and -DOB in a panel of International HLA and Immunogenetics Workshop cell lines (abstract) PRESENTER: Matilda Tierney |
11:00 | Randomized trial to assess the clinical utility of renal allograft monitoring by urine CXCL10 chemokine (abstract) |
11:10 | Characterization of chimpanzee KIR haplotype organizations using Cas9 enrichment and Oxford Nanopore sequencing. (abstract) PRESENTER: Corrine Heijmans |
11:20 | TXMatching – a novel software for kidney paired donations (abstract) PRESENTER: Matěj Röder |
11:30 | HLA loss detection by NGS using STR markers within the MHC region on chromosome 6 (abstract) PRESENTER: Loes van de Pasch |
11:40 | Assessment of a Universal Blood Donor Genotyping Platform (abstract) PRESENTER: Colin Brown |
Coffee Break
EFI Executive Committee and Coordinators meeting
SHLARC Consortium meeting
Pierre-Antoine Gourraud (Nantes Université, CR2TI UMR1064, Nantes, France, France)
Luncheon Industry Symposium: CareDx
Luncheon Industry Symposium: Immucor
ETHIQ Diploma meeting
Coffee Break
Anthropology & Population Genetics: Immunogenetic diversity of the HLA system
Erick C. Castelli (Molecular Genetics and Bioinformatics Laboratory, Experimental Research Unity, School of Medicine, UNESP, Brazil)
Special Session 2: NAT "Control of the immune system in Transplantation"
Magali Giral (CHU Nantes, Université de Nantes, INSERM, CR2TI, UMR 1064, ITUN, Nantes, France, France)
14:30 | Regulatory T cells, translation to the clinic. |
15:00 | Regulatory B cells, where we are? |
15:30 | B cell functional subsets from autoimmunity to transplantation |
NK Cells & KIR
Danillo Augusto (University of North Carolina at Charlotte, USA, United States)
14:30 | Chromosomal rearrangements in the KIR gene cluster as evolutionary strategy to protect against evading pathogens (abstract) PRESENTER: Jesse Bruijnesteijn |
14:40 | Variegated expression of KIR regulated by conserved and diverged promoter regions in humans and macaques (abstract) PRESENTER: Marit van der Wiel |
14:50 | Polymorphism of HLA and KIR affects severity of COVID-19 by shaping innate and adaptive immunity to SARS-CoV-2 (abstract) PRESENTER: Ticiana Dj Farias |
15:00 | The role of natural killer cells in recurrent pregnancy loss: evaluation of natural killer cell education (abstract) PRESENTER: Amber Lombardi |
15:10 | KIR2DL2/C1: a potential predictive immunogenetic marker to COVID-19 severity in Spanish patients (abstract) PRESENTER: Jairo Eduardo Niño Ramirez |
15:20 | Nanopores may replace SMRT reads for dual redundant reference sequencing (DR2S): Characterization of more than 600 novel KIR alleles (abstract) PRESENTER: Kathrin Putke |
15:30 | Natural killer cell receptor variation is associated with more aggressive subtypes of breast cancer (abstract) PRESENTER: Danillo Augusto |
15:40 | HLA class I epitope and KIR diversities in multiple myeloma (abstract) PRESENTER: Nicky Beelen |
Immunogenetics in Organ Transplantation
Carole Guillonneau (Nantes Université, CR2TI UMR 1064, Nantes, France, France)
14:30 | Immunogenomic exploration in a large kidney transplantation genetic cohort reveals a kidney graft failure association with HLA-B*40:01 and KIRD2L2/HLA-C2 combination (abstract) PRESENTER: Nicolas Vince |
14:40 | In the era of precision medicine: lncRNAs as probable biomarkers to predict allograft rejection (abstract) PRESENTER: Uma Kanga |
14:50 | Gene expression profiles in 3 month biopsies associate with progression to kidney transplant rejection before detection of histological changes (abstract) PRESENTER: Mathijs Groeneweg |
15:00 | Precision medicine in liver transplant recipients: donor cell-free DNA as an early marker of post-transplant hepatic injury (abstract) PRESENTER: Monica Sorbini |
15:10 | Acute and chronic rejection monitoring of pediatric heart transplant recipients through a ddPCR assay based on HLA-DRB1 polymorphism (abstract) PRESENTER: Monica Sorbini |
15:20 | Genome-wide survival study identifies a novel association between donor genotype and antibody-mediated kidney graft rejection (abstract) PRESENTER: Vincent Mauduit |
15:30 | The number of donor HLA-derived T-cell epitopes available for indirect antigen presentation determines the risk for vascular rejection after kidney transplantation (abstract) PRESENTER: Emma Peereboom |
15:40 | Impact of HLA diversity on humoral response to SARS-Cov-2 and HBV vaccines in liver transplant recipients (abstract) PRESENTER: Jean-Luc Taupin |
Coffee Break
HLA Immunogenetics, Population genetics & Evolution
Lotte Wieten (MUMC+, Netherlands)
P1 – P21 - Autoimmunity, Infection, Reproduction & Cancer
P22 – P43 - Bioinformatics, Data Analysis in Immunogenetics
P44 – P67 - Hematopoietic Stem Cell Transplantation (HSCT)
P68 – P82 - Immunogenetics in Organ Transplantation
P83 – P109 - MHC Evolution, Population Genetics
P110 – P117 - NK cells & KIR
P118 – P130 - New Technologies & New Approaches in Immunogenetics
Ceppellini (by invitation only)
Speakers dinner (by invitation only)
View this program: with abstractssession overviewtalk overview
HLA in Solid Organ Transplantation
Gwendaline Guidicelli (Laboratoire d'Immunologie et Immunogénétique CHU de Bordeaux, Bordeaux, France, France)
08:30 | From HLA to MICA |
09:00 | HLA molecular matching to improve transplant outcomes. |
09:30 | Guiding pre-transplant desensitization and post-transplant DSA treatment. |
Coffee Break
KIR immunogenetics & HLA epitopes: Mapping approaches & prediction methods
Christelle Retière (Nantes Université, EFS, INSERM, CNRS, CRCI2NA, 44000, Nantes, France, France)
10:30 | KIR immunogenetics and NK cell diversity |
11:00 | HLA epitopes and matching from a big data perspective |
Society for Immune Polymorphism: Advances in Clinical Immunogenomics
Steven Mack (University of California, San Francisco, CA, United States., United States)
Paul Norman (University of Colorado, School of Medicine, Division of Biomedical Informatics and Personalized Medicine, Aurora, USA, United States)
10:30 | From Precision Microbial Genomics to Precision Medicine. |
11:00 | KIRs, T cell dynamics, control of chronic virus infection and autoimmunity |
11:30 | Immunogenetics of Hematopoietic Cell Transplantation |
Bioinformatics, data analysis in Immunogenetics
Raphael Carapito (University of Strasbourg, France)
10:30 | Unexposed individuals are fully equipped at the genetic level in terms of peptide coverage and T-cell repertoire against SARS-CoV-2: analysis in a cohort of healthy donors and alloHSCT recipients (abstract) PRESENTER: Stephane Buhler |
10:40 | A new hla-mapper algorithm for alignment optimization of HLA sequences from RNA-seq (abstract) PRESENTER: Erick Castelli |
10:50 | HLA-3Diff: redefining donor-recipients HLA matching based on three dimensional structure prediction (abstract) PRESENTER: Léo Boussamet |
11:00 | Human Leucocyte Antigen variation is associated with Cytomegalovirus seropositivity (abstract) PRESENTER: Juliano Boquett |
11:10 | A large, improved and ancestry-diverse reference panel to impute HLA classical and non-classical class I alleles (abstract) PRESENTER: Nayane S. B. Silva |
11:20 | Possible Biological Mechanisms Underlying the Association between COVID-19 Severity and HLA-C*04:01 (abstract) PRESENTER: Frieda Jordan |
11:30 | The expanded role of microRNAs in controlling the HLA class I phenotype: Relationship between the 3’ UTR and post-transcriptional Gene Regulation (abstract) PRESENTER: Panagiotis Mallis |
11:40 | Analysis of "Big Data" reveals a new MHC Class I sequence, HLA-OLI, and the location of HLA-Y (abstract) PRESENTER: Lindley Blair |
Immunotherapy, Gene Therapy, Cellular Therapy
Katia Gagne (Laboratoire de Recherche, Equipe 12 CRCI2NA, INSERM UMR1307, CNRS UMR 6075 EFS Centre-Pays de la Loire, France)
10:30 | Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells (abstract) PRESENTER: Paul Norman |
10:40 | Memory CD4+ T cells efficiently recognize divergent HLA-DP immunopeptidomes relevant in allogeneic hematopoietic cell transplantation (abstract) PRESENTER: Kulvara Kittissares |
10:50 | Discovery of the human cytomegalovirus-specific peptide repertoire naturally processed and presented by infected human antigen presenting cells (abstract) PRESENTER: Maria Michela Santamorena |
11:00 | Exploring the cryptic HLA-DP immunopeptidome for new targets of T cell immunotherapy in acute myeloid leukemia (abstract) PRESENTER: Pietro Crivello |
11:10 | Generation and Characterization of third party donor derived AdV, CMV and EBV multivirus specific T cells for therapeutic intervention in patients undergoing Hematopoietic Stem Cell Transplantation (abstract) PRESENTER: Meenakshi Singh |
11:20 | Optimal population coverage for cellular therapies (abstract) PRESENTER: Yoram Louzoun |
11:30 | THE STIMULATION OF MEMORY B CELLS FOR THE IDENTIFICATION OF UNACCEPTABLE ANTIGENS IN SOLID ORGAN TRANSPLANTATION (abstract) PRESENTER: Linh Truong |
11:40 | New regulatory dimensions for transplantation, genetics and stem cell research in the French bioethics law. Consequences for European collaborations. (abstract) PRESENTER: Anne Cambon-Thomsen |
Coffee Break
SIP Board meeting
Steven Mack (University of California, San Francisco, CA, United States., United States)
Luncheon Industry symposium: GenDx
Luncheon Industry symposium: One Lambda Inc. A Thermo Fisher Scientific Brand
EBTI GA
Bioinformatics for Research Application: Haplotype and Population Structure Inference using AI
Jean-Baptiste Woillard (Pharmacology, Toxicology Department, CHU Limoges/ INSERM U1248, University of Limoges, Limoges, France, France)
Mathijs Groeneweg (Maastricht University Medical Centre, Netherlands)
14:30 | Pinpointing HLA selection signal in admixed populations |
15:00 | Application of machine learning to prediction of immunosuppressant exposure, the example of tacrolimus |
Meet the expert & Young EFI
Arianne Brandsma (Immunogenetics department, Sanquin Diagnostiek B.V, Netherlands, Netherlands)
Steven Marsh (Anthony Nolan Research Institute, Cancer Institute, University College London, London, UK, UK)
Timo Olieslagers (Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands, Netherlands)
Katharina Fleischhauer (University Hospital Essen, Germany)
Hematopoietic Stem Cell Transplantation (HSCT)
Antonij Slavčev (Institute for Clinical and Experimental Medicine, Prague, Czechia)
14:30 | HLA-DP permissive mismatch subsets confer reduced aGvHD risks and improved disease control after hematopoietic cell transplantation for acute leukemia and myelodysplastic syndromes (abstract) PRESENTER: Esteban Arrieta Bolaños |
14:40 | T cells can be activated by epitopes presented on HLA-C*04:09N (abstract) PRESENTER: Carlotta Welters |
14:50 | Longitudinal tracking of T – cell receptor repertoire reconstitution after allogeneic hematopoietic stem cell transplantation (abstract) PRESENTER: Antonia Schäfer |
15:00 | Associations between HLA Evolutionary Divergence and clinical outcome of matched related or unrelated stem cell transplantation: a study from the EBMT Cellular Therapy and Immunobiology Working Party (abstract) PRESENTER: Pietro Crivello |
15:10 | The role of Recipient Specific Antibodies (RSA) in transplant outcome. Analysis of a group of family donors selected for patients undergoing haploidentical transplantation. (abstract) PRESENTER: Annamaria Pasi |
15:20 | HLA evolutionary divergence (HED) influences the outcome of haploidentical hematopoietic stem cell transplantation in adult patients with hematological malignancies. (abstract) PRESENTER: Debora Jorge Cordeiro |
15:30 | Combined imputation of HLA genotype and race leads to better donor-recipient matching (abstract) PRESENTER: Yoram Louzoun |
15:40 | Genetic variation in HLA genes: impact on transplant compatibility in a Brazilian admixed population (abstract) PRESENTER: Heloísa S Andrade |
Autoimmunity, Infection, Reproduction & Cancer
Régis Josien (Nantes Université, CHU Nantes, INSERM, CR2TI UMR 1064, Nantes, France, France)
14:30 | A Protective HLA Extended Haplotype Outweighs the Major COVID-19 Risk Factor Inherited from Neanderthals in the Sardinian Population. (abstract) PRESENTER: Stefano Mocci |
14:40 | HLA-A*03:01 significantly predicts strong humoral response at six months after mRNA vaccination: results from the observational prospective cohort study RENAISSANCE (abstract) PRESENTER: Roberto Crocchiolo |
14:50 | NEGR1 genetic variants and risk for virological failure in the HIV-positive Botswanian population (abstract) PRESENTER: Martin Morin |
15:00 | Copy number variation of the C4L gene isoform is associated with risk for multiple sclerosis” (abstract) PRESENTER: Jacqueline Williams |
15:10 | To study the HLA-E expression in HPV infected Cervical Carcinoma (abstract) PRESENTER: Ritu Aggarwal |
15:20 | HLA binding-groove motifs are associated with myocarditis induction after Pfizer-BioNTech BNT162b2 vaccination (abstract) PRESENTER: Gil Benedek |
15:30 | HLA-Bw4 is Associated with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) (abstract) PRESENTER: Kerry Kizer |
15:40 | Fight against COVID-19: functional and structural study of the T cell response (abstract) |
Coffee Break
AI & Big data transforming medical research
James Robinson (Anthony Nolan Research Institute, UK)
EFI GENERAL ASSEMBLY
View this program: with abstractssession overviewtalk overview
Best Abstract Session
Ann-Margaret Little (Histocompatibility and Immunogenetics, Laboratory Medicine, Gartnavel General Hospital, Glasgow, UK, UK)
08:30 | Forward or reversed binding of peptides within the HLA-DP peptidome is mainly determined by the HLA-DPB1 allele but with a key role for the HLA-DPA1 chain. (abstract) PRESENTER: Michel Kester |
08:40 | Single cell transcriptomics to identify leukemia-intrinsic and -extrinsic bone marrow correlates of immune escape and post-transplantation relapse (abstract) PRESENTER: Marco Punta |
08:50 | Highly specific Latent Membrane Protein 2A-targeting T-Cell Receptor-engineered T cells with inducible Interleukin-18 expression as promising tool to treat Epstein-Barr Virus-associated malignancies (abstract) PRESENTER: Philip Mausberg |
09:00 | Proteome analysis of drug susceptible HLA-B*57:01+ cells reveals the pivotal mechanisms of HLA-mediated Carbamazepine hypersensitivity (abstract) PRESENTER: Funmilola Josephine Haukamp |
09:10 | The evolution of MHC class I loss in a newly emerged transmissible cancer in Tasmanian devils (abstract) PRESENTER: Kathryn Hussey |
09:20 | Bw4 ligand and direct T-cell receptor binding induced selection on HLA A and B alleles (abstract) PRESENTER: Yoram Louzoun |
09:30 | The 18th International HLA and Immunogenetics Workshop (IHIWS) HLA immunogenic epitope project (abstract) PRESENTER: Cynthia Kramer |
09:40 | Spatial composition of decidual immune cells in oocyte donation pregnancies in relation to fetal-maternal HLA incompatibility (abstract) PRESENTER: Xuezi Tian |
Coffee Break
Autoimmune diseases & Infections
John Trowsdale (Cambridge University, UK)
Closing Ceremony
Ann-Margaret Little (Histocompatibility and Immunogenetics, Laboratory Medicine, Gartnavel General Hospital, Glasgow, UK, UK)